Association between oxidative stress and inflammatory status with extrapulmonary variables in smokers

• Autor(a) principal: Lopes, Helenize Veron
• Data de Publicação: 2019
• Outros Autores: Félix, Andressa Brum, da Silva, André Felipe Santos, Brancher, Elizabeth do Canto, Prestes, Daniele, Steidl, Eduardo Matias dos Santos, Mancopes, Renata, Pasqualoto, Adriane Schmidt
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/29888
• topic: Physiotherapy; Tobacco; Oxidative stress

Objective: To evaluate oxidative stress and inflammatory status of smokers and nonsmokers and analyze the association with extrapulmonary variables. Methods: Cross-sectional, descriptive study where the sample was composed of 10 smokers and 10 nonsmokers. After spirometry, they were subjected to analysis of blood count, C-reactive protein us and TBARS and evaluation of respiratory muscle strength, functional capacity and quality of life. The homogeneity of variances was tested by Levene test, the differences between the groups were analyzed by Student t test or Mann-Whitney U test. Associations between variables were assessed by Pearson or Spearman correlation test. Results: GT introduced tobacco intake of 29,49±33,66 years/pack and daily cigarette consumption of 13,5±8,5. Difference was found between FEV1 post in groups 2,30±0,59 and 2,86±0,50 (p=0,033), FEV1/FVC post 75,07±12,62 X 85,90±4,98 (p=0,027) and leukocytes 9750±2269 X 7320±1692 (p=0,028), respectively GT and GC. There was an association between PCR-us and smoking history (p=0,007; r=0,806) and between TBARS and PEmáx (p=0,006; r=0,818), both in GT. Conclusion: Only spirometry and leukocytosis levels were evident in the differences between groups. In the GT was no association between PCR-us and smoking history and between PEmáx and TBARS. There were no associations of other variables with the levels of TBARS and PCR-us.