Sintese e avaliação como fotossensibilizadores de novos triazoil-fulerenos funcionalizados com AZT e com calcogenos derivados de AZT

• Autor(a) principal: Ravanello, Bruno Brisólla
• Data de Publicação: 2014
• Tipo de documento: Dissertação
• Idioma: por
• Título da fonte: Manancial - Repositório Digital da UFSM
• dARK ID: ark:/26339/0013000016zkw
• Texto Completo: http://repositorio.ufsm.br/handle/1/10588
• topic: Fulereno; Terapia fotodinâmica; Fotossensibilizador; CNPQ::CIENCIAS EXATAS E DA TERRA::QUIMICA

Herein we report the synthesis of a new class of AZT-functionalized fullerenes. The synthetic strategic furnished the desired products in few reactional steps, in a convergent manner, in yields ranging from 22 to 43 %. Studies of reaction conditions were also performed. Time, temperature, catalyst adding and solvents, involved in the main step of the synthesis were optimized. The target molecules were evaluated as photosensitizers for use in photodynamic therapy. The generation of singlet oxigen were confirmed using the singlet oxigen scavenger DPBF (1,3-diphenylisobenzofuran). Analysing the decay of the absorbance of DPBF at 418 nm, it was possible to measure the generation of singlet oxygen (1O2). In this context, the respective compounds showed a potential ability of 1O2 generation, demonstrating a prominent application of these molecules as photosensitizer