Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial
Autor(a) principal: | |
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Data de Publicação: | 2013 |
Outros Autores: | , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/55879 https://doi.org/10.1017/S0007114512005442 |
Resumo: | Evidence supports an important contribution of abdominal obesity and inflammation to the development of insulin resistance (IR) and CVD. Weight loss in obese individuals can reduce inflammation and, consequently, IR, but the role of training remains unclear. The aim of this study was to evaluate the effects of body weight reduction with and without exercise over abdominal fat tissue (primary outcome) and IR. In this randomised clinical trial, forty-eight obese individuals (age 31·8 (SD 6·0) years, BMI 34·8 (SD 2·7) kg/m2 ) were randomised to either a diet-only group (DI) or a diet and exercise group (DI þ EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analysed: biochemical parameters such as glycaemia and insulin for the determination of homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP) and abdominal computed tomography for the determination of visceral and subcutaneous adipose tissue. A total of thirteen individuals dropped out before completing the weight-loss intervention and did not repeat the tests. In both the DI (n 18) and DI þ EXE (n 17) groups, we observed significant and similar decreases of visceral adipose tissue (difference between means: 7·9 (95 % CI 29·5, 25·2) cm2 , P¼0·36), hs-CRP (difference between means: 20·06 (95 % CI 20·19, 0·03) mg/l, P¼0·39) and HOMA (difference between means: 20·04 (95 % CI 20·17, 0·08), P¼0·53). In the present study, 5 % weight loss reduced abdominal fat and IR in obese individuals and exercise did not add to the effect of weight loss on the outcome variables |
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Fayh, Ana Paula TrussardiLopes, André LuizFernandes, Pablo RoberOliveira, Alvaro ReischakFriedman, Rogério2023-12-13T17:52:03Z2023-12-13T17:52:03Z2013-01FAYH, Ana Paula Trussardi; LOPES, André Luiz; FERNANDES, Pablo Rober; OLIVEIRA, Alvaro Reischak; FRIEDMAN, Rogério. Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial. British Journal of Nutrition, v. 110, p. 486-492, 10 jan. 2013. DOI: 10.1017/S0007114512005442. Disponível em: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-weight-loss-with-or-without-exercise-on-abdominal-fat-and-insulin-resistance-in-obese-individuals-a-randomised-clinical-trial/0841E9E32511D13949EA62CD260564E8. Acesso em: 7 dez. 2023.https://repositorio.ufrn.br/handle/123456789/55879https://doi.org/10.1017/S0007114512005442British Journal of NutritionAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessWeight lossDietPhysical trainingObeseInsulin resistanceImpact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trialinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleEvidence supports an important contribution of abdominal obesity and inflammation to the development of insulin resistance (IR) and CVD. Weight loss in obese individuals can reduce inflammation and, consequently, IR, but the role of training remains unclear. The aim of this study was to evaluate the effects of body weight reduction with and without exercise over abdominal fat tissue (primary outcome) and IR. In this randomised clinical trial, forty-eight obese individuals (age 31·8 (SD 6·0) years, BMI 34·8 (SD 2·7) kg/m2 ) were randomised to either a diet-only group (DI) or a diet and exercise group (DI þ EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analysed: biochemical parameters such as glycaemia and insulin for the determination of homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP) and abdominal computed tomography for the determination of visceral and subcutaneous adipose tissue. A total of thirteen individuals dropped out before completing the weight-loss intervention and did not repeat the tests. In both the DI (n 18) and DI þ EXE (n 17) groups, we observed significant and similar decreases of visceral adipose tissue (difference between means: 7·9 (95 % CI 29·5, 25·2) cm2 , P¼0·36), hs-CRP (difference between means: 20·06 (95 % CI 20·19, 0·03) mg/l, P¼0·39) and HOMA (difference between means: 20·04 (95 % CI 20·17, 0·08), P¼0·53). In the present study, 5 % weight loss reduced abdominal fat and IR in obese individuals and exercise did not add to the effect of weight loss on the outcome variablesengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALImpactWeight_Fayh_2013.pdfImpactWeight_Fayh_2013.pdfapplication/pdf170802https://repositorio.ufrn.br/bitstream/123456789/55879/1/ImpactWeight_Fayh_2013.pdf0c06dc99c7a3f53d15e38a695a4b64f7MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/55879/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/55879/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53123456789/558792023-12-13 14:52:03.727oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-12-13T17:52:03Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
title |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
spellingShingle |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial Fayh, Ana Paula Trussardi Weight loss Diet Physical training Obese Insulin resistance |
title_short |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
title_full |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
title_fullStr |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
title_full_unstemmed |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
title_sort |
Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial |
author |
Fayh, Ana Paula Trussardi |
author_facet |
Fayh, Ana Paula Trussardi Lopes, André Luiz Fernandes, Pablo Rober Oliveira, Alvaro Reischak Friedman, Rogério |
author_role |
author |
author2 |
Lopes, André Luiz Fernandes, Pablo Rober Oliveira, Alvaro Reischak Friedman, Rogério |
author2_role |
author author author author |
dc.contributor.author.fl_str_mv |
Fayh, Ana Paula Trussardi Lopes, André Luiz Fernandes, Pablo Rober Oliveira, Alvaro Reischak Friedman, Rogério |
dc.subject.por.fl_str_mv |
Weight loss Diet Physical training Obese Insulin resistance |
topic |
Weight loss Diet Physical training Obese Insulin resistance |
description |
Evidence supports an important contribution of abdominal obesity and inflammation to the development of insulin resistance (IR) and CVD. Weight loss in obese individuals can reduce inflammation and, consequently, IR, but the role of training remains unclear. The aim of this study was to evaluate the effects of body weight reduction with and without exercise over abdominal fat tissue (primary outcome) and IR. In this randomised clinical trial, forty-eight obese individuals (age 31·8 (SD 6·0) years, BMI 34·8 (SD 2·7) kg/m2 ) were randomised to either a diet-only group (DI) or a diet and exercise group (DI þ EXE). Treatment was maintained until 5 % of the initial body weight was lost. At baseline and upon completion, the following parameters were analysed: biochemical parameters such as glycaemia and insulin for the determination of homeostasis model assessment of insulin resistance (HOMA-IR), high-sensitivity C-reactive protein (hs-CRP) and abdominal computed tomography for the determination of visceral and subcutaneous adipose tissue. A total of thirteen individuals dropped out before completing the weight-loss intervention and did not repeat the tests. In both the DI (n 18) and DI þ EXE (n 17) groups, we observed significant and similar decreases of visceral adipose tissue (difference between means: 7·9 (95 % CI 29·5, 25·2) cm2 , P¼0·36), hs-CRP (difference between means: 20·06 (95 % CI 20·19, 0·03) mg/l, P¼0·39) and HOMA (difference between means: 20·04 (95 % CI 20·17, 0·08), P¼0·53). In the present study, 5 % weight loss reduced abdominal fat and IR in obese individuals and exercise did not add to the effect of weight loss on the outcome variables |
publishDate |
2013 |
dc.date.issued.fl_str_mv |
2013-01 |
dc.date.accessioned.fl_str_mv |
2023-12-13T17:52:03Z |
dc.date.available.fl_str_mv |
2023-12-13T17:52:03Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FAYH, Ana Paula Trussardi; LOPES, André Luiz; FERNANDES, Pablo Rober; OLIVEIRA, Alvaro Reischak; FRIEDMAN, Rogério. Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial. British Journal of Nutrition, v. 110, p. 486-492, 10 jan. 2013. DOI: 10.1017/S0007114512005442. Disponível em: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-weight-loss-with-or-without-exercise-on-abdominal-fat-and-insulin-resistance-in-obese-individuals-a-randomised-clinical-trial/0841E9E32511D13949EA62CD260564E8. Acesso em: 7 dez. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/55879 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.1017/S0007114512005442 |
identifier_str_mv |
FAYH, Ana Paula Trussardi; LOPES, André Luiz; FERNANDES, Pablo Rober; OLIVEIRA, Alvaro Reischak; FRIEDMAN, Rogério. Impact of weight loss with or without exercise on abdominal fat and insulin resistance in obese individuals: a randomized clinical trial. British Journal of Nutrition, v. 110, p. 486-492, 10 jan. 2013. DOI: 10.1017/S0007114512005442. Disponível em: https://www.cambridge.org/core/journals/british-journal-of-nutrition/article/impact-of-weight-loss-with-or-without-exercise-on-abdominal-fat-and-insulin-resistance-in-obese-individuals-a-randomised-clinical-trial/0841E9E32511D13949EA62CD260564E8. Acesso em: 7 dez. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/55879 https://doi.org/10.1017/S0007114512005442 |
dc.language.iso.fl_str_mv |
eng |
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eng |
dc.rights.driver.fl_str_mv |
Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
dc.publisher.none.fl_str_mv |
British Journal of Nutrition |
publisher.none.fl_str_mv |
British Journal of Nutrition |
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Universidade Federal do Rio Grande do Norte (UFRN) |
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UFRN |
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UFRN |
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Repositório Institucional da UFRN |
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