Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation
Autor(a) principal: | |
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Data de Publicação: | 2020 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UFRN |
Texto Completo: | https://repositorio.ufrn.br/handle/123456789/31189 |
Resumo: | The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent |
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Oliveira, Leticia Castelo Branco PerobaQueiroz, Moacir FernandesFidelis, Gabriel PereiraMelo, Karoline Rachel TeodosioCâmara, Rafael Barros Gomes daAlves, Monique Gabriela das Chagas FaustinoCosta, Leandro SilvaTeixeira, Dárlio Inácio AlvesMelo-Silveira, Raniere FagundesRocha, Hugo Alexandre de Oliveira2021-01-05T16:53:18Z2021-01-05T16:53:18Z2020-04-28OLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/25/9/2055/htm. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/molecules25092055.1420-3049 (online)https://repositorio.ufrn.br/handle/123456789/3118910.3390/molecules25092055MDPIAttribution 3.0 Brazilhttp://creativecommons.org/licenses/by/3.0/br/info:eu-repo/semantics/openAccessSulfated galactanRed seaweedAntioxidantCalcium oxalate dihydrate crystalsUrolithiasisAntioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formationinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleThe genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agentengreponame:Repositório Institucional da UFRNinstname:Universidade Federal do Rio Grande do Norte (UFRN)instacron:UFRNORIGINALAntioxidantSulfatedPolysaccharide_Camara_2020.pdfAntioxidantSulfatedPolysaccharide_Camara_2020.pdfapplication/pdf1831097https://repositorio.ufrn.br/bitstream/123456789/31189/1/AntioxidantSulfatedPolysaccharide_Camara_2020.pdfa70e196260d96a65857ffa2e2f698f34MD51CC-LICENSElicense_rdflicense_rdfapplication/rdf+xml; charset=utf-8914https://repositorio.ufrn.br/bitstream/123456789/31189/2/license_rdf4d2950bda3d176f570a9f8b328dfbbefMD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81484https://repositorio.ufrn.br/bitstream/123456789/31189/3/license.txte9597aa2854d128fd968be5edc8a28d9MD53TEXTAntioxidantSulfatedPolysaccharide_Câmara_2020.pdf.txtAntioxidantSulfatedPolysaccharide_Câmara_2020.pdf.txtExtracted texttext/plain60598https://repositorio.ufrn.br/bitstream/123456789/31189/4/AntioxidantSulfatedPolysaccharide_C%c3%a2mara_2020.pdf.txtdca6785df395e8a605ab15403d2c9f76MD54THUMBNAILAntioxidantSulfatedPolysaccharide_Câmara_2020.pdf.jpgAntioxidantSulfatedPolysaccharide_Câmara_2020.pdf.jpgGenerated Thumbnailimage/jpeg1636https://repositorio.ufrn.br/bitstream/123456789/31189/5/AntioxidantSulfatedPolysaccharide_C%c3%a2mara_2020.pdf.jpg36e2b6903f3e447badd756482c09f776MD55123456789/311892021-11-09 16:20:50.808oai:https://repositorio.ufrn.br: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Repositório de PublicaçõesPUBhttp://repositorio.ufrn.br/oai/opendoar:2021-11-09T19:20:50Repositório Institucional da UFRN - Universidade Federal do Rio Grande do Norte (UFRN)false |
dc.title.pt_BR.fl_str_mv |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
title |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
spellingShingle |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation Oliveira, Leticia Castelo Branco Peroba Sulfated galactan Red seaweed Antioxidant Calcium oxalate dihydrate crystals Urolithiasis |
title_short |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
title_full |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
title_fullStr |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
title_full_unstemmed |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
title_sort |
Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation |
author |
Oliveira, Leticia Castelo Branco Peroba |
author_facet |
Oliveira, Leticia Castelo Branco Peroba Queiroz, Moacir Fernandes Fidelis, Gabriel Pereira Melo, Karoline Rachel Teodosio Câmara, Rafael Barros Gomes da Alves, Monique Gabriela das Chagas Faustino Costa, Leandro Silva Teixeira, Dárlio Inácio Alves Melo-Silveira, Raniere Fagundes Rocha, Hugo Alexandre de Oliveira |
author_role |
author |
author2 |
Queiroz, Moacir Fernandes Fidelis, Gabriel Pereira Melo, Karoline Rachel Teodosio Câmara, Rafael Barros Gomes da Alves, Monique Gabriela das Chagas Faustino Costa, Leandro Silva Teixeira, Dárlio Inácio Alves Melo-Silveira, Raniere Fagundes Rocha, Hugo Alexandre de Oliveira |
author2_role |
author author author author author author author author author |
dc.contributor.author.fl_str_mv |
Oliveira, Leticia Castelo Branco Peroba Queiroz, Moacir Fernandes Fidelis, Gabriel Pereira Melo, Karoline Rachel Teodosio Câmara, Rafael Barros Gomes da Alves, Monique Gabriela das Chagas Faustino Costa, Leandro Silva Teixeira, Dárlio Inácio Alves Melo-Silveira, Raniere Fagundes Rocha, Hugo Alexandre de Oliveira |
dc.subject.por.fl_str_mv |
Sulfated galactan Red seaweed Antioxidant Calcium oxalate dihydrate crystals Urolithiasis |
topic |
Sulfated galactan Red seaweed Antioxidant Calcium oxalate dihydrate crystals Urolithiasis |
description |
The genus Gracilaria synthesizes sulfated polysaccharides (SPs). Many of these SPs, including those synthesized by the edible seaweed Gracilaria birdiae, have not yet been adequately investigated for their use as potential pharmaceutical compounds. Previous studies have demonstrated the immunomodulatory effects of sulfated galactans from G. birdiae. In this study, a galactan (GB) was extracted from G. birdiae and evaluated by cell proliferation and antioxidant tests. GB showed no radical hydroxyl (OH) and superoxide (O2−) scavenging ability. However, GB was able to donate electrons in two further different assays and presented iron- and copper-chelating activity. Urolithiasis affects approximately 10% of the world’s population and is strongly associated with calcium oxalate (CaOx) crystals. No efficient compound is currently available for the treatment of this disease. GB appeared to interact with and stabilize calcium oxalate dihydrate crystals, leading to the modification of their morphology, size, and surface charge. These crystals then acquired the same characteristics as those found in healthy individuals. In addition, GB showed no cytotoxic effect against human kidney cells (HEK-293). Taken together, our current findings highlight the potential application of GB as an antiurolithic agent |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-04-28 |
dc.date.accessioned.fl_str_mv |
2021-01-05T16:53:18Z |
dc.date.available.fl_str_mv |
2021-01-05T16:53:18Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/25/9/2055/htm. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/molecules25092055. |
dc.identifier.uri.fl_str_mv |
https://repositorio.ufrn.br/handle/123456789/31189 |
dc.identifier.issn.none.fl_str_mv |
1420-3049 (online) |
dc.identifier.doi.none.fl_str_mv |
10.3390/molecules25092055 |
identifier_str_mv |
OLIVEIRA, Leticia Castelo Branco Peroba; QUEIROZ, Moacir Fernandes; FIDELIS, Gabriel Pereira; MELO, Karoline Rachel Teodosio; CÂMARA, Rafael Barros Gomes; ALVES, Monique Gabriela Chagas Faustino; COSTA, Leandro Silva; TEIXEIRA, Dárlio Inácio Alves; MELO-SILVEIRA, Raniere Fagundes; ROCHA, Hugo Alexandre Oliveira. Antioxidant sulfated polysaccharide from edible red seaweed Gracilaria birdiae is an inhibitor of calcium oxalate crystal formation. Molecules, [s. l.], v. 25, n. 9, p. 2055-2069, 28 abr. 2020. MDPI AG. Disponível em: https://www.mdpi.com/1420-3049/25/9/2055/htm. Acesso em: 03 ago. 2020. http://dx.doi.org/10.3390/molecules25092055. 1420-3049 (online) 10.3390/molecules25092055 |
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https://repositorio.ufrn.br/handle/123456789/31189 |
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eng |
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eng |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ info:eu-repo/semantics/openAccess |
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Attribution 3.0 Brazil http://creativecommons.org/licenses/by/3.0/br/ |
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openAccess |
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MDPI |
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MDPI |
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