Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/6161 http://dx.doi.org/10.1590/S1807-59322011001100002 |
Resumo: | OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. |
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Etto, Leina Y [UNIFESP]Morel, Vânia Maris [UNIFESP]Silva, Vanderleia C [UNIFESP]Hungria, Vania Tietsche de MoraesCiconelli, Rozana Mesquita [UNIFESP]Almeida, Manuella S. S [UNIFESP]Oliveira, José Salvador Rodrigues de [UNIFESP]Barros, José CarlosDurie, Brian GColleoni, Gisele Wally Braga [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Santa Casa de Misericórdia de São Paulo Faculdade de Ciências MédicasCedars-Sinai Outpatient Cancer Center2015-06-14T13:42:45Z2015-06-14T13:42:45Z2011-01-01Clinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1855-1859, 2011.1807-5932http://repositorio.unifesp.br/handle/11600/6161http://dx.doi.org/10.1590/S1807-59322011001100002S1807-59322011001100002.pdfS1807-5932201100110000210.1590/S1807-59322011001100002WOS:000297498600002OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients.Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)Universidade Federal de São Paulo (UNIFESP)Santa Casa de Misericórdia de São Paulo Faculdade de Ciências MédicasUniversidade Federal de São Paulo (UNIFESP) Departamento de MedicinaCedars-Sinai Outpatient Cancer CenterUNIFESP, Depto. de MedicinaSciELO1855-1859engFaculdade de Medicina / USPClinicsMyelomaQuality of lifeSF-36QLQ-C30TransplantationAutologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patientsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS1807-59322011001100002.pdfapplication/pdf236725${dspace.ui.url}/bitstream/11600/6161/1/S1807-59322011001100002.pdf47afbcfec92e8a14d11b23c41c6d6fbaMD51open accessTEXTS1807-59322011001100002.pdf.txtS1807-59322011001100002.pdf.txtExtracted texttext/plain23328${dspace.ui.url}/bitstream/11600/6161/2/S1807-59322011001100002.pdf.txt46f3406654b5e486c9c662a585c3e9a6MD52open access11600/61612021-10-05 21:53:32.551open accessoai:repositorio.unifesp.br:11600/6161Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-06T00:53:32Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
title |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
spellingShingle |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients Etto, Leina Y [UNIFESP] Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
title_short |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
title_full |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
title_fullStr |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
title_full_unstemmed |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
title_sort |
Autologous stem cell transplantation improves quality of life in economically challenged, Brazilian multiple myeloma patients |
author |
Etto, Leina Y [UNIFESP] |
author_facet |
Etto, Leina Y [UNIFESP] Morel, Vânia Maris [UNIFESP] Silva, Vanderleia C [UNIFESP] Hungria, Vania Tietsche de Moraes Ciconelli, Rozana Mesquita [UNIFESP] Almeida, Manuella S. S [UNIFESP] Oliveira, José Salvador Rodrigues de [UNIFESP] Barros, José Carlos Durie, Brian G Colleoni, Gisele Wally Braga [UNIFESP] |
author_role |
author |
author2 |
Morel, Vânia Maris [UNIFESP] Silva, Vanderleia C [UNIFESP] Hungria, Vania Tietsche de Moraes Ciconelli, Rozana Mesquita [UNIFESP] Almeida, Manuella S. S [UNIFESP] Oliveira, José Salvador Rodrigues de [UNIFESP] Barros, José Carlos Durie, Brian G Colleoni, Gisele Wally Braga [UNIFESP] |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Santa Casa de Misericórdia de São Paulo Faculdade de Ciências Médicas Cedars-Sinai Outpatient Cancer Center |
dc.contributor.author.fl_str_mv |
Etto, Leina Y [UNIFESP] Morel, Vânia Maris [UNIFESP] Silva, Vanderleia C [UNIFESP] Hungria, Vania Tietsche de Moraes Ciconelli, Rozana Mesquita [UNIFESP] Almeida, Manuella S. S [UNIFESP] Oliveira, José Salvador Rodrigues de [UNIFESP] Barros, José Carlos Durie, Brian G Colleoni, Gisele Wally Braga [UNIFESP] |
dc.subject.eng.fl_str_mv |
Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
topic |
Myeloma Quality of life SF-36 QLQ-C30 Transplantation |
description |
OBJECTIVES: 1) To characterize the impact of multiple myeloma on the quality of life of patients treated in two public institutions in São Paulo State, Brazil, using a generic Short Form 36 Health Survey and a questionnaire specific for oncologic patients (QLQ-C30) upon diagnosis, after the clinical treatment, and at day +100 after autologous stem cell transplantation; 2) to evaluate whether autologous stem cell transplantation can improve the quality of life of our economically challenged population aside from providing a clinical benefit and disease control. METHODS: We evaluated 49 patients with multiple myeloma (a total of 70 interviews) using the two questionnaires. The scores upon diagnosis, post-treatment/pre-autologous stem cell transplantation, and at D+100 were compared using ANOVA (a comparison of the three groups), post hoc tests (two-by-two comparisons of the three groups), and paired t-tests (the same case at two different times). RESULTS: Of the included patients, 87.8% had a family budget under US $600 (economic class C, D, or E) per month. The generic Short Form 36 Health Survey questionnaire demonstrated that physical function, role-physical, and bodily pain indices were statistically different across all three groups, favoring the D+100 autologous stem cell transplantation group (ANOVA). The questionnaire specific for oncologic patients, the QLQ-C30 questionnaire, confirmed what had been demonstrated by the Short Form 36 Health Survey with respect to physical function and bodily pain, with improvements in role functioning, fatigue, and lack of appetite and constipation, favoring the D+100 autologous stem cell transplant group (ANOVA). The post hoc tests and paired t-tests confirmed a better outcome after autologous stem cell transplantation CONCLUSION: The questionnaire specific for cancer patients seems to be more informative than the generic Short Form 36 Health Survey questionnaire and reflects the real benefit of autologous stem cell transplantation in the quality of life of multiple myeloma patients in two public Brazilian institutions that provide assistance for economically challenged patients. |
publishDate |
2011 |
dc.date.issued.fl_str_mv |
2011-01-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:42:45Z |
dc.date.available.fl_str_mv |
2015-06-14T13:42:45Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Clinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1855-1859, 2011. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/6161 http://dx.doi.org/10.1590/S1807-59322011001100002 |
dc.identifier.issn.none.fl_str_mv |
1807-5932 |
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S1807-59322011001100002.pdf |
dc.identifier.scielo.none.fl_str_mv |
S1807-59322011001100002 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S1807-59322011001100002 |
dc.identifier.wos.none.fl_str_mv |
WOS:000297498600002 |
identifier_str_mv |
Clinics. Faculdade de Medicina / USP, v. 66, n. 11, p. 1855-1859, 2011. 1807-5932 S1807-59322011001100002.pdf S1807-59322011001100002 10.1590/S1807-59322011001100002 WOS:000297498600002 |
url |
http://repositorio.unifesp.br/handle/11600/6161 http://dx.doi.org/10.1590/S1807-59322011001100002 |
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eng |
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Clinics |
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openAccess |
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1855-1859 |
dc.publisher.none.fl_str_mv |
Faculdade de Medicina / USP |
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Faculdade de Medicina / USP |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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