Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells
Autor(a) principal: | |
---|---|
Data de Publicação: | 2001 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/21115 |
Resumo: | Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis. |
id |
UFRGS-2_eed8c369c99784f4d488219e65b11011 |
---|---|
oai_identifier_str |
oai:www.lume.ufrgs.br:10183/21115 |
network_acronym_str |
UFRGS-2 |
network_name_str |
Repositório Institucional da UFRGS |
repository_id_str |
|
spelling |
Furlanetto, Tania WeberNunes Junior, R. B.Sopelsa, Andreia Maria IdaMaciel, R.M.B.2010-04-24T04:15:22Z20010100-879Xhttp://hdl.handle.net/10183/21115000301594Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis.application/pdfengBrazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263EstradiolIodetosModelos animaisIodide uptakeEstradiolThyroidFollicular cellsEstradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cellsinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/otherinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000301594.pdf000301594.pdfTexto completo (inglês)application/pdf140162http://www.lume.ufrgs.br/bitstream/10183/21115/1/000301594.pdf8b210a1f0c6b03f97397b09c3b1f250cMD51TEXT000301594.pdf.txt000301594.pdf.txtExtracted Texttext/plain18225http://www.lume.ufrgs.br/bitstream/10183/21115/2/000301594.pdf.txt18997b287707cd40cd13671ba615efbfMD52THUMBNAIL000301594.pdf.jpg000301594.pdf.jpgGenerated Thumbnailimage/jpeg1644http://www.lume.ufrgs.br/bitstream/10183/21115/3/000301594.pdf.jpgf0b95cc21aed69ef04c9a1489ea6e22aMD5310183/211152023-10-27 03:27:54.841909oai:www.lume.ufrgs.br:10183/21115Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2023-10-27T06:27:54Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
spellingShingle |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells Furlanetto, Tania Weber Estradiol Iodetos Modelos animais Iodide uptake Estradiol Thyroid Follicular cells |
title_short |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_full |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_fullStr |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_full_unstemmed |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
title_sort |
Estradiol decreases iodide uptake by rat thyroid follicular FRTL-5 cells |
author |
Furlanetto, Tania Weber |
author_facet |
Furlanetto, Tania Weber Nunes Junior, R. B. Sopelsa, Andreia Maria Ida Maciel, R.M.B. |
author_role |
author |
author2 |
Nunes Junior, R. B. Sopelsa, Andreia Maria Ida Maciel, R.M.B. |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Furlanetto, Tania Weber Nunes Junior, R. B. Sopelsa, Andreia Maria Ida Maciel, R.M.B. |
dc.subject.por.fl_str_mv |
Estradiol Iodetos Modelos animais |
topic |
Estradiol Iodetos Modelos animais Iodide uptake Estradiol Thyroid Follicular cells |
dc.subject.eng.fl_str_mv |
Iodide uptake Estradiol Thyroid Follicular cells |
description |
Estradiol has well-known indirect effects on the thyroid. A direct effect of estradiol on thyroid follicular cells, increasing cell growth and reducing the expression of the sodium-iodide symporter gene, has been recently reported. The aim of the present investigation was to study the effect of estradiol on iodide uptake by thyroid follicular cells, using FRTL-5 cells as a model. Estradiol decreased basal iodide uptake by FRTL-5 cells from control levels of 2.490 ± 0.370 to 2.085 ± 0.364 pmol I-/µg DNA at 1 ng/ml (P<0.02), to 1.970 ± 0.302 pmol I-/µg DNA at 10 ng/ml (P<0.003), and to 2.038 ± 0.389 pmol I-/µg DNA at 100 ng/ml (P<0.02). In addition, 4 ng/ml estradiol decreased iodide uptake induced by 0.02 mIU/ml thyrotropin from 8.678 ± 0.408 to 7.312 ± 0.506 pmol I-/µg DNA (P<0.02). A decrease in iodide uptake by thyroid cells caused by estradiol has not been described previously and may have a role in goiter pathogenesis. |
publishDate |
2001 |
dc.date.issued.fl_str_mv |
2001 |
dc.date.accessioned.fl_str_mv |
2010-04-24T04:15:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/other |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://hdl.handle.net/10183/21115 |
dc.identifier.issn.pt_BR.fl_str_mv |
0100-879X |
dc.identifier.nrb.pt_BR.fl_str_mv |
000301594 |
identifier_str_mv |
0100-879X 000301594 |
url |
http://hdl.handle.net/10183/21115 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.pt_BR.fl_str_mv |
Brazilian journal of medical and biological research. Ribeirão Preto, SP. Vol. 34, no. 2 (Feb. 2001), p. 259-263 |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
application/pdf |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRGS instname:Universidade Federal do Rio Grande do Sul (UFRGS) instacron:UFRGS |
instname_str |
Universidade Federal do Rio Grande do Sul (UFRGS) |
instacron_str |
UFRGS |
institution |
UFRGS |
reponame_str |
Repositório Institucional da UFRGS |
collection |
Repositório Institucional da UFRGS |
bitstream.url.fl_str_mv |
http://www.lume.ufrgs.br/bitstream/10183/21115/1/000301594.pdf http://www.lume.ufrgs.br/bitstream/10183/21115/2/000301594.pdf.txt http://www.lume.ufrgs.br/bitstream/10183/21115/3/000301594.pdf.jpg |
bitstream.checksum.fl_str_mv |
8b210a1f0c6b03f97397b09c3b1f250c 18997b287707cd40cd13671ba615efbf f0b95cc21aed69ef04c9a1489ea6e22a |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS) |
repository.mail.fl_str_mv |
|
_version_ |
1801224710424363008 |