Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol

Detalhes bibliográficos
Autor(a) principal: Morais, Ana Heloneida de Araujo
Data de Publicação: 2019
Outros Autores: Medeiros, Amanda Fernandes de, Costa, Izael de Sousa, Piuvezam, Grasiela, Medeiros, Gidyenne Christine Bandeira Silva de, Maciel, Bruna Leal Lima
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UFRN
Texto Completo: https://repositorio.ufrn.br/handle/123456789/54701
http://dx.doi.org/10.1097/MD.0000000000017326
Resumo: Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2
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spelling Morais, Ana Heloneida de AraujoMedeiros, Amanda Fernandes deCosta, Izael de SousaPiuvezam, GrasielaMedeiros, Gidyenne Christine Bandeira Silva deMaciel, Bruna Leal Limahttps://orcid.org/0000-0002-6460-911X2023-09-05T20:50:04Z2023-09-05T20:50:04Z2019MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54701http://dx.doi.org/10.1097/MD.0000000000017326MedicineAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessAntidiabetic peptidediabetes mellitushypoglycemic agentssystematic reviewtype 2 diabetes mellitus.vegetable proteinsMechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMechanismof theactionBioactive_Medeiros_2019.pdfMechanismof theactionBioactive_Medeiros_2019.pdfapplication/pdf321787https://repositorio.ufrn.br/bitstream/123456789/54701/1/Mechanismof%20theactionBioactive_Medeiros_2019.pdff4bd915351c44b85f1685db32355e492MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54701/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54701/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/547012023-09-05 17:51:21.278oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-09-05T20:51:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false
dc.title.pt_BR.fl_str_mv Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
title Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
spellingShingle Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
Morais, Ana Heloneida de Araujo
Antidiabetic peptide
diabetes mellitus
hypoglycemic agents
systematic review
type 2 diabetes mellitus.
vegetable proteins
title_short Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
title_full Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
title_fullStr Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
title_full_unstemmed Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
title_sort Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
author Morais, Ana Heloneida de Araujo
author_facet Morais, Ana Heloneida de Araujo
Medeiros, Amanda Fernandes de
Costa, Izael de Sousa
Piuvezam, Grasiela
Medeiros, Gidyenne Christine Bandeira Silva de
Maciel, Bruna Leal Lima
author_role author
author2 Medeiros, Amanda Fernandes de
Costa, Izael de Sousa
Piuvezam, Grasiela
Medeiros, Gidyenne Christine Bandeira Silva de
Maciel, Bruna Leal Lima
author2_role author
author
author
author
author
dc.contributor.authorID.pt_BR.fl_str_mv https://orcid.org/0000-0002-6460-911X
dc.contributor.author.fl_str_mv Morais, Ana Heloneida de Araujo
Medeiros, Amanda Fernandes de
Costa, Izael de Sousa
Piuvezam, Grasiela
Medeiros, Gidyenne Christine Bandeira Silva de
Maciel, Bruna Leal Lima
dc.subject.por.fl_str_mv Antidiabetic peptide
diabetes mellitus
hypoglycemic agents
systematic review
type 2 diabetes mellitus.
vegetable proteins
topic Antidiabetic peptide
diabetes mellitus
hypoglycemic agents
systematic review
type 2 diabetes mellitus.
vegetable proteins
description Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2
publishDate 2019
dc.date.issued.fl_str_mv 2019
dc.date.accessioned.fl_str_mv 2023-09-05T20:50:04Z
dc.date.available.fl_str_mv 2023-09-05T20:50:04Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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status_str publishedVersion
dc.identifier.citation.fl_str_mv MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023.
dc.identifier.uri.fl_str_mv https://repositorio.ufrn.br/handle/123456789/54701
dc.identifier.doi.none.fl_str_mv http://dx.doi.org/10.1097/MD.0000000000017326
identifier_str_mv MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023.
url https://repositorio.ufrn.br/handle/123456789/54701
http://dx.doi.org/10.1097/MD.0000000000017326
dc.language.iso.fl_str_mv eng
language eng
dc.rights.driver.fl_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
info:eu-repo/semantics/openAccess
rights_invalid_str_mv Attribution 3.0 Brazil
http://creativecommons.org/licenses/by/3.0/br/
eu_rights_str_mv openAccess
dc.publisher.none.fl_str_mv Medicine
publisher.none.fl_str_mv Medicine
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