12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach
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Data de Publicação: | 2020 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/35820 |
Resumo: | Capes e CNPq |
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Farias, Pablo Felipe FerreiraDouglas Dourado OliveiraEgito, Eryvaldo Sócrates Tabosa doMarcelino, Henrique RodriguesAzevedo, Eduardo Pereira deEgito, Eryvaldo Sócrates Tabosa do2020-07-24T13:53:03Z2021-09-20T17:52:26Z2020-07-24T13:53:03Z2020-07-1020160127641FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020.https://repositorio.ufrn.br/handle/123456789/35820Capes e CNPq12-Hydroxystearic acid (12-HSA)-based organogels are self-assembled systems that allow trapping organic solvents, such as natural oils. Therefore, they are excellent choice in the pharmaceutical field to load lipophilic molecules. Based on this, the aim of this study was to obtain 12-HSA-based organogels loading curcumin at different concentrations of the organogelator (2, 5 and 10 % w / w) in Miglyol ® 812 N, a medium chain triglyceride widely used in the pharmaceutical field. The physicochemical, thermal and mechanical properties of the produced organogels were elucidated by techniques, such as FTIR, XRD, visual sol-gel temperature transition and texture analysis. The characterization assays revealed that the organogels have an amorphous due to the oil composition. It also demonstrated that the model molecule, curcumin, was solubilized in the oil, which was entrapped by the crystalline matrix. Additionally, the thermal profile of the systems at different 12-HSA concentrations demonstrated the thermoreversible property of the gels and the addition of curcumin did not interfere in this property, which in general it may suggest a thermal stability profile that allows its storage at high temperatures. The mechanical profile results pointed out the possibility of use in several administration routes depending on the gelling agent concentration. Thereafter, it was possible to verify that the addition of the drug did not change the physicochemical and mechanical properties of the 12-HSA organogels, suggesting that this system is able to trap other drug other drug candidates. In view of these results, it is noteworthy the versatility of such organogels based on their amorphous nature and variable hardness, which could preclude their use in different field applications. The system could also become a viable delivery system to a wide range of drugs once they do not interfere on their characteristics. Therefore, for its future use, additional release, safety and biological activity studies need to be carried out.Universidade Federal do Rio Grande do NorteUFRNBrasilFármaciaAttribution-NonCommercial-NoDerivs 3.0 Brazilhttp://creativecommons.org/licenses/by-nc-nd/3.0/br/info:eu-repo/semantics/openAccess12-HSAcurcuminself-assembly12-Hydroxystearic acid12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approachinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisporreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINAL12Hydroxystearicacidbasedorganogel_Farias_2020Texto Completoapplication/pdf828611https://repositorio.ufrn.br/bitstream/123456789/35820/1/12Hydroxystearicacidbasedorganogel_Farias_2020bca836d438e87790e126ea0e880e78a8MD51CC-LICENSElicense_rdfapplication/pdf811https://repositorio.ufrn.br/bitstream/123456789/35820/2/license_rdfe39d27027a6cc9cb039ad269a5db8e34MD52LICENSElicense.txttext/plain714https://repositorio.ufrn.br/bitstream/123456789/35820/3/license.txt7278bab9c5c886812fa7d225dc807888MD53TEXT12Hydroxystearicacidbasedorganogel_Farias_2020.txtExtracted texttext/plain60524https://repositorio.ufrn.br/bitstream/123456789/35820/4/12Hydroxystearicacidbasedorganogel_Farias_2020.txt76783bbc34e90a7eecb6380755449fcbMD54123456789/358202023-08-14 09:57:17.942oai:https://repositorio.ufrn.br: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ório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-08-14T12:57:17Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
dc.title.alternative.pt_BR.fl_str_mv |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
title |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
spellingShingle |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach Farias, Pablo Felipe Ferreira 12-HSA curcumin self-assembly 12-Hydroxystearic acid |
title_short |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
title_full |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
title_fullStr |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
title_full_unstemmed |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
title_sort |
12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach |
author |
Farias, Pablo Felipe Ferreira |
author_facet |
Farias, Pablo Felipe Ferreira |
author_role |
author |
dc.contributor.referees1.none.fl_str_mv |
Egito, Eryvaldo Sócrates Tabosa do |
dc.contributor.referees2.none.fl_str_mv |
Marcelino, Henrique Rodrigues |
dc.contributor.referees3.none.fl_str_mv |
Azevedo, Eduardo Pereira de |
dc.contributor.author.fl_str_mv |
Farias, Pablo Felipe Ferreira |
dc.contributor.advisor-co1.fl_str_mv |
Douglas Dourado Oliveira |
dc.contributor.advisor1.fl_str_mv |
Egito, Eryvaldo Sócrates Tabosa do |
contributor_str_mv |
Douglas Dourado Oliveira Egito, Eryvaldo Sócrates Tabosa do |
dc.subject.por.fl_str_mv |
12-HSA curcumin self-assembly 12-Hydroxystearic acid |
topic |
12-HSA curcumin self-assembly 12-Hydroxystearic acid |
description |
Capes e CNPq |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-07-24T13:53:03Z 2021-09-20T17:52:26Z |
dc.date.available.fl_str_mv |
2020-07-24T13:53:03Z |
dc.date.issued.fl_str_mv |
2020-07-10 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.pt_BR.fl_str_mv |
20160127641 |
dc.identifier.citation.fl_str_mv |
FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/35820 |
identifier_str_mv |
20160127641 FARIAS, Pablo Felipe Ferreira. 12-Hydroxystearic acid-based organogel as a matrix for hydrophobic drugs intended for topical use: a physicochemical approach. 2020. 32 f. Trabalho de Conclusão de Curso (Graduação em Farmácia) - Departamento de Farmácia, Universidade Federal do Rio Grande do Norte, Natal, 2020. |
url |
https://repositorio.ufrn.br/handle/123456789/35820 |
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por |
language |
por |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution-NonCommercial-NoDerivs 3.0 Brazil http://creativecommons.org/licenses/by-nc-nd/3.0/br/ |
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openAccess |
dc.publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
dc.publisher.initials.fl_str_mv |
UFRN |
dc.publisher.country.fl_str_mv |
Brasil |
dc.publisher.department.fl_str_mv |
Fármacia |
publisher.none.fl_str_mv |
Universidade Federal do Rio Grande do Norte |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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