Antecedent infections in Guillain-Barré syndrome in endemic areas of arbovirus transmission: a multinational case-control study

• Autor(a) principal: Dourado Junior, Mário Emílio Teixeira
• Data de Publicação: 2021
• Outros Autores: Leonhard, Sonja E., Tan, heng Yin, Leonhard, Sonja E, Tan, Cheng Yin, Eijk, Annemiek A., Reisin, Ricardo R., Franken, Suzanne C., Huizinga, Ruth, Arends, Samuel, Batstra, Manou R., Jeronimo, Selma M. Bezerra, Drenthen, Judith
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/handle/123456789/54205; http://dx.doi.org/10.1111/jns.12469
• topic: anti-ganglioside antibodies; anti-glycolipid antibodies; chikungunya virus; dengue virus; guillain-barré syndrome; zika virus

Half of the world's population is at risk of arthropod-borne virus (arbovirus) infec-tions. Several arbovirus infections have been associated with Guillain-Barré syn-drome (GBS). We investigated whether arboviruses are driving GBS beyond epidemicphases of transmission and studied the antibody response to glycolipids. The proto-col of the International Guillain-Barré syndrome Outcome Study (IGOS), an observa-tional prospective cohort study, was adapted to a case-control design. Serumsamples were tested for a recent infection with Zika virus (ZIKV), dengue virus(DENV), chikungunya (CHIKV) virus, hepatitis E virus, Epstein-Barr virus (EBV), cyto-megalovirus (CMV),Campylobacter jejuni, andMycoplasma pneumoniae, and for anti-bodies to glycolipids. Forty-nine patients were included from Brazil (63%), Argentina(14%), and Malaysia (22%). Evidence of a recent infection was found in 27/49 (55%)patients:C jejuni(n=15, 31%),M pneumoniae(n=5, 10%), CHIKV (n=2, 4%), EBV(n=1, 2%),C jejuniandM pneumoniae(n=2, 4%), CMV and DENV (n=1, 2%), andC jejuniand DENV (n=1, 2%). In 22 patients, 35 paired controls were collected.Odds ratio for recent infections did not significantly differ between cases and con-trols. No typical anti-ganglioside antibody binding was associated with recent arbovi-rus infection. We conclude that arbovirus infections occur in GBS patients outside ofepidemic viral transmission, although not significantly more than in controls. Broadinfection and anti-ganglioside antibody serology are important to establish the mostlikely pathogenic trigger in GBS patients. Larger studies are necessary to determinethe association between arboviruses and GBS.