Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2016 |
| Outros Autores: | , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1016/j.bjorl.2015.03.014 https://repositorio.unifesp.br/handle/11600/57835 |
Resumo: | Introduction: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. Objective: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. Methods: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. Results: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p=0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. Conclusion: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. |
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Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitisTerapia tópica de irrigação nasal de alto volume com solução de budesonida em rinossinusite crônica de difícil tratamentoSinusitisNasal polypsTherapeutic irrigationsCorticosteroidsEndoscopySinusitePólipos nasaisIrrigação terapêuticaCorticosteroidesEndoscopiaIntroduction: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. Objective: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. Methods: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. Results: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p=0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. Conclusion: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda.Introdução: A rinossinusite crônica (RSC) de difícil tratamento é aquela inadequadamente controlada com cirurgia, corticosteroides tópicos em spray e até dois ciclos de medicação sistêmica em um ano. Atualmente, tem sido preconizado o uso de irrigações nasais de corticosteroides em alto volume para seu tratamento. Objetivo: Avaliar o uso da terapia tópica de irrigações nasais com budesonida em alto volume nos pacientes com RSC de difícil tratamento. Método: Estudo prospectivo de intervenção não controlado em RSC de difícil tratamento com 3 meses de terapia tópica de irrigação (1 mg de budesonida diluído em 500 mL de soro fisiológico para ser utilizado em dois dias). Realizada avaliação subjetiva (melhora clínica satisfatória) e objetiva (questionário SNOT-22 e classificação endoscópica de Lund-Kennedy). Resultados: Foram incluídos 16 pacientes, sendo que 13 (81,3%) consideraram sua melhora clínica satisfatória. Houve melhora significante das médias de SNOT-22 (50,2 a 29,6; p = 0,006) e de Lund-Kennedy (8,8 a 5,1; p = 0,01). Individualmente, 75% dos pacientes apresentaram melhora do SNOT-22 e 75%, do Lund-Kennedy. Conclusão: A terapia tópica de irrigação de alto volume de corticosteroide é uma boa opção no controle clínico dos pacientes com rinossinusite crônica de difícil tratamento, com controle adequado de 81,3% destes pacientes e melhora significante do SNOT-22 e do Lund-Kennedy. © 2015 Associação Brasileira de Otorrinolaringologia e Cirurgia Cérvico-Facial. Published by Elsevier Editora Ltda. This is an open access article under the CC BY- license (https://creativecommons. org/licenses/by/4.0/).Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Otorhinolaryngol & Head & Neck Surg, Sect Rhinol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Otorhinolaryngol & Head & Neck Surg, Sect Rhinol, Sao Paulo, SP, BrazilWeb of ScienceAssoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial2020-08-21T17:00:00Z2020-08-21T17:00:00Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion191-197application/pdfapplication/pdfhttp://dx.doi.org/10.1016/j.bjorl.2015.03.014Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 82, n. 2, p. 191-197, 2016.10.1016/j.bjorl.2015.03.014S1808-86942016000200191-pt.pdfS1808-86942016000200191-en.pdf1808-8694S1808-86942016000200191https://repositorio.unifesp.br/handle/11600/57835WOS:000374809800011engBrazilian Journal Of OtorhinolaryngologySao Pauloinfo:eu-repo/semantics/openAccessKosugi, Eduardo Macoto [UNIFESP]Moussalem, Guilherme Figner [UNIFESP]Simoes, Juliana Caminha [UNIFESP]Felici de Souza, Rafael de Paula e Silva [UNIFESP]Chen, Vitor Guo [UNIFESP]Neto, Paulo Saraceni [UNIFESP]Mendes Neto, Jose Arruda [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-01T13:38:57Zoai:repositorio.unifesp.br/:11600/57835Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-01T13:38:57Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis Terapia tópica de irrigação nasal de alto volume com solução de budesonida em rinossinusite crônica de difícil tratamento |
| title |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| spellingShingle |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis Kosugi, Eduardo Macoto [UNIFESP] Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy Sinusite Pólipos nasais Irrigação terapêutica Corticosteroides Endoscopia |
| title_short |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| title_full |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| title_fullStr |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| title_full_unstemmed |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| title_sort |
Topical therapy with high-volume budesonide nasal irrigations in difficult-to-treat chronic rhinosinusitis |
| author |
Kosugi, Eduardo Macoto [UNIFESP] |
| author_facet |
Kosugi, Eduardo Macoto [UNIFESP] Moussalem, Guilherme Figner [UNIFESP] Simoes, Juliana Caminha [UNIFESP] Felici de Souza, Rafael de Paula e Silva [UNIFESP] Chen, Vitor Guo [UNIFESP] Neto, Paulo Saraceni [UNIFESP] Mendes Neto, Jose Arruda [UNIFESP] |
| author_role |
author |
| author2 |
Moussalem, Guilherme Figner [UNIFESP] Simoes, Juliana Caminha [UNIFESP] Felici de Souza, Rafael de Paula e Silva [UNIFESP] Chen, Vitor Guo [UNIFESP] Neto, Paulo Saraceni [UNIFESP] Mendes Neto, Jose Arruda [UNIFESP] |
| author2_role |
author author author author author author |
| dc.contributor.author.fl_str_mv |
Kosugi, Eduardo Macoto [UNIFESP] Moussalem, Guilherme Figner [UNIFESP] Simoes, Juliana Caminha [UNIFESP] Felici de Souza, Rafael de Paula e Silva [UNIFESP] Chen, Vitor Guo [UNIFESP] Neto, Paulo Saraceni [UNIFESP] Mendes Neto, Jose Arruda [UNIFESP] |
| dc.subject.por.fl_str_mv |
Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy Sinusite Pólipos nasais Irrigação terapêutica Corticosteroides Endoscopia |
| topic |
Sinusitis Nasal polyps Therapeutic irrigations Corticosteroids Endoscopy Sinusite Pólipos nasais Irrigação terapêutica Corticosteroides Endoscopia |
| description |
Introduction: Chronic rhinosinusitis (CRS) is termed difficult-to-treat when patients do not reach acceptable level of control despite adequate surgery, intranasal corticosteroid treatment and up to 2 short courses of systemic antibiotics or corticosteroids in the preceding year. Recently, high-volume corticosteroid nasal irrigations have been recommended for CRS treatment. Objective: To assess high-volume budesonide nasal irrigations for difficult-to-treat CRS. Methods: Prospective uncontrolled intervention trial. Participants were assessed before- and 3 months after nasal irrigation with 1 mg of budesonide in 500 mL of saline solution daily for 2 days. Subjective (satisfactory clinical improvement) and objective (SNOT-22 questionnaire and Lund-Kennedy endoscopic scores) assessments were performed. Results: Sixteen patients were included, and 13 (81.3%) described satisfactory clinical improvement. SNOT-22 mean scores (50.2-29.6; p = 0.006) and Lund-Kennedy mean scores (8.8-5.1; p=0.01) improved significantly. Individually, 75% of patients improved SNOT-22 scores, and 75% improved Lund-Kennedy scores after high volume budesonide nasal irrigations. Conclusion: High-volume corticosteroid nasal irrigations are a good option in difficult-to-treat CRS control of disease, reaching 81.3% success control and significant improvement of SNOT-22 and Lund-Kennedy scores. (C) 2015 Associacao Brasileira de Otorrinolaringologia e Cirurgia Cervico-Facial. Published by Elsevier Editora Ltda. |
| publishDate |
2016 |
| dc.date.none.fl_str_mv |
2016 2020-08-21T17:00:00Z 2020-08-21T17:00:00Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1016/j.bjorl.2015.03.014 Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 82, n. 2, p. 191-197, 2016. 10.1016/j.bjorl.2015.03.014 S1808-86942016000200191-pt.pdf S1808-86942016000200191-en.pdf 1808-8694 S1808-86942016000200191 https://repositorio.unifesp.br/handle/11600/57835 WOS:000374809800011 |
| url |
http://dx.doi.org/10.1016/j.bjorl.2015.03.014 https://repositorio.unifesp.br/handle/11600/57835 |
| identifier_str_mv |
Brazilian Journal Of Otorhinolaryngology. Sao Paulo, v. 82, n. 2, p. 191-197, 2016. 10.1016/j.bjorl.2015.03.014 S1808-86942016000200191-pt.pdf S1808-86942016000200191-en.pdf 1808-8694 S1808-86942016000200191 WOS:000374809800011 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Brazilian Journal Of Otorhinolaryngology |
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info:eu-repo/semantics/openAccess |
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openAccess |
| dc.format.none.fl_str_mv |
191-197 application/pdf application/pdf |
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Sao Paulo |
| dc.publisher.none.fl_str_mv |
Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial |
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Assoc Brasileira Otorrinolaringologia & Cirurgia Cervicofacial |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268301322223616 |