Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex
Autor(a) principal: | |
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Data de Publicação: | 2023 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/52022 |
Resumo: | Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath. Here, we investigated the mechanisms and functions of gamma oscillations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing and how they relate to local spiking activity. Mechanistically, we find that respiration drives gamma oscillations in the piriform cortex, which correlate with local feedback inhibition and result from recurrent connections between local excitatory and inhibitory neuronal populations. Moreover, respiration-driven gamma oscillations are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished during ketamine/xylazine anesthesia. Functionally, we demonstrate that they locally segregate neuronal assemblies through a winner-take-all computation leading to sparse odor coding during each breathing cycle. Our results shed new light on the mechanisms of gamma oscillations, bridging computation, cognition, and physiology |
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Gonzalez, JoaquinTorterolo, PabloTort, Adriano Bretanha Lopes2023-04-04T12:47:35Z2023-04-04T12:47:35Z2023-02GONZALEZ, Joaquin; TORTEROLO, Pablo; TORT, Adriano BL. Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex. Elife, [S. l.], v. 12, p. e83044, fev. 2023. Doi: http://dx.doi.org/10.7554/elife.83044. Disponível em: https://elifesciences.org/articles/83044. Acesso em: 04 abr. 2023.https://repositorio.ufrn.br/handle/123456789/5202210.7554/eLife.83044ELife Sciences Publications, LtdAtribuição 3.0 Brasilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessGamma oscillations - RespirationPiriform cortex - MiceNeural oscillationsMechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortexinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleGamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath. Here, we investigated the mechanisms and functions of gamma oscillations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing and how they relate to local spiking activity. Mechanistically, we find that respiration drives gamma oscillations in the piriform cortex, which correlate with local feedback inhibition and result from recurrent connections between local excitatory and inhibitory neuronal populations. Moreover, respiration-driven gamma oscillations are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished during ketamine/xylazine anesthesia. Functionally, we demonstrate that they locally segregate neuronal assemblies through a winner-take-all computation leading to sparse odor coding during each breathing cycle. Our results shed new light on the mechanisms of gamma oscillations, bridging computation, cognition, and physiologyengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALMechanismsFunctionsRespiration_Tort_2023.pdfMechanismsFunctionsRespiration_Tort_2023.pdfMechanismsFunctionsRespiration_Tort_2023application/pdf11739807https://repositorio.ufrn.br/bitstream/123456789/52022/1/MechanismsFunctionsRespiration_Tort_2023.pdf959bcf1096b227012662da8299aa5c2eMD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/52022/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/52022/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/520222023-04-04 09:47:36.465oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-04-04T12:47:36Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
title |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
spellingShingle |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex Gonzalez, Joaquin Gamma oscillations - Respiration Piriform cortex - Mice Neural oscillations |
title_short |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
title_full |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
title_fullStr |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
title_full_unstemmed |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
title_sort |
Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex |
author |
Gonzalez, Joaquin |
author_facet |
Gonzalez, Joaquin Torterolo, Pablo Tort, Adriano Bretanha Lopes |
author_role |
author |
author2 |
Torterolo, Pablo Tort, Adriano Bretanha Lopes |
author2_role |
author author |
dc.contributor.author.fl_str_mv |
Gonzalez, Joaquin Torterolo, Pablo Tort, Adriano Bretanha Lopes |
dc.subject.por.fl_str_mv |
Gamma oscillations - Respiration Piriform cortex - Mice Neural oscillations |
topic |
Gamma oscillations - Respiration Piriform cortex - Mice Neural oscillations |
description |
Gamma oscillations are believed to underlie cognitive processes by shaping the formation of transient neuronal partnerships on a millisecond scale. These oscillations are coupled to the phase of breathing cycles in several brain areas, possibly reflecting local computations driven by sensory inputs sampled at each breath. Here, we investigated the mechanisms and functions of gamma oscillations in the piriform (olfactory) cortex of awake mice to understand their dependence on breathing and how they relate to local spiking activity. Mechanistically, we find that respiration drives gamma oscillations in the piriform cortex, which correlate with local feedback inhibition and result from recurrent connections between local excitatory and inhibitory neuronal populations. Moreover, respiration-driven gamma oscillations are triggered by the activation of mitral/tufted cells in the olfactory bulb and are abolished during ketamine/xylazine anesthesia. Functionally, we demonstrate that they locally segregate neuronal assemblies through a winner-take-all computation leading to sparse odor coding during each breathing cycle. Our results shed new light on the mechanisms of gamma oscillations, bridging computation, cognition, and physiology |
publishDate |
2023 |
dc.date.accessioned.fl_str_mv |
2023-04-04T12:47:35Z |
dc.date.available.fl_str_mv |
2023-04-04T12:47:35Z |
dc.date.issued.fl_str_mv |
2023-02 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
GONZALEZ, Joaquin; TORTEROLO, Pablo; TORT, Adriano BL. Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex. Elife, [S. l.], v. 12, p. e83044, fev. 2023. Doi: http://dx.doi.org/10.7554/elife.83044. Disponível em: https://elifesciences.org/articles/83044. Acesso em: 04 abr. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/52022 |
dc.identifier.doi.none.fl_str_mv |
10.7554/eLife.83044 |
identifier_str_mv |
GONZALEZ, Joaquin; TORTEROLO, Pablo; TORT, Adriano BL. Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex. Elife, [S. l.], v. 12, p. e83044, fev. 2023. Doi: http://dx.doi.org/10.7554/elife.83044. Disponível em: https://elifesciences.org/articles/83044. Acesso em: 04 abr. 2023. 10.7554/eLife.83044 |
url |
https://repositorio.ufrn.br/handle/123456789/52022 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
Atribuição 3.0 Brasil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
Atribuição 3.0 Brasil http://creativecommons.org/licenses/by/3.0/br/ |
eu_rights_str_mv |
openAccess |
dc.publisher.none.fl_str_mv |
ELife Sciences Publications, Ltd |
publisher.none.fl_str_mv |
ELife Sciences Publications, Ltd |
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reponame:Repositório Institucional da UFRN instname:Universidade Federal do Rio Grande do Norte (UFRN) instacron:UFRN |
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Repositório Institucional da UFRN |
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