No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population
Autor(a) principal: | |
---|---|
Data de Publicação: | 2016 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54253 https://doi.org/10.1016/j.jneuroim.2016.07.020 |
Resumo: | The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population. |
id |
UFRN_03df00b45431bd6f218bd223beba5ff4 |
---|---|
oai_identifier_str |
oai:https://repositorio.ufrn.br:123456789/54253 |
network_acronym_str |
UFRN |
network_name_str |
Repositório Institucional da UFRN |
repository_id_str |
|
spelling |
Dourado Junior, Mário Emílio TeixeiraFerreira, Leonardo CapistranoFreire Neto, Francisco PauloJeronimo, Selma M.B.https://orcid.org/0000-0002-9462-22942023-07-28T12:32:44Z2023-07-28T12:32:44Z2016DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54253https://doi.org/10.1016/j.jneuroim.2016.07.020Elsevierguillain-barré syndromepolymorphismgeneticsNo association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian populationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccess123456789/542532023-07-28 09:33:14.778oai:https://repositorio.ufrn.br:123456789/54253Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-28T12:33:14Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
title |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
spellingShingle |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population Dourado Junior, Mário Emílio Teixeira guillain-barré syndrome polymorphism genetics |
title_short |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
title_full |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
title_fullStr |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
title_full_unstemmed |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
title_sort |
No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population |
author |
Dourado Junior, Mário Emílio Teixeira |
author_facet |
Dourado Junior, Mário Emílio Teixeira Ferreira, Leonardo Capistrano Freire Neto, Francisco Paulo Jeronimo, Selma M.B. |
author_role |
author |
author2 |
Ferreira, Leonardo Capistrano Freire Neto, Francisco Paulo Jeronimo, Selma M.B. |
author2_role |
author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9462-2294 |
dc.contributor.author.fl_str_mv |
Dourado Junior, Mário Emílio Teixeira Ferreira, Leonardo Capistrano Freire Neto, Francisco Paulo Jeronimo, Selma M.B. |
dc.subject.por.fl_str_mv |
guillain-barré syndrome polymorphism genetics |
topic |
guillain-barré syndrome polymorphism genetics |
description |
The pathogenesis of Guillain-Barré Syndrome (GBS) is not entirely understood, but includes infection-induced aberrant immune responses. Genetic polymorphisms in Fc gamma receptor genes (FCGR) have been associated with GBS. We assessed whether polymorphisms rs1801274 in FCGR2A and rs396991 in FCGR3A were associated with GBS in a Brazilian population. We genotyped 141 GBS cases and 364 healthy controls from Brazil for both polymorphisms. The FCGR genotypes and alleles frequencies did not differ significantly between GBS and controls. In addition, there was no genetic association with either severity or clinical outcomes. We conclude that these FCGR polymorphisms are not associated with susceptibility to Guillain-Barré Syndrome in this Brazilian population. |
publishDate |
2016 |
dc.date.issued.fl_str_mv |
2016 |
dc.date.accessioned.fl_str_mv |
2023-07-28T12:32:44Z |
dc.date.available.fl_str_mv |
2023-07-28T12:32:44Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54253 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1016/j.jneuroim.2016.07.020 |
identifier_str_mv |
DOURADO JUNIOR, Mario Emilio Teixeira; FERREIRA, Leonardo Capistrano; FREIRE NETO, Francisco Paulo; JERONIMO, Selma M.B.. No association between FCGR2A and FCGR3A polymorphisms in Guillain-Barré Syndrome in a Brazilian population. Journal Of Neuroimmunology, [S.L.], v. 298, p. 160-164, set. 2016. Elsevier BV. http://dx.doi.org/10.1016/j.jneuroim.2016.07.020. Disponível em: https://www.sciencedirect.com/science/article/pii/S016557281630176X?via%3Dihub. Acesso em: 21 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54253 https://doi.org/10.1016/j.jneuroim.2016.07.020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
instname_str |
Universidade Federal do Rio Grande do Norte (UFRN) |
instacron_str |
UFRN |
institution |
UFRN |
reponame_str |
Repositório Institucional da UFRN |
collection |
Repositório Institucional da UFRN |
repository.name.fl_str_mv |
Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN) |
repository.mail.fl_str_mv |
|
_version_ |
1802117785622413312 |