12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach

Detalhes bibliográficos
Autor(a) principal: Farias, Pablo Felipe Ferreira
Data de Publicação: 2020
Tipo de documento: Trabalho de conclusão de curso
Idioma: por
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/35820
Resumo: Capes e CNPq
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spelling Farias, Pablo Felipe FerreiraDouglas Dourado OliveiraEgito, Eryvaldo Sócrates Tabosa doMarcelino, Henrique RodriguesAzevedo, Eduardo Pereira deEgito, Eryvaldo Sócrates Tabosa do2020-07-24T13:53:03Z2021-09-20T17:52:26Z2020-07-24T13:53:03Z2020-07-1020160127641FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/handle/123456789/35820Capes e CNPq12-Hydroxystearic acid (12-HSA)-based organogels are self-assembled systems that allow trapping organic solvents, such as natural oils. Therefore, they are excellent choice in the pharmaceutical field to load lipophilic molecules. Based on this, the aim of this study was to obtain 12-HSA-based organogels loading curcumin at different concentrations of the organogelator (2, 5 and 10 % w / w) in Miglyol ® 812 N, a medium chain triglyceride widely used in the pharmaceutical field. The physicochemical, thermal and mechanical properties of the produced organogels were elucidated by techniques, such as FTIR, XRD, visual sol-gel temperature transition and texture analysis. The characterization assays revealed that the organogels have an amorphous due to the oil composition. It also demonstrated that the model molecule, curcumin, was solubilized in the oil, which was entrapped by the crystalline matrix. Additionally, the thermal profile of the systems at different 12-HSA concentrations demonstrated the thermoreversible property of the gels and the addition of curcumin did not interfere in this property, which in general it may suggest a thermal stability profile that allows its storage at high temperatures. The mechanical profile results pointed out the possibility of use in several administration routes depending on the gelling agent concentration. Thereafter, it was possible to verify that the addition of the drug did not change the physicochemical and mechanical properties of the 12-HSA organogels, suggesting that this system is able to trap other drug other drug candidates. In view of these results, it is noteworthy the versatility of such organogels based on their amorphous nature and variable hardness, which could preclude their use in different field applications. The system could also become a viable delivery system to a wide range of drugs once they do not interfere on their characteristics. Therefore, for its future use, additional release, safety and biological activity studies need to be carried out.Universidade Federal do Rio Grande do NorteUFRNBrasilFármaciaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccess12-HSAcurcuminself-assembly12-Hydroxystearic acid12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisporreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINAL12Hydroxystearicacidbasedorganogel_Farias_2020Texto Completoapplication/pdf828611https://repositorio.ufrn.br/bitstream/123456789/35820/1/12Hydroxystearicacidbasedorganogel_Farias_2020bca836d438e87790e126ea0e880e78a8MD51CC-LICENSElicense_rdfapplication/pdf811https://repositorio.ufrn.br/bitstream/123456789/35820/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txttext/plain714https://repositorio.ufrn.br/bitstream/123456789/35820/3/license.txt7278bab9c5c886812fa7d225dc807888MD53TEXT12Hydroxystearicacidbasedorganogel_Farias_2020.txtExtracted texttext/plain60524https://repositorio.ufrn.br/bitstream/123456789/35820/4/12Hydroxystearicacidbasedorganogel_Farias_2020.txt76783bbc34e90a7eecb6380755449fcbMD54123456789/358202023-08-14 09:57:17.942oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-08-14T12:57:17Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
dc.title.alternative.pt_BR.fl_str_mv 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
title 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
spellingShingle 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
Farias, Pablo Felipe Ferreira
12-HSA
curcumin
self-assembly
12-Hydroxystearic acid
title_short 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
title_full 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
title_fullStr 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
title_full_unstemmed 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
title_sort 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
author Farias, Pablo Felipe Ferreira
author_facet Farias, Pablo Felipe Ferreira
author_role author
dc.contributor.referees1.none.fl_str_mv Egito, Eryvaldo Sócrates Tabosa do
dc.contributor.referees2.none.fl_str_mv Marcelino, Henrique Rodrigues
dc.contributor.referees3.none.fl_str_mv Azevedo, Eduardo Pereira de
dc.contributor.author.fl_str_mv Farias, Pablo Felipe Ferreira
dc.contributor.advisor-co1.fl_str_mv Douglas Dourado Oliveira
dc.contributor.advisor1.fl_str_mv Egito, Eryvaldo Sócrates Tabosa do
contributor_str_mv Douglas Dourado Oliveira
Egito, Eryvaldo Sócrates Tabosa do
dc.subject.por.fl_str_mv 12-HSA
curcumin
self-assembly
12-Hydroxystearic acid
topic 12-HSA
curcumin
self-assembly
12-Hydroxystearic acid
description Capes e CNPq
publishDate 2020
dc.date.accessioned.fl_str_mv 2020-07-24T13:53:03Z
2021-09-20T17:52:26Z
dc.date.available.fl_str_mv 2020-07-24T13:53:03Z
dc.date.issued.fl_str_mv 2020-07-10
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/bachelorThesis
format bachelorThesis
status_str publishedVersion
dc.identifier.pt_BR.fl_str_mv 20160127641
dc.identifier.citation.fl_str_mv FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/35820
identifier_str_mv 20160127641
FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.
url https://repositorio.ufrn.br/handle/123456789/35820
dc.language.iso.fl_str_mv por
language por
dc.rights.driver.fl_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution-NonCommercial-NoDerivs 3.0 Brazil
http://creativecommons.org/licenses/by-nc-nd/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.publisher.initials.fl_str_mv UFRN
dc.publisher.country.fl_str_mv Brasil
dc.publisher.department.fl_str_mv Fármacia
publisher.none.fl_str_mv Universidade Federal do Rio Grande do Norte
dc.source.none.fl_str_mv reponame:Repositório Institucional da UFRN
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