Caroli syndrome in a dog

Detalhes bibliográficos
Autor(a) principal: Cecco,Bianca Santana de
Data de Publicação: 2022
Outros Autores: Lorenzett,Marina Paula, Henker,Luan Cleber, Bisol,Juliana, Soares,Aline Girotto, Trindade-Gerardi,Anelise Bonilha, Alievi,Marcelo Meller, Sonne,Luciana
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000900602
Resumo: ABSTRACT: Caroli syndrome is characterized by a combination of intrahepatic biliary ductal ectasia and congenital ductal fibrosis due to the failure of involution of ductal plates and large intrahepatic ducts. This study aims to report Caroli syndrome in a dog, with emphasis on clinical characteristics, complementary examinations, and diagnostic approach. A 1-year-old mixed-breed intact male dog was presented with a 7-day history of acute vomiting and anorexia. Clinical evaluation revealed severe jaundice, abdominal pain, dehydration, lethargy, and abdominal distension. Ultrasonography revealed hepatic cysts filled with fluid. Exploratory laparotomy was performed to clarify the imaging findings; however, the dog died shortly after surgery. Postmortem examination revealed that the liver was reduced in size and had multiple interconnected and distended saccular dilations. The bile ducts were markedly dilated and replaced a large part of the liver parenchyma. Multiple small cysts were also observed in the kidneys. Microscopically, the hepatic lesions were characterized by extensive bridging fibrosis associated with proliferating and ectatic bile ducts contiguous with the biliary tree. Marked fibrosis and small cysts were observed in the kidneys. Therefore, a final diagnosis of Caroli syndrome was made. While uncommon, this syndrome should be considered as a differential diagnosis for young dogs with biliary cysts and hepatic fibrosis.
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spelling Caroli syndrome in a dogliver cystsCaroli syndromemalformationgenetic conditionABSTRACT: Caroli syndrome is characterized by a combination of intrahepatic biliary ductal ectasia and congenital ductal fibrosis due to the failure of involution of ductal plates and large intrahepatic ducts. This study aims to report Caroli syndrome in a dog, with emphasis on clinical characteristics, complementary examinations, and diagnostic approach. A 1-year-old mixed-breed intact male dog was presented with a 7-day history of acute vomiting and anorexia. Clinical evaluation revealed severe jaundice, abdominal pain, dehydration, lethargy, and abdominal distension. Ultrasonography revealed hepatic cysts filled with fluid. Exploratory laparotomy was performed to clarify the imaging findings; however, the dog died shortly after surgery. Postmortem examination revealed that the liver was reduced in size and had multiple interconnected and distended saccular dilations. The bile ducts were markedly dilated and replaced a large part of the liver parenchyma. Multiple small cysts were also observed in the kidneys. Microscopically, the hepatic lesions were characterized by extensive bridging fibrosis associated with proliferating and ectatic bile ducts contiguous with the biliary tree. Marked fibrosis and small cysts were observed in the kidneys. Therefore, a final diagnosis of Caroli syndrome was made. While uncommon, this syndrome should be considered as a differential diagnosis for young dogs with biliary cysts and hepatic fibrosis.Universidade Federal de Santa Maria2022-01-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000900602Ciência Rural v.52 n.9 2022reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20210238info:eu-repo/semantics/openAccessCecco,Bianca Santana deLorenzett,Marina PaulaHenker,Luan CleberBisol,JulianaSoares,Aline GirottoTrindade-Gerardi,Anelise BonilhaAlievi,Marcelo MellerSonne,Lucianaeng2022-02-09T00:00:00ZRevista
dc.title.none.fl_str_mv Caroli syndrome in a dog
title Caroli syndrome in a dog
spellingShingle Caroli syndrome in a dog
Cecco,Bianca Santana de
liver cysts
Caroli syndrome
malformation
genetic condition
title_short Caroli syndrome in a dog
title_full Caroli syndrome in a dog
title_fullStr Caroli syndrome in a dog
title_full_unstemmed Caroli syndrome in a dog
title_sort Caroli syndrome in a dog
author Cecco,Bianca Santana de
author_facet Cecco,Bianca Santana de
Lorenzett,Marina Paula
Henker,Luan Cleber
Bisol,Juliana
Soares,Aline Girotto
Trindade-Gerardi,Anelise Bonilha
Alievi,Marcelo Meller
Sonne,Luciana
author_role author
author2 Lorenzett,Marina Paula
Henker,Luan Cleber
Bisol,Juliana
Soares,Aline Girotto
Trindade-Gerardi,Anelise Bonilha
Alievi,Marcelo Meller
Sonne,Luciana
author2_role author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Cecco,Bianca Santana de
Lorenzett,Marina Paula
Henker,Luan Cleber
Bisol,Juliana
Soares,Aline Girotto
Trindade-Gerardi,Anelise Bonilha
Alievi,Marcelo Meller
Sonne,Luciana
dc.subject.por.fl_str_mv liver cysts
Caroli syndrome
malformation
genetic condition
topic liver cysts
Caroli syndrome
malformation
genetic condition
description ABSTRACT: Caroli syndrome is characterized by a combination of intrahepatic biliary ductal ectasia and congenital ductal fibrosis due to the failure of involution of ductal plates and large intrahepatic ducts. This study aims to report Caroli syndrome in a dog, with emphasis on clinical characteristics, complementary examinations, and diagnostic approach. A 1-year-old mixed-breed intact male dog was presented with a 7-day history of acute vomiting and anorexia. Clinical evaluation revealed severe jaundice, abdominal pain, dehydration, lethargy, and abdominal distension. Ultrasonography revealed hepatic cysts filled with fluid. Exploratory laparotomy was performed to clarify the imaging findings; however, the dog died shortly after surgery. Postmortem examination revealed that the liver was reduced in size and had multiple interconnected and distended saccular dilations. The bile ducts were markedly dilated and replaced a large part of the liver parenchyma. Multiple small cysts were also observed in the kidneys. Microscopically, the hepatic lesions were characterized by extensive bridging fibrosis associated with proliferating and ectatic bile ducts contiguous with the biliary tree. Marked fibrosis and small cysts were observed in the kidneys. Therefore, a final diagnosis of Caroli syndrome was made. While uncommon, this syndrome should be considered as a differential diagnosis for young dogs with biliary cysts and hepatic fibrosis.
publishDate 2022
dc.date.none.fl_str_mv 2022-01-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000900602
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782022000900602
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20210238
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.52 n.9 2022
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
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repository.mail.fl_str_mv
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