Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://ar.iiarjournals.org/content/36/4/1955.long https://repositorio.unifesp.br/handle/11600/56097 |
Resumo: | In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease |
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Repositório Institucional da UNIFESP |
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3465 |
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Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast CancerOral mucosa cellsbreast cancerchemotherapymicronucleus testIn addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this diseasehowever, the therapy may induce damage to the patient's genetic material. Thus, the aim of this study was to evaluate putative cytotavic and mutagenic effects induced by chemotherapy in women diagnosed with breast cancer. For this purpose, a cross-sectional study was carried out in 42 women, aged 18 to 70 years, allocated according to the diagnosis and stage of breast cancer treatment: control group (healthy) (n=15), chemotherapy group (n=11) and post -chemotherapy group (n=16). Cytotoxicity and mutagenicity were analyzed by the micronucleus test in buccal mucosa cells. A higher frequency (p<0.05) of micronucleated cells was detected in the chemotherapy and post -chemotherapy groups when compared to the control. A higher frequency (p<0.05) of karyorrhexis and pyknosis in the chemotherapy group was also noted. Taken together, our results indicate that chemotherapy induces mutagenicity and cytotavicity in buccal mucosa cells of women diagnosed with breast cancer, being persistent after finishing their treatment.Univ Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Management & Hlth Care, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Biosci, Sao Paulo, SP, BrazilUniv Fed Sao Paulo, UNIFESP, Dept Management & Hlth Care, Sao Paulo, SP, BrazilWeb of ScienceInt Inst Anticancer Research2020-07-22T13:23:12Z2020-07-22T13:23:12Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion1955-1958http://ar.iiarjournals.org/content/36/4/1955.longAnticancer Research. Athens, v. 36, n. 4, p. 1955-1958, 2016.0250-7005https://repositorio.unifesp.br/handle/11600/56097WOS:000375450600067engAnticancer ResearchAthensinfo:eu-repo/semantics/openAccessSouza, Ana Carolina Flygare [UNIFESP]Silva, Victor Hugo Pereira da [UNIFESP]Seixas, Camila [UNIFESP]Scudeller, Tânia Terezinha [UNIFESP]Amaral, Maria Teresa Pace do [UNIFESP]Ribeiro, Daniel Araki [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-08-11T13:23:45Zoai:repositorio.unifesp.br/:11600/56097Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-08-11T13:23:45Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| title |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| spellingShingle |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer Souza, Ana Carolina Flygare [UNIFESP] Oral mucosa cells breast cancer chemotherapy micronucleus test |
| title_short |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| title_full |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| title_fullStr |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| title_full_unstemmed |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| title_sort |
Cytogenetic Biomonitoring in Buccal Mucosa Cells from Women Submitted to Chemotherapy After Mastectomy for Breast Cancer |
| author |
Souza, Ana Carolina Flygare [UNIFESP] |
| author_facet |
Souza, Ana Carolina Flygare [UNIFESP] Silva, Victor Hugo Pereira da [UNIFESP] Seixas, Camila [UNIFESP] Scudeller, Tânia Terezinha [UNIFESP] Amaral, Maria Teresa Pace do [UNIFESP] Ribeiro, Daniel Araki [UNIFESP] |
| author_role |
author |
| author2 |
Silva, Victor Hugo Pereira da [UNIFESP] Seixas, Camila [UNIFESP] Scudeller, Tânia Terezinha [UNIFESP] Amaral, Maria Teresa Pace do [UNIFESP] Ribeiro, Daniel Araki [UNIFESP] |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Souza, Ana Carolina Flygare [UNIFESP] Silva, Victor Hugo Pereira da [UNIFESP] Seixas, Camila [UNIFESP] Scudeller, Tânia Terezinha [UNIFESP] Amaral, Maria Teresa Pace do [UNIFESP] Ribeiro, Daniel Araki [UNIFESP] |
| dc.subject.por.fl_str_mv |
Oral mucosa cells breast cancer chemotherapy micronucleus test |
| topic |
Oral mucosa cells breast cancer chemotherapy micronucleus test |
| description |
In addition to surgery, one of the most widely applied treatments for breast cancer is chemotherapy. Chemotherapy is currently considered efficient in curing this disease |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-07-22T13:23:12Z 2020-07-22T13:23:12Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://ar.iiarjournals.org/content/36/4/1955.long Anticancer Research. Athens, v. 36, n. 4, p. 1955-1958, 2016. 0250-7005 https://repositorio.unifesp.br/handle/11600/56097 WOS:000375450600067 |
| url |
http://ar.iiarjournals.org/content/36/4/1955.long https://repositorio.unifesp.br/handle/11600/56097 |
| identifier_str_mv |
Anticancer Research. Athens, v. 36, n. 4, p. 1955-1958, 2016. 0250-7005 WOS:000375450600067 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Anticancer Research |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
1955-1958 |
| dc.coverage.none.fl_str_mv |
Athens |
| dc.publisher.none.fl_str_mv |
Int Inst Anticancer Research |
| publisher.none.fl_str_mv |
Int Inst Anticancer Research |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
| repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
| _version_ |
1814268332483805184 |