Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/10703 |
Resumo: | Retinyl, derived from vitamin A, is a cosmetic active substance widely used in antiaging skin 52 treatment. Thus, the objective of this work was to obtain lipid nanoparticles (NL) containing retinol 53 acetate for cosmetic use. NL were obtained by the solvent diffusion method in the aqueous phase, 54 using only beeswax as a lipid matrix (NLS) or incorporating squalene as liquid lipid (CLN). The 55 particle size, polydispersity index, zeta potential and encapsulation efficiency of the samples were 56 determined. The in vitro release study was also performed using Franz type diffusion cells. As 57 results, all samples had a nanometric size between 143 and 774 nm, maximum IPD of 0.340 and 58 elevated PZ. The EE obtained was 99.95% and 100% for the NL obtained. The NL were able to 59 efficiently incorporate the retinol acetate. Carriers containing squalene in the lipid matrix presented 60 better results, with smaller size and more uniform size distribution, besides a PZ above 30 | mV. 61 These carriers had a sustained release profile during the study period. Thus, we conclude that under 62 the conditions employed and evaluated, CLNs have been shown to be more promising formulations 63 for the delivery of the active than NLS. |
id |
UFS-2_48d505250ea3f82bc9bf8931406878ae |
---|---|
oai_identifier_str |
oai:ufs.br:riufs/10703 |
network_acronym_str |
UFS-2 |
network_name_str |
Repositório Institucional da UFS |
repository_id_str |
|
spelling |
Oliveira Neta, Paulinha Marques deLira, Ana Amélia Moreira2019-03-20T11:48:04Z2019-03-20T11:48:04Z2017-09-11Oliveira Neta, Paulinha Marques de. Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017http://ri.ufs.br/jspui/handle/riufs/10703Retinyl, derived from vitamin A, is a cosmetic active substance widely used in antiaging skin 52 treatment. Thus, the objective of this work was to obtain lipid nanoparticles (NL) containing retinol 53 acetate for cosmetic use. NL were obtained by the solvent diffusion method in the aqueous phase, 54 using only beeswax as a lipid matrix (NLS) or incorporating squalene as liquid lipid (CLN). The 55 particle size, polydispersity index, zeta potential and encapsulation efficiency of the samples were 56 determined. The in vitro release study was also performed using Franz type diffusion cells. As 57 results, all samples had a nanometric size between 143 and 774 nm, maximum IPD of 0.340 and 58 elevated PZ. The EE obtained was 99.95% and 100% for the NL obtained. The NL were able to 59 efficiently incorporate the retinol acetate. Carriers containing squalene in the lipid matrix presented 60 better results, with smaller size and more uniform size distribution, besides a PZ above 30 | mV. 61 These carriers had a sustained release profile during the study period. Thus, we conclude that under 62 the conditions employed and evaluated, CLNs have been shown to be more promising formulations 63 for the delivery of the active than NLS.O retinol, derivado da vitamina A, é um ativo cosmético muito usado em tratamento 28 antienvelhecimento da pele. Desta forma, o objetivo deste trabalho foi obter nanopartículas lipídicas 29 (NL) contendo acetato de retinol para uso cosmético. As NL foram obtidas através do método de 30 difusão de solvente em fase aquosa, utilizando apenas cera de abelha como matriz lipídica (NLS) ou 31 incorporar esqualeno como lipídio líquido (CLN). O tamanho das partículas, índice de 32 polidispersividade , potencial zeta e eficiência de encapsulação das amostras foram determinados. O 33 estudo de liberação in vitro foi também realizado utilizando células de difusão tipo Franz. Como 34 resultados, todas as amostras apresentaram tamanho nanométrico entre 143 e 774 nm, IPD máximo 35 de 0,340 e PZ elevado. A EE obtida foi de 99,95% e 100% para as NL obtidas.As NL foram 36 capazes de incorporar eficientemente o acetato de retinol. Carreadores contendo esqualeno na 37 matriz lipídica apresentaram melhores resultados, com tamanho menor e distribuição de tamanho 38 mais uniforme, além de um PZ acima de |30| mV. Estes carreadores apresentaram perfil de 39 liberação sustentada durante o período estudado. Assim, concluímos que nas condições empregadas 40 e avaliadas, os CLN mostraram ser formulações mais promissoras para a veiculação do ativo que as 41 NLS.São Cristóvão, SEporFarmáciaEnsino de farmáciaLipídicos NnnoestruturadosCLNNLSAcetato de retinolNanostructured Lipid CarriersSolid Lipid NanoparticlesRetinol acetateCIENCIAS DA SAUDE::FARMACIAObtenção e caracterização de nanopartículas de cera de abelha contendo retinolinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal de SergipeDFA - Departamento de Farmácia – São Cristóvão - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTEXTPaulina_Marques_Oliveira_Neta.pdf.txtPaulina_Marques_Oliveira_Neta.pdf.txtExtracted texttext/plain25096https://ri.ufs.br/jspui/bitstream/riufs/10703/3/Paulina_Marques_Oliveira_Neta.pdf.txtfd42eb7c4eb6f84bd1cda65c51eb8e23MD53THUMBNAILPaulina_Marques_Oliveira_Neta.pdf.jpgPaulina_Marques_Oliveira_Neta.pdf.jpgGenerated Thumbnailimage/jpeg1178https://ri.ufs.br/jspui/bitstream/riufs/10703/4/Paulina_Marques_Oliveira_Neta.pdf.jpg723e7d416311b6014ee4bf093e5f6226MD54ORIGINALPaulina_Marques_Oliveira_Neta.pdfPaulina_Marques_Oliveira_Neta.pdfapplication/pdf670705https://ri.ufs.br/jspui/bitstream/riufs/10703/2/Paulina_Marques_Oliveira_Neta.pdf53afefadcf0f9c4f83e3ffd24ca35501MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/10703/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51riufs/107032019-03-20 08:49:20.194oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2019-03-20T11:49:20Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
title |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
spellingShingle |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol Oliveira Neta, Paulinha Marques de Farmácia Ensino de farmácia Lipídicos Nnnoestruturados CLN NLS Acetato de retinol Nanostructured Lipid Carriers Solid Lipid Nanoparticles Retinol acetate CIENCIAS DA SAUDE::FARMACIA |
title_short |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
title_full |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
title_fullStr |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
title_full_unstemmed |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
title_sort |
Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol |
author |
Oliveira Neta, Paulinha Marques de |
author_facet |
Oliveira Neta, Paulinha Marques de |
author_role |
author |
dc.contributor.author.fl_str_mv |
Oliveira Neta, Paulinha Marques de |
dc.contributor.advisor1.fl_str_mv |
Lira, Ana Amélia Moreira |
contributor_str_mv |
Lira, Ana Amélia Moreira |
dc.subject.por.fl_str_mv |
Farmácia Ensino de farmácia Lipídicos Nnnoestruturados CLN NLS Acetato de retinol |
topic |
Farmácia Ensino de farmácia Lipídicos Nnnoestruturados CLN NLS Acetato de retinol Nanostructured Lipid Carriers Solid Lipid Nanoparticles Retinol acetate CIENCIAS DA SAUDE::FARMACIA |
dc.subject.eng.fl_str_mv |
Nanostructured Lipid Carriers Solid Lipid Nanoparticles Retinol acetate |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA |
description |
Retinyl, derived from vitamin A, is a cosmetic active substance widely used in antiaging skin 52 treatment. Thus, the objective of this work was to obtain lipid nanoparticles (NL) containing retinol 53 acetate for cosmetic use. NL were obtained by the solvent diffusion method in the aqueous phase, 54 using only beeswax as a lipid matrix (NLS) or incorporating squalene as liquid lipid (CLN). The 55 particle size, polydispersity index, zeta potential and encapsulation efficiency of the samples were 56 determined. The in vitro release study was also performed using Franz type diffusion cells. As 57 results, all samples had a nanometric size between 143 and 774 nm, maximum IPD of 0.340 and 58 elevated PZ. The EE obtained was 99.95% and 100% for the NL obtained. The NL were able to 59 efficiently incorporate the retinol acetate. Carriers containing squalene in the lipid matrix presented 60 better results, with smaller size and more uniform size distribution, besides a PZ above 30 | mV. 61 These carriers had a sustained release profile during the study period. Thus, we conclude that under 62 the conditions employed and evaluated, CLNs have been shown to be more promising formulations 63 for the delivery of the active than NLS. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017-09-11 |
dc.date.accessioned.fl_str_mv |
2019-03-20T11:48:04Z |
dc.date.available.fl_str_mv |
2019-03-20T11:48:04Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Oliveira Neta, Paulinha Marques de. Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017 |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/10703 |
identifier_str_mv |
Oliveira Neta, Paulinha Marques de. Obtenção e caracterização de nanopartículas de cera de abelha contendo retinol. São Cristóvão, SE, 2017. Monografia (graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, 2017 |
url |
http://ri.ufs.br/jspui/handle/riufs/10703 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.initials.fl_str_mv |
Universidade Federal de Sergipe |
dc.publisher.department.fl_str_mv |
DFA - Departamento de Farmácia – São Cristóvão - Presencial |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
instname_str |
Universidade Federal de Sergipe (UFS) |
instacron_str |
UFS |
institution |
UFS |
reponame_str |
Repositório Institucional da UFS |
collection |
Repositório Institucional da UFS |
bitstream.url.fl_str_mv |
https://ri.ufs.br/jspui/bitstream/riufs/10703/3/Paulina_Marques_Oliveira_Neta.pdf.txt https://ri.ufs.br/jspui/bitstream/riufs/10703/4/Paulina_Marques_Oliveira_Neta.pdf.jpg https://ri.ufs.br/jspui/bitstream/riufs/10703/2/Paulina_Marques_Oliveira_Neta.pdf https://ri.ufs.br/jspui/bitstream/riufs/10703/1/license.txt |
bitstream.checksum.fl_str_mv |
fd42eb7c4eb6f84bd1cda65c51eb8e23 723e7d416311b6014ee4bf093e5f6226 53afefadcf0f9c4f83e3ffd24ca35501 098cbbf65c2c15e1fb2e49c5d306a44c |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS) |
repository.mail.fl_str_mv |
repositorio@academico.ufs.br |
_version_ |
1802110811191115776 |