Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/jspui/handle/123456789/28384 |
Resumo: | Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect. Using microwire electrode arrays, we recorded local field potential in young (4-5- month-old) and old (11-13-month-old) mice to study the electrophysiological effect of tinnitus in the ventral hippocampus (vHipp) and medial prefrontal cortex (mPFC) in an open field arena and elevated plus maze 1h after salicylate (300mg/kg) injection. We found that anxiety-like behavior and increase in theta2 oscillations (4-6 Hz), following salicylate pre-treatment, only occurs in young (normal hearing) mice. We also show that theta2 and slow gamma oscillations increase in the vHipp and mPFC in a complementary manner during anxiety tests in the presence of salicylate. Finally, we show that pre-treating mice with a single dose of the hallucinogenic 5-MeO-DMT prevents anxiety-like behavior and the increase in theta2 and slow gamma oscillations after salicylate injection in normal hearing young mice. This work further support the hypothesis that anxiety-like behavior after salicylate injection is triggered by tinnitus and require normal hearing. Moreover, our results show that hallucinogenic compounds can be effective in treating tinnitus-related anxiety. |
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Winne, JessicaBoerner, Barbara C.Malfatti, ThawannBrisa, ElisDoerl, JhulimarNogueira, IngridLeão, Emelie Katarina SvahnLeão, Richardson Naves2020-01-24T19:32:55Z2020-01-24T19:32:55Z2020-01-08WINNE, J.; BOERNER, B. C.; MALFATTI, T.; BRISA, E.; DOERL, J.; NOGUEIRA, I.; LEÃO, K. E.; LEÃO, R. N. Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT. Exp Neurol., [s. l.], v. 326, p. 113175, jan. 2020.https://repositorio.ufrn.br/jspui/handle/123456789/2838410.1016/j.expneurol.2020.1131755-MeO-DMT and anxietyTinnitusType 2 thetaVentral hippocampusAnxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMTinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSalicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect. Using microwire electrode arrays, we recorded local field potential in young (4-5- month-old) and old (11-13-month-old) mice to study the electrophysiological effect of tinnitus in the ventral hippocampus (vHipp) and medial prefrontal cortex (mPFC) in an open field arena and elevated plus maze 1h after salicylate (300mg/kg) injection. We found that anxiety-like behavior and increase in theta2 oscillations (4-6 Hz), following salicylate pre-treatment, only occurs in young (normal hearing) mice. We also show that theta2 and slow gamma oscillations increase in the vHipp and mPFC in a complementary manner during anxiety tests in the presence of salicylate. Finally, we show that pre-treating mice with a single dose of the hallucinogenic 5-MeO-DMT prevents anxiety-like behavior and the increase in theta2 and slow gamma oscillations after salicylate injection in normal hearing young mice. This work further support the hypothesis that anxiety-like behavior after salicylate injection is triggered by tinnitus and require normal hearing. Moreover, our results show that hallucinogenic compounds can be effective in treating tinnitus-related anxiety.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessLICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/28384/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52TEXTRichardsonLeao_ICe_2020_Anxiety-like behavior.pdf.txtRichardsonLeao_ICe_2020_Anxiety-like behavior.pdf.txtExtracted texttext/plain79726https://repositorio.ufrn.br/bitstream/123456789/28384/3/RichardsonLeao_ICe_2020_Anxiety-like%20behavior.pdf.txta4f8b420211a5e57d2e91402daa505aaMD53THUMBNAILRichardsonLeao_ICe_2020_Anxiety-like behavior.pdf.jpgRichardsonLeao_ICe_2020_Anxiety-like behavior.pdf.jpgGenerated Thumbnailimage/jpeg1687https://repositorio.ufrn.br/bitstream/123456789/28384/4/RichardsonLeao_ICe_2020_Anxiety-like%20behavior.pdf.jpgb7a80e2d621f1ecf21d0d91dc2e6920aMD54123456789/283842023-02-06 15:34:34.792oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-02-06T18:34:34Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
title |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
spellingShingle |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT Winne, Jessica 5-MeO-DMT and anxiety Tinnitus Type 2 theta Ventral hippocampus |
title_short |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
title_full |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
title_fullStr |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
title_full_unstemmed |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
title_sort |
Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT |
author |
Winne, Jessica |
author_facet |
Winne, Jessica Boerner, Barbara C. Malfatti, Thawann Brisa, Elis Doerl, Jhulimar Nogueira, Ingrid Leão, Emelie Katarina Svahn Leão, Richardson Naves |
author_role |
author |
author2 |
Boerner, Barbara C. Malfatti, Thawann Brisa, Elis Doerl, Jhulimar Nogueira, Ingrid Leão, Emelie Katarina Svahn Leão, Richardson Naves |
author2_role |
author author author author author author author |
dc.contributor.author.fl_str_mv |
Winne, Jessica Boerner, Barbara C. Malfatti, Thawann Brisa, Elis Doerl, Jhulimar Nogueira, Ingrid Leão, Emelie Katarina Svahn Leão, Richardson Naves |
dc.subject.por.fl_str_mv |
5-MeO-DMT and anxiety Tinnitus Type 2 theta Ventral hippocampus |
topic |
5-MeO-DMT and anxiety Tinnitus Type 2 theta Ventral hippocampus |
description |
Salicylate intoxication is a cause of tinnitus and comorbidly associated with anxiety in humans. In a previous work, we showed that salicylate induces anxiety-like behavior and hippocampal type 2 theta oscillations (theta2) in mice. Here we investigate if the anxiogenic effect of salicylate is dependent on age and previous tinnitus experience. We also tested whether a single dose of DMT can prevent this effect. Using microwire electrode arrays, we recorded local field potential in young (4-5- month-old) and old (11-13-month-old) mice to study the electrophysiological effect of tinnitus in the ventral hippocampus (vHipp) and medial prefrontal cortex (mPFC) in an open field arena and elevated plus maze 1h after salicylate (300mg/kg) injection. We found that anxiety-like behavior and increase in theta2 oscillations (4-6 Hz), following salicylate pre-treatment, only occurs in young (normal hearing) mice. We also show that theta2 and slow gamma oscillations increase in the vHipp and mPFC in a complementary manner during anxiety tests in the presence of salicylate. Finally, we show that pre-treating mice with a single dose of the hallucinogenic 5-MeO-DMT prevents anxiety-like behavior and the increase in theta2 and slow gamma oscillations after salicylate injection in normal hearing young mice. This work further support the hypothesis that anxiety-like behavior after salicylate injection is triggered by tinnitus and require normal hearing. Moreover, our results show that hallucinogenic compounds can be effective in treating tinnitus-related anxiety. |
publishDate |
2020 |
dc.date.accessioned.fl_str_mv |
2020-01-24T19:32:55Z |
dc.date.available.fl_str_mv |
2020-01-24T19:32:55Z |
dc.date.issued.fl_str_mv |
2020-01-08 |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
WINNE, J.; BOERNER, B. C.; MALFATTI, T.; BRISA, E.; DOERL, J.; NOGUEIRA, I.; LEÃO, K. E.; LEÃO, R. N. Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT. Exp Neurol., [s. l.], v. 326, p. 113175, jan. 2020. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/jspui/handle/123456789/28384 |
dc.identifier.doi.none.fl_str_mv |
10.1016/j.expneurol.2020.113175 |
identifier_str_mv |
WINNE, J.; BOERNER, B. C.; MALFATTI, T.; BRISA, E.; DOERL, J.; NOGUEIRA, I.; LEÃO, K. E.; LEÃO, R. N. Anxiety-like behavior induced by salicylate depends on age and can be prevented by a single dose of 5-MeO-DMT. Exp Neurol., [s. l.], v. 326, p. 113175, jan. 2020. 10.1016/j.expneurol.2020.113175 |
url |
https://repositorio.ufrn.br/jspui/handle/123456789/28384 |
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eng |
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eng |
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