Correlation between cell cycle proteins and hMSH2 in actinic cheilitis and lip cancer

• Autor(a) principal: Lopes, Maria Luiza Diniz de Sousa
• Data de Publicação: 2016
• Outros Autores: Oliveira, Denise Hélen Imaculada Pereira de, Sarmento, Dmitry José de Santana, Queiroz, Lelia Maria Guedes, Miguel, Marcia Cristina da Costa, Silveira, Ericka Janine Dantas da
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UFRN
• Texto Completo: https://repositorio.ufrn.br/jspui/handle/123456789/21849
• topic: Actinic cheilitis; Squamous cell carcinoma; Lip carcinogenesis; Oral cancer

This study aims to evaluate and verify the relationship between the immunoexpression of hMSH2, p53 and p21 in actinic cheilitis (AC) and lower lip squamous cell carcinoma (SCC) cases. Forty AC and 40 SCC cases were submitted to immunoperoxidase method and quantitatively analyzed. Expression was compared by Mann–Whitney test, Student t test or one-way ANOVA. To correlate the variables, Pearson’s correlation coefficient was calculated. The expression of p53 and p21 showed no significant differences between histopathological grades of AC or lower lip SCC (p > 0.05). Immunoexpression of p53 was higher in SCC than in AC (p < 0.001), while p21 expression was more observed in AC when compared to SCC group (p = 0.006). The AC group revealed an inverse correlation between p53 and hMSH2 expression (r = −0.30, p = 0.006). Alterations in p53 and p21 expression suggest that these proteins are involved in lower lip carcinogenesis. Moreover, p53 and hMSH2 seem to be interrelated in early events of this process.