ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRGS |
Texto Completo: | http://hdl.handle.net/10183/129821 |
Resumo: | Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a higher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20–2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes. |
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Borghese, BrunoChartier, MélanieSouza, Carlos Augusto Bastos deSantulli, PietroPillet, Marie-Christine LafayZiegler, Dominique deChapron, Charles2015-11-18T02:38:06Z20142314-6141http://hdl.handle.net/10183/129821000977244Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a higher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20–2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes.application/pdfengBioMed Research International. New York, NY. Vol. 2014 (2014), ID 618964, [6] p.EndometrioseSistema do grupo sanguíneo ABOSistema do grupo sanguíneo Rh-HrPredisposição genética para doençaABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic areaEstrangeiroinfo:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UFRGSinstname:Universidade Federal do Rio Grande do Sul (UFRGS)instacron:UFRGSORIGINAL000977244.pdf000977244.pdfTexto completo (inglês)application/pdf511117http://www.lume.ufrgs.br/bitstream/10183/129821/1/000977244.pdf64cad419c0b4a8540732dc0f434cd6a1MD51TEXT000977244.pdf.txt000977244.pdf.txtExtracted Texttext/plain29031http://www.lume.ufrgs.br/bitstream/10183/129821/2/000977244.pdf.txtb94fcbf8437df24cb4d6caec9443b020MD52THUMBNAIL000977244.pdf.jpg000977244.pdf.jpgGenerated Thumbnailimage/jpeg1678http://www.lume.ufrgs.br/bitstream/10183/129821/3/000977244.pdf.jpgb0d5932c6592df70a36745f507e9c654MD5310183/1298212018-10-25 09:16:34.77oai:www.lume.ufrgs.br:10183/129821Repositório de PublicaçõesPUBhttps://lume.ufrgs.br/oai/requestopendoar:2018-10-25T12:16:34Repositório Institucional da UFRGS - Universidade Federal do Rio Grande do Sul (UFRGS)false |
dc.title.pt_BR.fl_str_mv |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
title |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
spellingShingle |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area Borghese, Bruno Endometriose Sistema do grupo sanguíneo ABO Sistema do grupo sanguíneo Rh-Hr Predisposição genética para doença |
title_short |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
title_full |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
title_fullStr |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
title_full_unstemmed |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
title_sort |
ABO and rhesus blood groups and risk of endometriosis in a French caucasian population of 633 patients living in the same geographic area |
author |
Borghese, Bruno |
author_facet |
Borghese, Bruno Chartier, Mélanie Souza, Carlos Augusto Bastos de Santulli, Pietro Pillet, Marie-Christine Lafay Ziegler, Dominique de Chapron, Charles |
author_role |
author |
author2 |
Chartier, Mélanie Souza, Carlos Augusto Bastos de Santulli, Pietro Pillet, Marie-Christine Lafay Ziegler, Dominique de Chapron, Charles |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Borghese, Bruno Chartier, Mélanie Souza, Carlos Augusto Bastos de Santulli, Pietro Pillet, Marie-Christine Lafay Ziegler, Dominique de Chapron, Charles |
dc.subject.por.fl_str_mv |
Endometriose Sistema do grupo sanguíneo ABO Sistema do grupo sanguíneo Rh-Hr Predisposição genética para doença |
topic |
Endometriose Sistema do grupo sanguíneo ABO Sistema do grupo sanguíneo Rh-Hr Predisposição genética para doença |
description |
Objectives.The identification of epidemiological factors increasing the risk of endometriosis could shorten the time to diagnosis. Specific blood groups may be more common in patients with endometriosis. Study Design. We designed a cross-sectional study of 633 Caucasian women living in the same geographic area. Study group included 311 patients with histologically proven endometriosis. Control group included 322 patients without endometriosis as checked during surgery. Frequencies of ABO and Rhesus groups in the study and control groups were compared using univariate and multivariate analyses. Results. We observed a higher proportion of Rh-negativewomen in the study group, as compared to healthy controls.Multivariate analysis showed that Rhnegative women are twice as likely to develop endometriosis (aOR = 1.90; 95% CI: 1.20–2.90). There was no significant difference in ABO group distribution between patients and controls. There was no difference when taking into account either the clinical forms (superficial endometriosis, endometrioma, and deep infiltration endometriosis) or the rAFS stages. Conclusion. Rh-negative women are twice as likely to develop endometriosis. Chromosome 1p, which contains the genes coding for the Rhesus, could also harbor endometriosis susceptibility genes. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014 |
dc.date.accessioned.fl_str_mv |
2015-11-18T02:38:06Z |
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eng |
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BioMed Research International. New York, NY. Vol. 2014 (2014), ID 618964, [6] p. |
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openAccess |
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