The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry
Autor(a) principal: | |
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Data de Publicação: | 2017 |
Outros Autores: | , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0181428 https://repositorio.unifesp.br/handle/11600/53441 |
Resumo: | Our objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario. |
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Kara-Jose, Andrea C. [UNIFESP]Melo, Luiz Alberto S., Jr. [UNIFESP]Esporcatte, Bruno L. B. {UNIFESP]Endo, Angelica T. N. H. [UNIFESP]Leite, Mauro Toledo [UNIFESP]Tavares, Ivan Maynart [UNIFESP]2020-06-26T16:30:15Z2020-06-26T16:30:15Z2017http://dx.doi.org/10.1371/journal.pone.0181428Plos One. San Francisco, v. 12, n. 7, p. -, 2017.1932-6203https://repositorio.unifesp.br/handle/11600/53441WOS000406634500071.pdf10.1371/journal.pone.0181428WOS:000406634500071Our objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario.CAPES/Ministry of Education of BrazilCNPq/Ministry of Science and Technology of BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, Escola Paulista Med, Dept Ophthalmol & Visual Sci, Glaucoma Div, Sao Paulo, SP, BrazilCAPESCNPqWeb of Science-engPublic Library SciencePlos OneThe disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetryinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleSan Francisco127info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000406634500071.pdfapplication/pdf6745966${dspace.ui.url}/bitstream/11600/53441/1/WOS000406634500071.pdfed0db7da7117253db2d447abc1e8a6acMD51open accessTEXTWOS000406634500071.pdf.txtWOS000406634500071.pdf.txtExtracted texttext/plain15${dspace.ui.url}/bitstream/11600/53441/2/WOS000406634500071.pdf.txt429079e52f342c49301a02e207bfde06MD52open accessTHUMBNAILWOS000406634500071.pdf.jpgWOS000406634500071.pdf.jpgIM Thumbnailimage/jpeg7208${dspace.ui.url}/bitstream/11600/53441/4/WOS000406634500071.pdf.jpg6f2e549d6f35fd025ea01adb51325006MD54open access11600/534412022-08-01 10:32:52.855open accessoai:repositorio.unifesp.br:11600/53441Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:26:57.452791Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
title |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
spellingShingle |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry Kara-Jose, Andrea C. [UNIFESP] |
title_short |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
title_full |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
title_fullStr |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
title_full_unstemmed |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
title_sort |
The disc damage likelihood scale: Diagnostic accuracy and correlations with cup-to-disc ratio, structural tests and standard automated perimetry |
author |
Kara-Jose, Andrea C. [UNIFESP] |
author_facet |
Kara-Jose, Andrea C. [UNIFESP] Melo, Luiz Alberto S., Jr. [UNIFESP] Esporcatte, Bruno L. B. {UNIFESP] Endo, Angelica T. N. H. [UNIFESP] Leite, Mauro Toledo [UNIFESP] Tavares, Ivan Maynart [UNIFESP] |
author_role |
author |
author2 |
Melo, Luiz Alberto S., Jr. [UNIFESP] Esporcatte, Bruno L. B. {UNIFESP] Endo, Angelica T. N. H. [UNIFESP] Leite, Mauro Toledo [UNIFESP] Tavares, Ivan Maynart [UNIFESP] |
author2_role |
author author author author author |
dc.contributor.author.fl_str_mv |
Kara-Jose, Andrea C. [UNIFESP] Melo, Luiz Alberto S., Jr. [UNIFESP] Esporcatte, Bruno L. B. {UNIFESP] Endo, Angelica T. N. H. [UNIFESP] Leite, Mauro Toledo [UNIFESP] Tavares, Ivan Maynart [UNIFESP] |
description |
Our objective was to compare the diagnostic accuracies of and to determine the correlations between the disc damage likelihood scale (DDLS) and anatomical and functional tests used for glaucoma detection. A total of 54 healthy subjects (54 eyes) and 47 primary open-angle glaucoma patients (47 eyes) were included in this cross-sectional observational study. DDLS scores and cup-to-disc (C/D) ratios were evaluated. Subjects underwent standard automated perimetry (SAP), optic disc and retinal nerve fiber layer (RNFL) imaging with time and spectral-domain optical coherence tomography (TD and SD-OCT), Heidelberg Retina Tomograph (HRT II), and scanning laser polarimetry (GDx-VCC). Areas under the receiver operating characteristic curves (AROCs) for DDLS and diagnostic tests parameters were calculated. DDLS correlations (Spearman's rank) among these parameters were analyzed. Fifty-four eyes were healthy and 47 had glaucoma, including 16 preperimetric glaucoma. DDLS, vertical and horizontal C/D ratios had the largest AROCs (0.92, 0.94 and 0.91, respectively). DDLS diagnostic accuracy was better than the accuracies of HRT II parameters, TD and SD-OCT RNFL thicknesses, and SAP mean deviation (MD) index. There were no significant differences between the accuracies of the DDLS and the C/D ratios, TD-OCT vertical (0.89) and horizontal (0.86) C/D ratios, TD-OCT C/D area ratio (0.89), and GDx-VCC NFI (0.81). DDLS showed significant strong correlations with vertical (r = 0.79) and horizontal (0.74) C/D ratios, and with the parameters vertical C/D ratio and C/D area ratio from HRT II (both 0.77) and TD-OCT (0.75 and 0.72, respectively). DDLS had significant moderate correlations with most of the other structural measurements and SAP MD. The optic disc clinical evaluation with DDLS system and C/D ratio demonstrated excellent accuracy in distinguishing glaucomatous from healthy eyes. DDLS had moderate to strong correlations with most structural and functional parameters. These findings stress the importance of optic disc clinical examination to detect glaucoma in a clinical scenario. |
publishDate |
2017 |
dc.date.issued.fl_str_mv |
2017 |
dc.date.accessioned.fl_str_mv |
2020-06-26T16:30:15Z |
dc.date.available.fl_str_mv |
2020-06-26T16:30:15Z |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
dc.identifier.].fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0181428 |
dc.identifier.citation.fl_str_mv |
Plos One. San Francisco, v. 12, n. 7, p. -, 2017. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/53441 |
dc.identifier.issn.none.fl_str_mv |
1932-6203 |
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WOS000406634500071.pdf |
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10.1371/journal.pone.0181428 |
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http://dx.doi.org/10.1371/journal.pone.0181428 https://repositorio.unifesp.br/handle/11600/53441 |
identifier_str_mv |
Plos One. San Francisco, v. 12, n. 7, p. -, 2017. 1932-6203 WOS000406634500071.pdf 10.1371/journal.pone.0181428 WOS:000406634500071 |
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