Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells

Detalhes bibliográficos
Autor(a) principal: Furlanetto, Tania Weber
Data de Publicação: 2001
Outros Autores: Nunes Junior, R. B., Sopelsa, Andreia Maria Ida, Maciel, R.M.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRGS
Texto Completo: http://hdl.handle.net/10183/21115
Resumo: Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
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spelling Furlanetto, Tania WeberNunes Junior, R. B.Sopelsa, Andreia Maria IdaMaciel, R.M.B.2010-04-24T04:15:22Z20010100-879Xhttp://hdl.handle.net/10183/21115000301594Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263EstradiolIodetosModelos animaisIodide uptakeEstradiolThyroidFollicular cellsEstradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cellsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000301594.pdf000301594.pdfTexto completo (inglês)application/pdf140162http://www.lume.ufrgs.br/bitstream/10183/21115/1/000301594.pdf8b210a1f0c6b03f97397b09c3b1f250cMD51TEXT000301594.pdf.txt000301594.pdf.txtExtracted Texttext/plain18225http://www.lume.ufrgs.br/bitstream/10183/21115/2/000301594.pdf.txt18997b287707cd40cd13671ba615efbfMD52THUMBNAIL000301594.pdf.jpg000301594.pdf.jpgGenerated Thumbnailimage/jpeg1644http://www.lume.ufrgs.br/bitstream/10183/21115/3/000301594.pdf.jpgf0b95cc21aed69ef04c9a1489ea6e22aMD5310183/211152023-10-27 03:27:54.841909oai:www.lume.ufrgs.br:10183/21115Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-27T06:27:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false
dc.title.pt_BR.fl_str_mv Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
spellingShingle Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Furlanetto, Tania Weber
Estradiol
Iodetos
Modelos animais
Iodide uptake
Estradiol
Thyroid
Follicular cells
title_short Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_full Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_fullStr Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_full_unstemmed Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
title_sort Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
author Furlanetto, Tania Weber
author_facet Furlanetto, Tania Weber
Nunes Junior, R. B.
Sopelsa, Andreia Maria Ida
Maciel, R.M.B.
author_role author
author2 Nunes Junior, R. B.
Sopelsa, Andreia Maria Ida
Maciel, R.M.B.
author2_role author
author
author
dc.contributor.author.fl_str_mv Furlanetto, Tania Weber
Nunes Junior, R. B.
Sopelsa, Andreia Maria Ida
Maciel, R.M.B.
dc.subject.por.fl_str_mv Estradiol
Iodetos
Modelos animais
topic Estradiol
Iodetos
Modelos animais
Iodide uptake
Estradiol
Thyroid
Follicular cells
dc.subject.eng.fl_str_mv Iodide uptake
Estradiol
Thyroid
Follicular cells
description Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.
publishDate 2001
dc.date.issued.fl_str_mv 2001
dc.date.accessioned.fl_str_mv 2010-04-24T04:15:22Z
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dc.language.iso.fl_str_mv eng
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dc.relation.ispartof.pt_BR.fl_str_mv Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263
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