No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population

Detalhes bibliográficos
Autor(a) principal: Dourado Junior, Mário Emílio Teixeira
Data de Publicação: 2016
Outros Autores: Ferreira, Leonardo Capistrano, Freire Neto, Francisco Paulo, Jeronimo, Selma M.B.
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/54253
https://doi.org/10.1016/j.jneuroim.2016.07.020
Resumo: The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.
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spelling Dourado Junior, Mário Emílio TeixeiraFerreira, Leonardo CapistranoFreire Neto, Francisco PauloJeronimo, Selma M.B.https://orcid.org/0000-0002-9462-22942023-07-28T12:32:44Z2023-07-28T12:32:44Z2016DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54253https://doi.org/10.1016/j.jneuroim.2016.07.020Elsevierguillain-barré syndromepolymorphismgeneticsNo association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccess123456789/542532023-07-28 09:33:14.778oai:https://repositorio.ufrn.br:123456789/54253Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-28T12:33:14Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
title No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
spellingShingle No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
Dourado Junior, Mário Emílio Teixeira
guillain-barré syndrome
polymorphism
genetics
title_short No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
title_full No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
title_fullStr No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
title_full_unstemmed No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
title_sort No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
author Dourado Junior, Mário Emílio Teixeira
author_facet Dourado Junior, Mário Emílio Teixeira
Ferreira, Leonardo Capistrano
Freire Neto, Francisco Paulo
Jeronimo, Selma M.B.
author_role author
author2 Ferreira, Leonardo Capistrano
Freire Neto, Francisco Paulo
Jeronimo, Selma M.B.
author2_role author
author
author
dc.contributor.authorID.pt_BR.fl_str_mv https://orcid.org/0000-0002-9462-2294
dc.contributor.author.fl_str_mv Dourado Junior, Mário Emílio Teixeira
Ferreira, Leonardo Capistrano
Freire Neto, Francisco Paulo
Jeronimo, Selma M.B.
dc.subject.por.fl_str_mv guillain-barré syndrome
polymorphism
genetics
topic guillain-barré syndrome
polymorphism
genetics
description The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.
publishDate 2016
dc.date.issued.fl_str_mv 2016
dc.date.accessioned.fl_str_mv 2023-07-28T12:32:44Z
dc.date.available.fl_str_mv 2023-07-28T12:32:44Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/54253
dc.identifier.doi.none.fl_str_mv https://doi.org/10.1016/j.jneuroim.2016.07.020
identifier_str_mv DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023.
url https://repositorio.ufrn.br/handle/123456789/54253
https://doi.org/10.1016/j.jneuroim.2016.07.020
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
instname:Universidade Federal do Rio Grande do Norte (UFRN)
instacron:UFRN
instname_str Universidade Federal do Rio Grande do Norte (UFRN)
instacron_str UFRN
institution UFRN
reponame_str Repositório Institucional da UFRN
collection Repositório Institucional da UFRN
repository.name.fl_str_mv Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)
repository.mail.fl_str_mv
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