Characterization of oncological-hematological patients hospitalized with febrile neutropenia after chemotherapy in a university hospital

• Autor(a) principal: Horner, Christine
• Data de Publicação: 2023
• Outros Autores: Horner, Andreas
• Tipo de documento: Artigo
• Idioma: por
• Título da fonte: Saúde (Santa Maria)
• Texto Completo: https://periodicos.ufsm.br/revistasaude/article/view/74075
• topic: Neutropenia febril; Diagnóstico; Neutropenia febril induzida por quimioterapia; Febrile neutropenia; Diagnosis; Chemotherapy-induced febrile neutropenia

Introduction: Febrile neutropenia (FN) is a frequent and important complication in patients undergoing chemotherapy, potentially fatal, considered a clinical emergency, in which the immediate administration of wide spectrum antibiotics considerably reduces mortality. Studies with data available in the literature involving the characterization of hospitalized patients with post chemotherapy FN are scarce. Objective: to characterize oncological-hematological patients hospitalized with post chemotherapy febrile neutropenia in a tertiary hospital. It was an observational, cross-sectional and retrospective study, which included data from all patients hospitalized in the oncology sector of the aforementioned university hospital, during the period of this study, who had a diagnosis of leukemia, lymphoma, multiple myeloma or myeloproliferative syndromes, over 18 years old and undergoing chemotherapy treatment. Results: there was a predominance of male patients (55.77%), mean age of 40,60 years, and most were married (57.70%). In terms of profession, most of them did not fill in the medical record (42.31%). Regarding education, the majority had incomplete elementary school (42.01%), and only one had completed higher education, but without detailing the course. The majority had no comorbidities (42.31%), and acute myelocytic leukemia (38.46%) was the most frequent cancer. Two blood cultures were performed for most patients (75.00%) and gram positive were the agents with the highest frequency of isolation, 98.08% received empirical antibiotic therapy with at least one drug, and most did not receive antifungal empirical (73.08%). The number of survivors (51.92%) in the period of this study exceeded the number of deaths (48.08%). Final considerations: Immediate recognition of the patient with FN according to the risk and the adequate treatment with immediate initiation of empirical drug therapy define the patient’s survival.