Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe
Autor(a) principal: | |
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Data de Publicação: | 2019 |
Tipo de documento: | Trabalho de conclusão de curso |
Idioma: | por |
Título da fonte: | Repositório Institucional da UFS |
Texto Completo: | http://ri.ufs.br/jspui/handle/riufs/12363 |
Resumo: | Zingiber officinale Roscoe (Zingiberaceae) is a species widely used by traditional medicine because of its therapeutic properties, mainly related to secondary metabolites [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. [6] -shogaol, a degradation product of [6] -gingerol, is mainly found when ginger is subjected to high temperatures. According to some authors, this substance has biological activities superior to [6]-gingerol, and therefore presents greater potential as a prototype for the search of new drugs. Thus, the objective of the work is to optimize the extraction of [6]-shogaol from the rhizomes of Z. officinale using ethanol as solvent extractor. The extractions were carried out in the presence of a catalyst (p-toluenesulfonic acid), using techniques: Soxhlet (90°C, 2 h), microwave (60 s), ultrasound (50 °C, 60min), maceration 2 h), and the associations microwave / Soxhlet and ultrasound / Soxhlet. To evaluate the extraction efficiency of each process, the amount of [6] - shogaol (mg/g dry ginger) was determined by HPLC. The most efficient extraction process for obtaining [6]-shogaol was the soxhlet, used for the optimization, using factorial design 32, with temperature, extraction time, type of solvent and mass of catalyst, as study variables. The results indicated that the catalyst mass (100 mg) and extraction time (24 hours) positively affected the yield of [6]-shogaol, favoring the formation of [6]-shogaol from [6]-gingerol (1.86 mg/g). |
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Oliveira, Taís dos SantosSilva, James Almada da2019-11-11T17:50:35Z2019-11-11T17:50:35Z2019-08-28OLIVEIRA, Taís dos Santos. Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe. 2019. TCC (Graduação em Farmácia) - Universidade Federal de Sergipe, Lagarto, 2019.http://ri.ufs.br/jspui/handle/riufs/12363Zingiber officinale Roscoe (Zingiberaceae) is a species widely used by traditional medicine because of its therapeutic properties, mainly related to secondary metabolites [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. [6] -shogaol, a degradation product of [6] -gingerol, is mainly found when ginger is subjected to high temperatures. According to some authors, this substance has biological activities superior to [6]-gingerol, and therefore presents greater potential as a prototype for the search of new drugs. Thus, the objective of the work is to optimize the extraction of [6]-shogaol from the rhizomes of Z. officinale using ethanol as solvent extractor. The extractions were carried out in the presence of a catalyst (p-toluenesulfonic acid), using techniques: Soxhlet (90°C, 2 h), microwave (60 s), ultrasound (50 °C, 60min), maceration 2 h), and the associations microwave / Soxhlet and ultrasound / Soxhlet. To evaluate the extraction efficiency of each process, the amount of [6] - shogaol (mg/g dry ginger) was determined by HPLC. The most efficient extraction process for obtaining [6]-shogaol was the soxhlet, used for the optimization, using factorial design 32, with temperature, extraction time, type of solvent and mass of catalyst, as study variables. The results indicated that the catalyst mass (100 mg) and extraction time (24 hours) positively affected the yield of [6]-shogaol, favoring the formation of [6]-shogaol from [6]-gingerol (1.86 mg/g).O Zingiber officinale Roscoe (Zingiberaceae) é uma espécie bastante utilizada pela medicina tradicional devido as suas propriedades terapêuticas, relacionadas principalmente aos metabólitos secundários [6]-gingerol, [8]-gingerol, [10]-gingerol e [6]-shogaol. O [6]-shogaol, um produto de degradação do [6]-gingerol, é encontrado principalmente quando o gengibre é submetido a altas temperaturas. Segundo alguns autores, esta substância apresenta atividades biológicas superiores ao [6]- gingerol, e por isso apresenta maior potencial como protótipo para a busca de novos fármacos. Desta forma, o objetivo do trabalho é otimizar a extração de [6]-shogaol a partir dos rizomas de Z. officinale utilizando etanol como solvente extrator. As extrações foram realizadas na presença de catalisador (ácido p-toluenossulfônico), utilizando as técnicas: Soxhlet (90°C, 2 h), micro-ondas (60 s), ultrassom (50°C, 60 min), maceração (2 h), e as associações micro-ondas/Soxhlet e ultrassom/Soxhlet. Para avaliar a eficiência de extração de cada processo, a quantidade de [6]-shogaol (mg/g de gengibre seco) foi determinada por CLAE. O processo de extração mais eficiente na obtenção do [6]-shogaol foi o soxhlet, utilizado para a otimização,utilizando o planejamento fatorial 32, com temperatura, tempo de extração e massa de catalisador, como variáveis do estudo. Os resultados indicaram que a massa do catalisador (100 mg) e tempo de extração (24 horas) afetaram de forma positiva o rendimento do [6]-shogaol, favorecendo a formação do [6]-shogaol a partir do [6]-gingerol (1,86 mg/g).Lagarto, SEporGengibrePlanejamento fatorialTécnicas de extraçãoShogaolGingerExtraction techniquesFactorial planningOtimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoeOptimization of the extraction process of the [6] -shogaol of the rhizomes of zingiber officinale roscoeinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/bachelorThesisUFSDFAL - Departamento de Farmácia – Lagarto - Presencialreponame:Repositório Institucional da UFSinstname:Universidade Federal de Sergipe (UFS)instacron:UFSinfo:eu-repo/semantics/openAccessTEXTTAÍS_DOS_SANTOS_OLIVEIRA.pdf.txtTAÍS_DOS_SANTOS_OLIVEIRA.pdf.txtExtracted texttext/plain67156https://ri.ufs.br/jspui/bitstream/riufs/12363/3/TA%c3%8dS_DOS_SANTOS_OLIVEIRA.pdf.txt3e007b973e8b49dc3c5738bc31bfe45fMD53THUMBNAILTAÍS_DOS_SANTOS_OLIVEIRA.pdf.jpgTAÍS_DOS_SANTOS_OLIVEIRA.pdf.jpgGenerated Thumbnailimage/jpeg1341https://ri.ufs.br/jspui/bitstream/riufs/12363/4/TA%c3%8dS_DOS_SANTOS_OLIVEIRA.pdf.jpg5c586a69bff4f659ad5b8c9dba3e07f5MD54LICENSElicense.txtlicense.txttext/plain; charset=utf-81475https://ri.ufs.br/jspui/bitstream/riufs/12363/1/license.txt098cbbf65c2c15e1fb2e49c5d306a44cMD51ORIGINALTAÍS_DOS_SANTOS_OLIVEIRA.pdfTAÍS_DOS_SANTOS_OLIVEIRA.pdfapplication/pdf1042276https://ri.ufs.br/jspui/bitstream/riufs/12363/2/TA%c3%8dS_DOS_SANTOS_OLIVEIRA.pdf4a2baaba8c215be06b0c9b3f0aca4a4dMD52riufs/123632019-11-11 14:50:35.664oai:ufs.br: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Repositório InstitucionalPUBhttps://ri.ufs.br/oai/requestrepositorio@academico.ufs.bropendoar:2019-11-11T17:50:35Repositório Institucional da UFS - Universidade Federal de Sergipe (UFS)false |
dc.title.pt_BR.fl_str_mv |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
dc.title.alternative.eng.fl_str_mv |
Optimization of the extraction process of the [6] -shogaol of the rhizomes of zingiber officinale roscoe |
title |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
spellingShingle |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe Oliveira, Taís dos Santos Gengibre Planejamento fatorial Técnicas de extração Shogaol Ginger Extraction techniques Factorial planning |
title_short |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
title_full |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
title_fullStr |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
title_full_unstemmed |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
title_sort |
Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe |
author |
Oliveira, Taís dos Santos |
author_facet |
Oliveira, Taís dos Santos |
author_role |
author |
dc.contributor.author.fl_str_mv |
Oliveira, Taís dos Santos |
dc.contributor.advisor1.fl_str_mv |
Silva, James Almada da |
contributor_str_mv |
Silva, James Almada da |
dc.subject.por.fl_str_mv |
Gengibre Planejamento fatorial Técnicas de extração |
topic |
Gengibre Planejamento fatorial Técnicas de extração Shogaol Ginger Extraction techniques Factorial planning |
dc.subject.eng.fl_str_mv |
Shogaol Ginger Extraction techniques Factorial planning |
description |
Zingiber officinale Roscoe (Zingiberaceae) is a species widely used by traditional medicine because of its therapeutic properties, mainly related to secondary metabolites [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. [6] -shogaol, a degradation product of [6] -gingerol, is mainly found when ginger is subjected to high temperatures. According to some authors, this substance has biological activities superior to [6]-gingerol, and therefore presents greater potential as a prototype for the search of new drugs. Thus, the objective of the work is to optimize the extraction of [6]-shogaol from the rhizomes of Z. officinale using ethanol as solvent extractor. The extractions were carried out in the presence of a catalyst (p-toluenesulfonic acid), using techniques: Soxhlet (90°C, 2 h), microwave (60 s), ultrasound (50 °C, 60min), maceration 2 h), and the associations microwave / Soxhlet and ultrasound / Soxhlet. To evaluate the extraction efficiency of each process, the amount of [6] - shogaol (mg/g dry ginger) was determined by HPLC. The most efficient extraction process for obtaining [6]-shogaol was the soxhlet, used for the optimization, using factorial design 32, with temperature, extraction time, type of solvent and mass of catalyst, as study variables. The results indicated that the catalyst mass (100 mg) and extraction time (24 hours) positively affected the yield of [6]-shogaol, favoring the formation of [6]-shogaol from [6]-gingerol (1.86 mg/g). |
publishDate |
2019 |
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2019-11-11T17:50:35Z |
dc.date.available.fl_str_mv |
2019-11-11T17:50:35Z |
dc.date.issued.fl_str_mv |
2019-08-28 |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/bachelorThesis |
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bachelorThesis |
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publishedVersion |
dc.identifier.citation.fl_str_mv |
OLIVEIRA, Taís dos Santos. Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe. 2019. TCC (Graduação em Farmácia) - Universidade Federal de Sergipe, Lagarto, 2019. |
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http://ri.ufs.br/jspui/handle/riufs/12363 |
identifier_str_mv |
OLIVEIRA, Taís dos Santos. Otimização do processo de extração do [6]-shogaol dos rizomas de zingiber officinale roscoe. 2019. TCC (Graduação em Farmácia) - Universidade Federal de Sergipe, Lagarto, 2019. |
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UFS |
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DFAL - Departamento de Farmácia – Lagarto - Presencial |
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