Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B
Autor(a) principal: | |
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Data de Publicação: | 1999 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31099 |
Resumo: | Retinal projections in vertebrates reach the primary visual, accessory optic, and circadian timing structures. The central feature of the circadian timing system is the principal circadian pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus. The direct projections from the retina to the SCN are considered the entrainment pathway of the circadian timing system. In this study, unilateral intravitreal injections of cholera toxin subunit B were used to trace the retinal projections to the marmoset hypothalamus. The retinohypothalamic tract reaches the ventral suprachiasmatic nucleus bilaterally, as anticipated from previous studies. However, labeled fibers were found in several other hypothalamic regions, such as the medial and lateral preoptic areas, supraoptic nucleus, anterior and lateral hypothalamic areas, retrochiasmatic area, and subparaventricular zone. These results reveal new aspects of retinohypothalamic projection in primates and are discussed in terms of their implications for circadian as well as noncircadian control systems. |
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Costa, Mirian Stela Maris de OliveiraSantee, U. R.Cavalcante, J. S.Moraes, Paulo Ranieri de AraújoSantos, N. P.Britto, L. R. G.2020-12-22T11:38:38Z2020-12-22T11:38:38Z1999-08-25COSTA, Mirian Stela Maris de Oliveira; SANTEE, U. R.; CAVALCANTE, J. S.; MORAES, Paulo Raniere de Araujo; SANTOS, N. P.; BRITTO, L. R. G. Retinohypothalamic projections in the common marmoset (Callithrix jacchus): a study using cholera toxin subunit b. The Journal Of Comparative Neurology, [s. l.], v. 415, n. 3, p. 393-403, 20 dez. 1999. Wiley. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9861(19991220)415:3%3C393::AID-CNE5%3E3.0.CO;2-R. Acesso em: 26 out. 2020. http://dx.doi.org/10.1002/(sici)1096-9861(19991220)415:33.0.co;2-r.1096-9861 (online)0021-9967 (print)https://repositorio.ufrn.br/handle/123456789/31099WileyAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessCircadian rhythmsSuprachiasmatic nucleusSubcortical visual pathwaysHypothalamic nucleiRetinohypothalamic tractRetinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit Binfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleRetinal projections in vertebrates reach the primary visual, accessory optic, and circadian timing structures. The central feature of the circadian timing system is the principal circadian pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus. The direct projections from the retina to the SCN are considered the entrainment pathway of the circadian timing system. In this study, unilateral intravitreal injections of cholera toxin subunit B were used to trace the retinal projections to the marmoset hypothalamus. The retinohypothalamic tract reaches the ventral suprachiasmatic nucleus bilaterally, as anticipated from previous studies. However, labeled fibers were found in several other hypothalamic regions, such as the medial and lateral preoptic areas, supraoptic nucleus, anterior and lateral hypothalamic areas, retrochiasmatic area, and subparaventricular zone. These results reveal new aspects of retinohypothalamic projection in primates and are discussed in terms of their implications for circadian as well as noncircadian control systems.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNCC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31099/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31099/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTRetinohypothalamicProjectionsCommon_Moraes_1999.pdf.txtRetinohypothalamicProjectionsCommon_Moraes_1999.pdf.txtExtracted texttext/plain44751https://repositorio.ufrn.br/bitstream/123456789/31099/4/RetinohypothalamicProjectionsCommon_Moraes_1999.pdf.txtb1f8de8608b4b62a481e67e48a360f6bMD54THUMBNAILRetinohypothalamicProjectionsCommon_Moraes_1999.pdf.jpgRetinohypothalamicProjectionsCommon_Moraes_1999.pdf.jpgGenerated Thumbnailimage/jpeg1738https://repositorio.ufrn.br/bitstream/123456789/31099/5/RetinohypothalamicProjectionsCommon_Moraes_1999.pdf.jpg765957f31d32210cd07f6b8fb1fcc893MD55123456789/310992022-05-25 16:19:54.631oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2022-05-25T19:19:54Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
title |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
spellingShingle |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B Costa, Mirian Stela Maris de Oliveira Circadian rhythms Suprachiasmatic nucleus Subcortical visual pathways Hypothalamic nuclei Retinohypothalamic tract |
title_short |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
title_full |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
title_fullStr |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
title_full_unstemmed |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
title_sort |
Retinohypothalamic projections in the Common Marmoset (Callithrix jacchus): a study using cholera toxin subunit B |
author |
Costa, Mirian Stela Maris de Oliveira |
author_facet |
Costa, Mirian Stela Maris de Oliveira Santee, U. R. Cavalcante, J. S. Moraes, Paulo Ranieri de Araújo Santos, N. P. Britto, L. R. G. |
author_role |
author |
author2 |
Santee, U. R. Cavalcante, J. S. Moraes, Paulo Ranieri de Araújo Santos, N. P. Britto, L. R. G. |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Costa, Mirian Stela Maris de Oliveira Santee, U. R. Cavalcante, J. S. Moraes, Paulo Ranieri de Araújo Santos, N. P. Britto, L. R. G. |
dc.subject.por.fl_str_mv |
Circadian rhythms Suprachiasmatic nucleus Subcortical visual pathways Hypothalamic nuclei Retinohypothalamic tract |
topic |
Circadian rhythms Suprachiasmatic nucleus Subcortical visual pathways Hypothalamic nuclei Retinohypothalamic tract |
description |
Retinal projections in vertebrates reach the primary visual, accessory optic, and circadian timing structures. The central feature of the circadian timing system is the principal circadian pacemaker, the suprachiasmatic nucleus (SCN) of the hypothalamus. The direct projections from the retina to the SCN are considered the entrainment pathway of the circadian timing system. In this study, unilateral intravitreal injections of cholera toxin subunit B were used to trace the retinal projections to the marmoset hypothalamus. The retinohypothalamic tract reaches the ventral suprachiasmatic nucleus bilaterally, as anticipated from previous studies. However, labeled fibers were found in several other hypothalamic regions, such as the medial and lateral preoptic areas, supraoptic nucleus, anterior and lateral hypothalamic areas, retrochiasmatic area, and subparaventricular zone. These results reveal new aspects of retinohypothalamic projection in primates and are discussed in terms of their implications for circadian as well as noncircadian control systems. |
publishDate |
1999 |
dc.date.issued.fl_str_mv |
1999-08-25 |
dc.date.accessioned.fl_str_mv |
2020-12-22T11:38:38Z |
dc.date.available.fl_str_mv |
2020-12-22T11:38:38Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
COSTA, Mirian Stela Maris de Oliveira; SANTEE, U. R.; CAVALCANTE, J. S.; MORAES, Paulo Raniere de Araujo; SANTOS, N. P.; BRITTO, L. R. G. Retinohypothalamic projections in the common marmoset (Callithrix jacchus): a study using cholera toxin subunit b. The Journal Of Comparative Neurology, [s. l.], v. 415, n. 3, p. 393-403, 20 dez. 1999. Wiley. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9861(19991220)415:3%3C393::AID-CNE5%3E3.0.CO;2-R. Acesso em: 26 out. 2020. http://dx.doi.org/10.1002/(sici)1096-9861(19991220)415:33.0.co;2-r. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31099 |
dc.identifier.issn.none.fl_str_mv |
1096-9861 (online) 0021-9967 (print) |
identifier_str_mv |
COSTA, Mirian Stela Maris de Oliveira; SANTEE, U. R.; CAVALCANTE, J. S.; MORAES, Paulo Raniere de Araujo; SANTOS, N. P.; BRITTO, L. R. G. Retinohypothalamic projections in the common marmoset (Callithrix jacchus): a study using cholera toxin subunit b. The Journal Of Comparative Neurology, [s. l.], v. 415, n. 3, p. 393-403, 20 dez. 1999. Wiley. Disponível em: https://onlinelibrary.wiley.com/doi/10.1002/(SICI)1096-9861(19991220)415:3%3C393::AID-CNE5%3E3.0.CO;2-R. Acesso em: 26 out. 2020. http://dx.doi.org/10.1002/(sici)1096-9861(19991220)415:33.0.co;2-r. 1096-9861 (online) 0021-9967 (print) |
url |
https://repositorio.ufrn.br/handle/123456789/31099 |
dc.language.iso.fl_str_mv |
eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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Wiley |
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Wiley |
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