Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54701 http://dx.doi.org/10.1097/MD.0000000000017326 |
Resumo: | Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2 |
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Morais, Ana Heloneida de AraujoMedeiros, Amanda Fernandes deCosta, Izael de SousaPiuvezam, GrasielaMedeiros, Gidyenne Christine Bandeira Silva deMaciel, Bruna Leal Limahttps://orcid.org/0000-0002-6460-911X2023-09-05T20:50:04Z2023-09-05T20:50:04Z2019MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54701http://dx.doi.org/10.1097/MD.0000000000017326MedicineAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessAntidiabetic peptidediabetes mellitushypoglycemic agentssystematic reviewtype 2 diabetes mellitus.vegetable proteinsMechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleBackground: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMechanismof theactionBioactive_Medeiros_2019.pdfMechanismof theactionBioactive_Medeiros_2019.pdfapplication/pdf321787https://repositorio.ufrn.br/bitstream/123456789/54701/1/Mechanismof%20theactionBioactive_Medeiros_2019.pdff4bd915351c44b85f1685db32355e492MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/54701/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54701/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/547012023-09-05 17:51:21.278oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-09-05T20:51:21Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
title |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
spellingShingle |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol Morais, Ana Heloneida de Araujo Antidiabetic peptide diabetes mellitus hypoglycemic agents systematic review type 2 diabetes mellitus. vegetable proteins |
title_short |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
title_full |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
title_fullStr |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
title_full_unstemmed |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
title_sort |
Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: systematic review protocol |
author |
Morais, Ana Heloneida de Araujo |
author_facet |
Morais, Ana Heloneida de Araujo Medeiros, Amanda Fernandes de Costa, Izael de Sousa Piuvezam, Grasiela Medeiros, Gidyenne Christine Bandeira Silva de Maciel, Bruna Leal Lima |
author_role |
author |
author2 |
Medeiros, Amanda Fernandes de Costa, Izael de Sousa Piuvezam, Grasiela Medeiros, Gidyenne Christine Bandeira Silva de Maciel, Bruna Leal Lima |
author2_role |
author author author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-6460-911X |
dc.contributor.author.fl_str_mv |
Morais, Ana Heloneida de Araujo Medeiros, Amanda Fernandes de Costa, Izael de Sousa Piuvezam, Grasiela Medeiros, Gidyenne Christine Bandeira Silva de Maciel, Bruna Leal Lima |
dc.subject.por.fl_str_mv |
Antidiabetic peptide diabetes mellitus hypoglycemic agents systematic review type 2 diabetes mellitus. vegetable proteins |
topic |
Antidiabetic peptide diabetes mellitus hypoglycemic agents systematic review type 2 diabetes mellitus. vegetable proteins |
description |
Background: Diabetes mellitus type 2 (DM2) is a chronic disease of significant prevalence causing hyperglycemia and several comorbidities. Evidences highlight the performance of non - protein bioactive compounds found in vegetables in the control of hyperglycemia. This study describes a protocol of a systematic review, which analyzes the action of proteins and bioactive peptides of plants in DM2. Methods: The Preferred Reporting Items guide this protocol for Systematic Reviews and Meta-Analyzes Protocols (PRISMA-P) was used. The databases that will be used for searching will be PubMed, ScienceDirect, Scopus, Web of Science, EMBASE, and Virtual Health Library, Brazil (VHL). Studies that use bioactive proteins and peptides of vegetal origin in DM2 will be included in the systematic review. The studies will be identified using clinical parameters and the effect on insulin resistance. The characteristics of the studies as control groups, test substance, dosage, intervention time, and the main results will be described. Selection of studies, data extraction, and methodological quality assessment will be performed independently by two experienced reviewers. Results: This protocol will be the basis for a systematic review identifying the mechanism of action of plant proteins and peptides in type 2 diabetes mellitus. Conclusion: Systematic reviews from this protocol will provide support for the construction of researches that analyze the effect of plant bioactive proteins and peptides on the control of hyperglycemia and how these molecules act in the control of DM2 |
publishDate |
2019 |
dc.date.issued.fl_str_mv |
2019 |
dc.date.accessioned.fl_str_mv |
2023-09-05T20:50:04Z |
dc.date.available.fl_str_mv |
2023-09-05T20:50:04Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
format |
article |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54701 |
dc.identifier.doi.none.fl_str_mv |
http://dx.doi.org/10.1097/MD.0000000000017326 |
identifier_str_mv |
MEDEIROS, A. F. et al. Mechanism of the action of bioactive proteins of vegetables in diabetes mellitus type 2: Systematic review protocol. Medicine, v. 98, n. 39, p. e17326-e17326, 2019. Disponível em: https://journals.lww.com/md-journal/Fulltext/2019/09270/Mechanism_of_the_action_of_bioactive_proteins_of.76.aspx. Acesso em: 7 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54701 http://dx.doi.org/10.1097/MD.0000000000017326 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Medicine |
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Medicine |
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