Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina
Autor(a) principal: | |
---|---|
Data de Publicação: | 2020 |
Outros Autores: | |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/15996 |
Resumo: | The quality control of medicines through chemical product tests is of great importance in ensuring the quality of medicines. Therefore, this study aimed to compare the quality of nimesulide tablets with β-cyclodextrin (Maxsulid®) and without β-cyclodextrin (Nisulid®) as a way to investigate the current tests that are tested during the duration of clinical tests that are used in pharmaceutical conditions that include cyclodextrins in their composition, using methods described in the Brazilian Pharmacopoeia 6th edition. Given the exposure, both drugs obtain good results in most tests of physical-chemical characterization. Only Nisulid® failed due to a tablet break in the reliability test. The dosage and dissolution tests were performed through quantitative determinations using High Performance Liquid Chromatography. As expected, the results of the dosing showed that the applied methodology was inefficient for the drug with inclusion complex (Maxsulid®). On dissolution, both drugs were approved according to the criteria used in the Brazilian Pharmacopoeia, however Maxsulid® was the only one to have its recovery dissolved in 120 minutes. Thus, it is clear the importance of implementing analytical protocols applicable to new technologies applied in the production of medicines. |
id |
UFS-2_764ad110b0dad995a12e0e6fd2939edc |
---|---|
oai_identifier_str |
oai:ufs.br:riufs/15996 |
network_acronym_str |
UFS-2 |
network_name_str |
Repositório Institucional da UFS |
repository_id_str |
|
spelling |
Jesus, Mariana de OliveiraMoraes, Vitória Alves deMenezes, Paula dos Passos2022-07-26T14:09:40Z2022-07-26T14:09:40Z2020-03-10Jesus, Mariana de Oliveira ; Moraes, Vitória Alves de. Estudo comparativo do controle de qualidade de comprimidos de Nimesulida complexada e não complexada com β - ciclodextrina. São Cristóvão, 2020. Monografia (Graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2020http://ri.ufs.br/jspui/handle/riufs/15996The quality control of medicines through chemical product tests is of great importance in ensuring the quality of medicines. Therefore, this study aimed to compare the quality of nimesulide tablets with β-cyclodextrin (Maxsulid®) and without β-cyclodextrin (Nisulid®) as a way to investigate the current tests that are tested during the duration of clinical tests that are used in pharmaceutical conditions that include cyclodextrins in their composition, using methods described in the Brazilian Pharmacopoeia 6th edition. Given the exposure, both drugs obtain good results in most tests of physical-chemical characterization. Only Nisulid® failed due to a tablet break in the reliability test. The dosage and dissolution tests were performed through quantitative determinations using High Performance Liquid Chromatography. As expected, the results of the dosing showed that the applied methodology was inefficient for the drug with inclusion complex (Maxsulid®). On dissolution, both drugs were approved according to the criteria used in the Brazilian Pharmacopoeia, however Maxsulid® was the only one to have its recovery dissolved in 120 minutes. Thus, it is clear the importance of implementing analytical protocols applicable to new technologies applied in the production of medicines.O controle de qualidade de sólidos por meio de ensaios físico-químicos apresenta grande importância na garantia de qualidade de medicamentos. Diante disto, este estudo teve como objetivo comparar a qualidade de comprimidos de nimesulida com β-ciclodextrina (Maxsulid®) e sem β-ciclodextrina (Nisulid®) como forma de investigar se os testes vigentes aplicam-se às formas farmacêuticas que contenham complexos de inclusão com ciclodextrinas em sua composição, por meio de metodologias descritas na Farmacopeia Brasileira 6ª edição. Frente ao exposto, ambos os medicamentos obtiveram bons resultados na maioria dos testes de caracterização físico-química. Somente o Nisulid® apresentou falha devido à quebra de um comprimido no ensaio de friabilidade. Os testes de doseamento e dissolução foram realizados através de determinações quantitativas por meio da Cromatografia Líquida de Alta Eficiência. Como já esperado, os resultados do doseamento demonstraram que a metodologia aplicada foi ineficiente para o fármaco com complexo de inclusão (Maxsulid®). Já na dissolução, os dois medicamentos foram aprovados de acordo com os critérios estabelecidos na Farmacopeia Brasileira. Porém o Maxsulid® foi o único a obter sua totalidade dissolvida em 120 minutos. Dessa forma, fica clara a importância da implementação de protocolos analíticos adequados às novas tecnologias aplicadas na produção de medicamentos.São Cristóvão, SEporFarmáciaEnsino de farmáciaControle de qualidadeβ-ciclodextrinaNimesulidaFarmacologiaQuality controlβ-cyclodextrinNimesulideCIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOSEstudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrinaComparative study of quality control of complexed and non-complexed nimesulide tablets with β-cyclodextrininfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUniversidade Federal de SergipeDFA - Departamento de Farmácia – São Cristóvão - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessORIGINALMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdfMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdfapplication/pdf544550https://ri.ufs.br/jspui/bitstream/riufs/15996/2/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdfa100fd9eb8be7fa8252a7aaf9d360318MD52LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/15996/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51TEXTMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdf.txtMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdf.txtExtracted texttext/plain40174https://ri.ufs.br/jspui/bitstream/riufs/15996/3/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdf.txt977bb7d3c3e01c8d3c2a77df938aba95MD53THUMBNAILMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdf.jpgMariana_Oliveira_Jesus_&_Vitoria_Alves _Moraes.pdf.jpgGenerated Thumbnailimage/jpeg1586https://ri.ufs.br/jspui/bitstream/riufs/15996/4/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdf.jpg7ada65b0149860fa6968a93d7bdaf194MD54riufs/159962022-07-26 11:10:40.735oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2022-07-26T14:10:40Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
dc.title.alternative.eng.fl_str_mv |
Comparative study of quality control of complexed and non-complexed nimesulide tablets with β-cyclodextrin |
title |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
spellingShingle |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina Jesus, Mariana de Oliveira Farmácia Ensino de farmácia Controle de qualidade β-ciclodextrina Nimesulida Farmacologia Quality control β-cyclodextrin Nimesulide CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS |
title_short |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
title_full |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
title_fullStr |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
title_full_unstemmed |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
title_sort |
Estudo comparativo do controle de qualidade de comprimidos de nimesulida complexada e não complexada com β - ciclodextrina |
author |
Jesus, Mariana de Oliveira |
author_facet |
Jesus, Mariana de Oliveira Moraes, Vitória Alves de |
author_role |
author |
author2 |
Moraes, Vitória Alves de |
author2_role |
author |
dc.contributor.author.fl_str_mv |
Jesus, Mariana de Oliveira Moraes, Vitória Alves de |
dc.contributor.advisor1.fl_str_mv |
Menezes, Paula dos Passos |
contributor_str_mv |
Menezes, Paula dos Passos |
dc.subject.por.fl_str_mv |
Farmácia Ensino de farmácia Controle de qualidade β-ciclodextrina Nimesulida Farmacologia |
topic |
Farmácia Ensino de farmácia Controle de qualidade β-ciclodextrina Nimesulida Farmacologia Quality control β-cyclodextrin Nimesulide CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS |
dc.subject.eng.fl_str_mv |
Quality control β-cyclodextrin Nimesulide |
dc.subject.cnpq.fl_str_mv |
CIENCIAS DA SAUDE::FARMACIA::ANALISE E CONTROLE E MEDICAMENTOS |
description |
The quality control of medicines through chemical product tests is of great importance in ensuring the quality of medicines. Therefore, this study aimed to compare the quality of nimesulide tablets with β-cyclodextrin (Maxsulid®) and without β-cyclodextrin (Nisulid®) as a way to investigate the current tests that are tested during the duration of clinical tests that are used in pharmaceutical conditions that include cyclodextrins in their composition, using methods described in the Brazilian Pharmacopoeia 6th edition. Given the exposure, both drugs obtain good results in most tests of physical-chemical characterization. Only Nisulid® failed due to a tablet break in the reliability test. The dosage and dissolution tests were performed through quantitative determinations using High Performance Liquid Chromatography. As expected, the results of the dosing showed that the applied methodology was inefficient for the drug with inclusion complex (Maxsulid®). On dissolution, both drugs were approved according to the criteria used in the Brazilian Pharmacopoeia, however Maxsulid® was the only one to have its recovery dissolved in 120 minutes. Thus, it is clear the importance of implementing analytical protocols applicable to new technologies applied in the production of medicines. |
publishDate |
2020 |
dc.date.issued.fl_str_mv |
2020-03-10 |
dc.date.accessioned.fl_str_mv |
2022-07-26T14:09:40Z |
dc.date.available.fl_str_mv |
2022-07-26T14:09:40Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/bachelorThesis |
format |
bachelorThesis |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Jesus, Mariana de Oliveira ; Moraes, Vitória Alves de. Estudo comparativo do controle de qualidade de comprimidos de Nimesulida complexada e não complexada com β - ciclodextrina. São Cristóvão, 2020. Monografia (Graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2020 |
dc.identifier.uri.fl_str_mv |
http://ri.ufs.br/jspui/handle/riufs/15996 |
identifier_str_mv |
Jesus, Mariana de Oliveira ; Moraes, Vitória Alves de. Estudo comparativo do controle de qualidade de comprimidos de Nimesulida complexada e não complexada com β - ciclodextrina. São Cristóvão, 2020. Monografia (Graduação em Farmácia) – Departamento de Farmácia, Centro de Ciências Biológicas e da Saúde, Universidade Federal de Sergipe, São Cristóvão, SE, 2020 |
url |
http://ri.ufs.br/jspui/handle/riufs/15996 |
dc.language.iso.fl_str_mv |
por |
language |
por |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.publisher.initials.fl_str_mv |
Universidade Federal de Sergipe |
dc.publisher.department.fl_str_mv |
DFA - Departamento de Farmácia – São Cristóvão - Presencial |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UFS instname:Universidade Federal de Sergipe (UFS) instacron:UFS |
instname_str |
Universidade Federal de Sergipe (UFS) |
instacron_str |
UFS |
institution |
UFS |
reponame_str |
Repositório Institucional da UFS |
collection |
Repositório Institucional da UFS |
bitstream.url.fl_str_mv |
https://ri.ufs.br/jspui/bitstream/riufs/15996/2/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdf https://ri.ufs.br/jspui/bitstream/riufs/15996/1/license.txt https://ri.ufs.br/jspui/bitstream/riufs/15996/3/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdf.txt https://ri.ufs.br/jspui/bitstream/riufs/15996/4/Mariana_Oliveira_Jesus_%26_Vitoria_Alves%20_Moraes.pdf.jpg |
bitstream.checksum.fl_str_mv |
a100fd9eb8be7fa8252a7aaf9d360318 098cbbf65c2c15e1fb2e49c5d306a44c 977bb7d3c3e01c8d3c2a77df938aba95 7ada65b0149860fa6968a93d7bdaf194 |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS) |
repository.mail.fl_str_mv |
repositorio@academico.ufs.br |
_version_ |
1802110663690027008 |