Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio
Autor(a) principal: | |
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Data de Publicação: | 2015 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
DOI: | https://doi.org/10.4187/respcare.03367 |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/54254 https://doi.org/10.4187/respcare.03367 |
Resumo: | Neuromuscular diseases (NMDs) lead to different weakness patterns, and most patients with NMDs develop respiratory failure. Inspiratory and expiratory muscle strength can be measured by maximum static inspiratory pressure (PImax) and maximum static expiratory pressure (PEmax), and the relationship between them has not been well described in healthy subjects and subjects with NMDs. Our aim was to assess expiratory/inspiratory muscle strength in NMDs and healthy subjects and calculate PEmax/PImax ratio for these groups. METHODS: Seventy (35 males) subjects with NMDs (amyotrophic lateral sclerosis, myasthenia gravis, and myotonic dystrophy), and 93 (47 males) healthy individuals 20 – 80 y of age were evaluated for anthropometry, pulmonary function, PImax, and PEmax, respectively. RESULTS: Healthy individuals showed greater values for PImax and PEmax when compared with subjects with NMDs. PEmax/PImax ratio for healthy subjects was 1.31 0.26, and PEmax%/PImax% was 1.04 0.05; for subjects with NMDs, PEmax/PImax ratio was 1.45 0.65, and PEmax%/PImax% ratio was 1.42 0.67. We found that PEmax%/PImax% for myotonic dystrophy was 0.93 0.24, for myasthenia gravis 1.94 0.6, and for amyotrophic lateral sclerosis 1.33 0.62 when we analyzed them separately. All healthy individuals showed higher PEmax compared with PImax. For subjects with NMDs, the impairment of PEmax and PImax is different among the 3 pathologies studied (P < .001). CONCLUSIONS: Healthy individuals and subjects with NMDs showed higher PEmax in comparison to PImax regarding the PEmax/PImax ratio. Based on the ratio, it is possible to state that NMDs show different patterns of respiratory muscle strength loss. PEmax/PImax ratio is a useful parameter to assess the impairment of respiratory muscles in a patient and to customize rehabilitation and treatment. |
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Dourado Junior, Mário Emílio TeixeiraFregonezi, GuilhermeAzevedo, Ingrid GResqueti, Vanessa RAndrade, Arme`le D DeGualdi, Lucien PAliverti, AndreaParreira, Veronica Fhttps://orcid.org/0000-0002-9462-22942023-07-28T12:54:35Z2023-07-28T12:54:35Z2015FREGONEZI, Guilherme; AZEVEDO, Ingrid G; RESQUETI, Vanessa R; ANDRADE, Armèle D de; GUALDI, Lucien P; ALIVERTI, Andrea; DOURADO JUNIOR, Mário Emílio Teixeira; PARREIRA, Verônica F. Muscle Impairment in Neuromuscular Disease Using an Expiratory/Inspiratory Pressure Ratio. Respiratory Care, [S.L.], v. 60, n. 4, p. 533-539, 13 jan. 2015. Daedalus Enterprises. http://dx.doi.org/10.4187/respcare.03367. Disponível em: https://rc.rcjournal.com/content/60/4/533. Acesso em: 21 jul. 2023.https://repositorio.ufrn.br/handle/123456789/54254https://doi.org/10.4187/respcare.03367Respiratory Carerespiratory muscle strengthrespiratory muscle imbalanceneuromuscular diseasesrespiratory therapyMuscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratioinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleNeuromuscular diseases (NMDs) lead to different weakness patterns, and most patients with NMDs develop respiratory failure. Inspiratory and expiratory muscle strength can be measured by maximum static inspiratory pressure (PImax) and maximum static expiratory pressure (PEmax), and the relationship between them has not been well described in healthy subjects and subjects with NMDs. Our aim was to assess expiratory/inspiratory muscle strength in NMDs and healthy subjects and calculate PEmax/PImax ratio for these groups. METHODS: Seventy (35 males) subjects with NMDs (amyotrophic lateral sclerosis, myasthenia gravis, and myotonic dystrophy), and 93 (47 males) healthy individuals 20 – 80 y of age were evaluated for anthropometry, pulmonary function, PImax, and PEmax, respectively. RESULTS: Healthy individuals showed greater values for PImax and PEmax when compared with subjects with NMDs. PEmax/PImax ratio for healthy subjects was 1.31 0.26, and PEmax%/PImax% was 1.04 0.05; for subjects with NMDs, PEmax/PImax ratio was 1.45 0.65, and PEmax%/PImax% ratio was 1.42 0.67. We found that PEmax%/PImax% for myotonic dystrophy was 0.93 0.24, for myasthenia gravis 1.94 0.6, and for amyotrophic lateral sclerosis 1.33 0.62 when we analyzed them separately. All healthy individuals showed higher PEmax compared with PImax. For subjects with NMDs, the impairment of PEmax and PImax is different among the 3 pathologies studied (P < .001). CONCLUSIONS: Healthy individuals and subjects with NMDs showed higher PEmax in comparison to PImax regarding the PEmax/PImax ratio. Based on the ratio, it is possible to state that NMDs show different patterns of respiratory muscle strength loss. PEmax/PImax ratio is a useful parameter to assess the impairment of respiratory muscles in a patient and to customize rehabilitation and treatment.engreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNinfo:eu-repo/semantics/openAccessORIGINALMuscleImpairmentNeuromuscular_DouradoJr_2015.pdfMuscleImpairmentNeuromuscular_DouradoJr_2015.pdfapplication/pdf654587https://repositorio.ufrn.br/bitstream/123456789/54254/1/MuscleImpairmentNeuromuscular_DouradoJr_2015.pdfcccbf604e026aa82dcb62fddda85615aMD51LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/54254/2/license.txte9597aa2854d128fd968be5edc8a28d9MD52123456789/542542023-07-28 09:54:35.807oai:https://repositorio.ufrn.br:123456789/54254Tk9OLUVYQ0xVU0lWRSBESVNUUklCVVRJT04gTElDRU5TRQoKCkJ5IHNpZ25pbmcgYW5kIGRlbGl2ZXJpbmcgdGhpcyBsaWNlbnNlLCBNci4gKGF1dGhvciBvciBjb3B5cmlnaHQgaG9sZGVyKToKCgphKSBHcmFudHMgdGhlIFVuaXZlcnNpZGFkZSBGZWRlcmFsIFJpbyBHcmFuZGUgZG8gTm9ydGUgdGhlIG5vbi1leGNsdXNpdmUgcmlnaHQgb2YKcmVwcm9kdWNlLCBjb252ZXJ0IChhcyBkZWZpbmVkIGJlbG93KSwgY29tbXVuaWNhdGUgYW5kIC8gb3IKZGlzdHJpYnV0ZSB0aGUgZGVsaXZlcmVkIGRvY3VtZW50IChpbmNsdWRpbmcgYWJzdHJhY3QgLyBhYnN0cmFjdCkgaW4KZGlnaXRhbCBvciBwcmludGVkIGZvcm1hdCBhbmQgaW4gYW55IG1lZGl1bS4KCmIpIERlY2xhcmVzIHRoYXQgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBpdHMgb3JpZ2luYWwgd29yaywgYW5kIHRoYXQKeW91IGhhdmUgdGhlIHJpZ2h0IHRvIGdyYW50IHRoZSByaWdodHMgY29udGFpbmVkIGluIHRoaXMgbGljZW5zZS4gRGVjbGFyZXMKdGhhdCB0aGUgZGVsaXZlcnkgb2YgdGhlIGRvY3VtZW50IGRvZXMgbm90IGluZnJpbmdlLCBhcyBmYXIgYXMgaXQgaXMKdGhlIHJpZ2h0cyBvZiBhbnkgb3RoZXIgcGVyc29uIG9yIGVudGl0eS4KCmMpIElmIHRoZSBkb2N1bWVudCBkZWxpdmVyZWQgY29udGFpbnMgbWF0ZXJpYWwgd2hpY2ggZG9lcyBub3QKcmlnaHRzLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBvYnRhaW5lZCBhdXRob3JpemF0aW9uIGZyb20gdGhlIGhvbGRlciBvZiB0aGUKY29weXJpZ2h0IHRvIGdyYW50IHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlIHRoZSByaWdodHMgcmVxdWlyZWQgYnkgdGhpcyBsaWNlbnNlLCBhbmQgdGhhdCB0aGlzIG1hdGVyaWFsIHdob3NlIHJpZ2h0cyBhcmUgb2YKdGhpcmQgcGFydGllcyBpcyBjbGVhcmx5IGlkZW50aWZpZWQgYW5kIHJlY29nbml6ZWQgaW4gdGhlIHRleHQgb3IKY29udGVudCBvZiB0aGUgZG9jdW1lbnQgZGVsaXZlcmVkLgoKSWYgdGhlIGRvY3VtZW50IHN1Ym1pdHRlZCBpcyBiYXNlZCBvbiBmdW5kZWQgb3Igc3VwcG9ydGVkIHdvcmsKYnkgYW5vdGhlciBpbnN0aXR1dGlvbiBvdGhlciB0aGFuIHRoZSBVbml2ZXJzaWRhZGUgRmVkZXJhbCBkbyBSaW8gR3JhbmRlIGRvIE5vcnRlLCBkZWNsYXJlcyB0aGF0IGl0IGhhcyBmdWxmaWxsZWQgYW55IG9ibGlnYXRpb25zIHJlcXVpcmVkIGJ5IHRoZSByZXNwZWN0aXZlIGFncmVlbWVudCBvciBhZ3JlZW1lbnQuCgpUaGUgVW5pdmVyc2lkYWRlIEZlZGVyYWwgZG8gUmlvIEdyYW5kZSBkbyBOb3J0ZSB3aWxsIGNsZWFybHkgaWRlbnRpZnkgaXRzIG5hbWUgKHMpIGFzIHRoZSBhdXRob3IgKHMpIG9yIGhvbGRlciAocykgb2YgdGhlIGRvY3VtZW50J3MgcmlnaHRzCmRlbGl2ZXJlZCwgYW5kIHdpbGwgbm90IG1ha2UgYW55IGNoYW5nZXMsIG90aGVyIHRoYW4gdGhvc2UgcGVybWl0dGVkIGJ5CnRoaXMgbGljZW5zZQo=Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2023-07-28T12:54:35Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
title |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
spellingShingle |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio Dourado Junior, Mário Emílio Teixeira respiratory muscle strength respiratory muscle imbalance neuromuscular diseases respiratory therapy |
title_short |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
title_full |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
title_fullStr |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
title_full_unstemmed |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
title_sort |
Muscle impairment in neuromuscular disease using an expiratory/inspiratory pressure ratio |
author |
Dourado Junior, Mário Emílio Teixeira |
author_facet |
Dourado Junior, Mário Emílio Teixeira Fregonezi, Guilherme Azevedo, Ingrid G Resqueti, Vanessa R Andrade, Arme`le D De Gualdi, Lucien P Aliverti, Andrea Parreira, Veronica F |
author_role |
author |
author2 |
Fregonezi, Guilherme Azevedo, Ingrid G Resqueti, Vanessa R Andrade, Arme`le D De Gualdi, Lucien P Aliverti, Andrea Parreira, Veronica F |
author2_role |
author author author author author author author |
dc.contributor.authorID.pt_BR.fl_str_mv |
https://orcid.org/0000-0002-9462-2294 |
dc.contributor.author.fl_str_mv |
Dourado Junior, Mário Emílio Teixeira Fregonezi, Guilherme Azevedo, Ingrid G Resqueti, Vanessa R Andrade, Arme`le D De Gualdi, Lucien P Aliverti, Andrea Parreira, Veronica F |
dc.subject.por.fl_str_mv |
respiratory muscle strength respiratory muscle imbalance neuromuscular diseases respiratory therapy |
topic |
respiratory muscle strength respiratory muscle imbalance neuromuscular diseases respiratory therapy |
description |
Neuromuscular diseases (NMDs) lead to different weakness patterns, and most patients with NMDs develop respiratory failure. Inspiratory and expiratory muscle strength can be measured by maximum static inspiratory pressure (PImax) and maximum static expiratory pressure (PEmax), and the relationship between them has not been well described in healthy subjects and subjects with NMDs. Our aim was to assess expiratory/inspiratory muscle strength in NMDs and healthy subjects and calculate PEmax/PImax ratio for these groups. METHODS: Seventy (35 males) subjects with NMDs (amyotrophic lateral sclerosis, myasthenia gravis, and myotonic dystrophy), and 93 (47 males) healthy individuals 20 – 80 y of age were evaluated for anthropometry, pulmonary function, PImax, and PEmax, respectively. RESULTS: Healthy individuals showed greater values for PImax and PEmax when compared with subjects with NMDs. PEmax/PImax ratio for healthy subjects was 1.31 0.26, and PEmax%/PImax% was 1.04 0.05; for subjects with NMDs, PEmax/PImax ratio was 1.45 0.65, and PEmax%/PImax% ratio was 1.42 0.67. We found that PEmax%/PImax% for myotonic dystrophy was 0.93 0.24, for myasthenia gravis 1.94 0.6, and for amyotrophic lateral sclerosis 1.33 0.62 when we analyzed them separately. All healthy individuals showed higher PEmax compared with PImax. For subjects with NMDs, the impairment of PEmax and PImax is different among the 3 pathologies studied (P < .001). CONCLUSIONS: Healthy individuals and subjects with NMDs showed higher PEmax in comparison to PImax regarding the PEmax/PImax ratio. Based on the ratio, it is possible to state that NMDs show different patterns of respiratory muscle strength loss. PEmax/PImax ratio is a useful parameter to assess the impairment of respiratory muscles in a patient and to customize rehabilitation and treatment. |
publishDate |
2015 |
dc.date.issued.fl_str_mv |
2015 |
dc.date.accessioned.fl_str_mv |
2023-07-28T12:54:35Z |
dc.date.available.fl_str_mv |
2023-07-28T12:54:35Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
FREGONEZI, Guilherme; AZEVEDO, Ingrid G; RESQUETI, Vanessa R; ANDRADE, Armèle D de; GUALDI, Lucien P; ALIVERTI, Andrea; DOURADO JUNIOR, Mário Emílio Teixeira; PARREIRA, Verônica F. Muscle Impairment in Neuromuscular Disease Using an Expiratory/Inspiratory Pressure Ratio. Respiratory Care, [S.L.], v. 60, n. 4, p. 533-539, 13 jan. 2015. Daedalus Enterprises. http://dx.doi.org/10.4187/respcare.03367. Disponível em: https://rc.rcjournal.com/content/60/4/533. Acesso em: 21 jul. 2023. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/54254 |
dc.identifier.doi.none.fl_str_mv |
https://doi.org/10.4187/respcare.03367 |
identifier_str_mv |
FREGONEZI, Guilherme; AZEVEDO, Ingrid G; RESQUETI, Vanessa R; ANDRADE, Armèle D de; GUALDI, Lucien P; ALIVERTI, Andrea; DOURADO JUNIOR, Mário Emílio Teixeira; PARREIRA, Verônica F. Muscle Impairment in Neuromuscular Disease Using an Expiratory/Inspiratory Pressure Ratio. Respiratory Care, [S.L.], v. 60, n. 4, p. 533-539, 13 jan. 2015. Daedalus Enterprises. http://dx.doi.org/10.4187/respcare.03367. Disponível em: https://rc.rcjournal.com/content/60/4/533. Acesso em: 21 jul. 2023. |
url |
https://repositorio.ufrn.br/handle/123456789/54254 https://doi.org/10.4187/respcare.03367 |
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eng |
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eng |
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info:eu-repo/semantics/openAccess |
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openAccess |
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Respiratory Care |
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Respiratory Care |
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