Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats

Detalhes bibliográficos
Autor(a) principal: Schroder,Deise Cristine
Data de Publicação: 2016
Outros Autores: Stocco,Matias Bassinello, Isoton,Deborah de Arruda, Silva,Carla Patricia Amarante e, Braga,Ísis Assis, Silva,Érica Pereira da, Maciel,Camila do Espírito Santo, Maruyama,Fernanda Harumi, Nakazato,Luciano, Aguiar,Daniel Moura de, Mendonça,Adriane Jorge, Ribeiro,Alexandre Pinto
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Ciência Rural
Texto Completo: http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601053
Resumo: ABSTRACT: This study aimed to evaluate the effects of firocoxib for controlling experimentally-induced breakdown of the blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats. Thirty two cats with no ocular abnormalities were used. Groups (n=8/each) were formed with healthy cats that received 5mg g-1 of oral firocoxib (FH) or no treatment (CH) on day 0; seropositive cats for anti -T. gondii specific immunoglobulin G (IgG) were grouped (n=8/each) and treated in a similar fashion (FT and CT). On day 1, cats of all groups received the same treatment protocol, and 1h later, aqueocentesis was performed under general anesthesia (M0). Following 1h, the same procedure was repeated (M1). Quantitation of aqueous humor total protein and prostaglandin E2 (PGE2) were determined. Aqueous samples of seropositive cats were tested for anti- T. gondii specific IgG. In M0, aqueous samples of CT showed a significantly higher concentration of PGE2 in comparison with other groups (P<0.05). In all groups, PGE2 concentration increased significantly from M0 to M1 (P=0.001). PGE2 values did not change significantly between groups in M1 (P=0.17). Anti- T. gondii specific IgG were reported only in samples of M1, and aqueous titers did not change significantly between FT and CT (P=0.11). Although we have observed that aqueous humor PGE2 levels were significantly higher in cats of CT group during M0, such increase was not able to break the blood-aqueous barrier and cause anterior uveitis. Firocoxib did not prevent intraocular inflammation after aqueocentesis, in healthy and toxoplasmosis-seropositive cats.
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spelling Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive catsaqueous humorintraocular inflammationNSADstoxoplasmosisABSTRACT: This study aimed to evaluate the effects of firocoxib for controlling experimentally-induced breakdown of the blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats. Thirty two cats with no ocular abnormalities were used. Groups (n=8/each) were formed with healthy cats that received 5mg g-1 of oral firocoxib (FH) or no treatment (CH) on day 0; seropositive cats for anti -T. gondii specific immunoglobulin G (IgG) were grouped (n=8/each) and treated in a similar fashion (FT and CT). On day 1, cats of all groups received the same treatment protocol, and 1h later, aqueocentesis was performed under general anesthesia (M0). Following 1h, the same procedure was repeated (M1). Quantitation of aqueous humor total protein and prostaglandin E2 (PGE2) were determined. Aqueous samples of seropositive cats were tested for anti- T. gondii specific IgG. In M0, aqueous samples of CT showed a significantly higher concentration of PGE2 in comparison with other groups (P<0.05). In all groups, PGE2 concentration increased significantly from M0 to M1 (P=0.001). PGE2 values did not change significantly between groups in M1 (P=0.17). Anti- T. gondii specific IgG were reported only in samples of M1, and aqueous titers did not change significantly between FT and CT (P=0.11). Although we have observed that aqueous humor PGE2 levels were significantly higher in cats of CT group during M0, such increase was not able to break the blood-aqueous barrier and cause anterior uveitis. Firocoxib did not prevent intraocular inflammation after aqueocentesis, in healthy and toxoplasmosis-seropositive cats.Universidade Federal de Santa Maria2016-06-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersiontext/htmlhttp://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601053Ciência Rural v.46 n.6 2016reponame:Ciência Ruralinstname:Universidade Federal de Santa Maria (UFSM)instacron:UFSM10.1590/0103-8478cr20151051info:eu-repo/semantics/openAccessSchroder,Deise CristineStocco,Matias BassinelloIsoton,Deborah de ArrudaSilva,Carla Patricia Amarante eBraga,Ísis AssisSilva,Érica Pereira daMaciel,Camila do Espírito SantoMaruyama,Fernanda HarumiNakazato,LucianoAguiar,Daniel Moura deMendonça,Adriane JorgeRibeiro,Alexandre Pintoeng2016-05-03T00:00:00ZRevista
dc.title.none.fl_str_mv Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
title Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
spellingShingle Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
Schroder,Deise Cristine
aqueous humor
intraocular inflammation
NSADs
toxoplasmosis
title_short Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
title_full Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
title_fullStr Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
title_full_unstemmed Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
title_sort Firocoxib on aqueous humor prostaglandin E 2 levels for controlling experimentally-induced breakdown of blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats
author Schroder,Deise Cristine
author_facet Schroder,Deise Cristine
Stocco,Matias Bassinello
Isoton,Deborah de Arruda
Silva,Carla Patricia Amarante e
Braga,Ísis Assis
Silva,Érica Pereira da
Maciel,Camila do Espírito Santo
Maruyama,Fernanda Harumi
Nakazato,Luciano
Aguiar,Daniel Moura de
Mendonça,Adriane Jorge
Ribeiro,Alexandre Pinto
author_role author
author2 Stocco,Matias Bassinello
Isoton,Deborah de Arruda
Silva,Carla Patricia Amarante e
Braga,Ísis Assis
Silva,Érica Pereira da
Maciel,Camila do Espírito Santo
Maruyama,Fernanda Harumi
Nakazato,Luciano
Aguiar,Daniel Moura de
Mendonça,Adriane Jorge
Ribeiro,Alexandre Pinto
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.contributor.author.fl_str_mv Schroder,Deise Cristine
Stocco,Matias Bassinello
Isoton,Deborah de Arruda
Silva,Carla Patricia Amarante e
Braga,Ísis Assis
Silva,Érica Pereira da
Maciel,Camila do Espírito Santo
Maruyama,Fernanda Harumi
Nakazato,Luciano
Aguiar,Daniel Moura de
Mendonça,Adriane Jorge
Ribeiro,Alexandre Pinto
dc.subject.por.fl_str_mv aqueous humor
intraocular inflammation
NSADs
toxoplasmosis
topic aqueous humor
intraocular inflammation
NSADs
toxoplasmosis
description ABSTRACT: This study aimed to evaluate the effects of firocoxib for controlling experimentally-induced breakdown of the blood-aqueous barrier in healthy and Toxoplasma gondii -seropositive cats. Thirty two cats with no ocular abnormalities were used. Groups (n=8/each) were formed with healthy cats that received 5mg g-1 of oral firocoxib (FH) or no treatment (CH) on day 0; seropositive cats for anti -T. gondii specific immunoglobulin G (IgG) were grouped (n=8/each) and treated in a similar fashion (FT and CT). On day 1, cats of all groups received the same treatment protocol, and 1h later, aqueocentesis was performed under general anesthesia (M0). Following 1h, the same procedure was repeated (M1). Quantitation of aqueous humor total protein and prostaglandin E2 (PGE2) were determined. Aqueous samples of seropositive cats were tested for anti- T. gondii specific IgG. In M0, aqueous samples of CT showed a significantly higher concentration of PGE2 in comparison with other groups (P<0.05). In all groups, PGE2 concentration increased significantly from M0 to M1 (P=0.001). PGE2 values did not change significantly between groups in M1 (P=0.17). Anti- T. gondii specific IgG were reported only in samples of M1, and aqueous titers did not change significantly between FT and CT (P=0.11). Although we have observed that aqueous humor PGE2 levels were significantly higher in cats of CT group during M0, such increase was not able to break the blood-aqueous barrier and cause anterior uveitis. Firocoxib did not prevent intraocular inflammation after aqueocentesis, in healthy and toxoplasmosis-seropositive cats.
publishDate 2016
dc.date.none.fl_str_mv 2016-06-01
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601053
url http://old.scielo.br/scielo.php?script=sci_arttext&pid=S0103-84782016000601053
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv 10.1590/0103-8478cr20151051
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv text/html
dc.publisher.none.fl_str_mv Universidade Federal de Santa Maria
publisher.none.fl_str_mv Universidade Federal de Santa Maria
dc.source.none.fl_str_mv Ciência Rural v.46 n.6 2016
reponame:Ciência Rural
instname:Universidade Federal de Santa Maria (UFSM)
instacron:UFSM
instname_str Universidade Federal de Santa Maria (UFSM)
instacron_str UFSM
institution UFSM
reponame_str Ciência Rural
collection Ciência Rural
repository.name.fl_str_mv
repository.mail.fl_str_mv
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