Precocious obesity predisposes the development of more severe cisplatin-induced acute kidney injury in young adult mice

• Autor(a) principal: Ribeiro, Rosemara Silva [UNIFESP]
• Data de Publicação: 2017
• Outros Autores: Passos, Clévia dos Santos [UNIFESP], Novaes, Antonio da Silva [UNIFESP], Maquigussa, Edgar [UNIFESP], Gloria, Maria Aparecida da [UNIFESP], Visona, Iria [UNIFESP], Ykuta, Olinda [UNIFESP], Oyama, Lila Missae [UNIFESP], Boim, Mirian Aparecida [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: https://dx.doi.org/10.1371/journal.pone.0174721; https://repositorio.unifesp.br/handle/11600/54906

Obesity and its consequences can damage the kidney over time. However, less is known about the impact of developing overweight/obesity during childhood on the kidney in adulthood and the renal impact of a superimposed acute kidney injury (AKI). This study evaluated the effect of obesity induced by a high-fat diet initiated soon after weaning on the adult life of mice and their response to superimposed nephrotoxic effects of cisplatin. C57BL/6 post weaning mice (3 weeks old) were divided into a control group (CT, n = 12) and a high-fat diet group (HF, n = 12). After 9 weeks, animals were further divided into the following groups: CT, CT treated with a single dose of cisplatin (CTCis, 20 mg/kg, i.p.), HF and HF treated with cisplatin (HFCis). The HF group exhibited higher body weight gain compatible with a moderate obesity. Obese mice presented increased visceral adiposity, hyperkalemia, sodium retention, glomerular hyperfiltration and proteinuria, without any significant changes in blood pressure and glycemia. AKI induced by cisplatin was exacerbated in obese animals with a 92% reduction in the GFR versus a 31% decrease in the CTCis group