Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2012 |
| Outros Autores: | , , , , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| Texto Completo: | http://dx.doi.org/10.1371/journal.pone.0052262 http://repositorio.unifesp.br/handle/11600/35629 |
Resumo: | We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN (R) software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia. |
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Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia FamiliesWe report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN (R) software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia.Universidade Federal de São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, Schizophrenia Program PROESQ, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Morphol & Genet Dept, São Paulo, BrazilKings Coll London, Inst Psychiat, MRC, Social Genet & Dev Psychiat Ctr, London WC2R 2LS, EnglandKings Coll London, Inst Psychiat, Natl Inst Hlth Res Biomed Res, Ctr Mental Hlth, London WC2R 2LS, EnglandUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, Interdisciplinary Lab Clin Neurosci LiNC, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Dept Psychiat, Schizophrenia Program PROESQ, São Paulo, BrazilUniversidade Federal de São Paulo UNIFESP, Morphol & Genet Dept, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 2011/00030-1Public Library ScienceUniversidade Federal de São Paulo (UNIFESP)Kings Coll LondonGadelha, Ary [UNIFESP]Ota, Vanessa Kiyomi [UNIFESP]Cano, Jose PayaMelaragno, Maria Isabel [UNIFESP]Smith, Marilia de Arruda Cardoso [UNIFESP]Mari, Jair de Jesus [UNIFESP]Bressan, Rodrigo Affonseca [UNIFESP]Belangero, Sintia Iole [UNIFESP]Breen, Gerome2016-01-24T14:28:10Z2016-01-24T14:28:10Z2012-12-31info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion6application/pdfhttp://dx.doi.org/10.1371/journal.pone.0052262Plos One. San Francisco: Public Library Science, v. 7, n. 12, 6 p., 2012.10.1371/journal.pone.0052262WOS000313872600012.pdf1932-6203http://repositorio.unifesp.br/handle/11600/35629WOS:000313872600012engPlos Oneinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-08T16:56:01Zoai:repositorio.unifesp.br/:11600/35629Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-08T16:56:01Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| title |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| spellingShingle |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families Gadelha, Ary [UNIFESP] |
| title_short |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| title_full |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| title_fullStr |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| title_full_unstemmed |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| title_sort |
Linkage Replication for Chromosomal Region 13q32 in Schizophrenia: Evidence from a Brazilian Pilot Study on Early Onset Schizophrenia Families |
| author |
Gadelha, Ary [UNIFESP] |
| author_facet |
Gadelha, Ary [UNIFESP] Ota, Vanessa Kiyomi [UNIFESP] Cano, Jose Paya Melaragno, Maria Isabel [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] Mari, Jair de Jesus [UNIFESP] Bressan, Rodrigo Affonseca [UNIFESP] Belangero, Sintia Iole [UNIFESP] Breen, Gerome |
| author_role |
author |
| author2 |
Ota, Vanessa Kiyomi [UNIFESP] Cano, Jose Paya Melaragno, Maria Isabel [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] Mari, Jair de Jesus [UNIFESP] Bressan, Rodrigo Affonseca [UNIFESP] Belangero, Sintia Iole [UNIFESP] Breen, Gerome |
| author2_role |
author author author author author author author author |
| dc.contributor.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Kings Coll London |
| dc.contributor.author.fl_str_mv |
Gadelha, Ary [UNIFESP] Ota, Vanessa Kiyomi [UNIFESP] Cano, Jose Paya Melaragno, Maria Isabel [UNIFESP] Smith, Marilia de Arruda Cardoso [UNIFESP] Mari, Jair de Jesus [UNIFESP] Bressan, Rodrigo Affonseca [UNIFESP] Belangero, Sintia Iole [UNIFESP] Breen, Gerome |
| description |
We report analyses of a Brazilian study of early onset schizophrenia (BEOS) families. We genotyped 22 members of 4 families on a linkage SNP array and report here non-parametric linkage analyses using MERLIN (R) software. We found suggestive evidence for linkage on two chromosomal regions, 13q32 and 11p15.4. A LOD score of 2.71 was observed at 13q32 with a one LOD interval extending from 60.63-92.35 cM. From simulations, this LOD score gave a genome-wide empirical corrected p = 0.33, after accounting for all markers tested. Similarly 11p15.4 showed the same maximum LOD of 2.71 and a narrower one LOD interval of 4-14 cM. of these, 13q32 has been reported to be linked to schizophrenia by multiple different studies. Thus, our study provides additional supporting evidence for an aetiological role of variants at 13q32 in schizophrenia. |
| publishDate |
2012 |
| dc.date.none.fl_str_mv |
2012-12-31 2016-01-24T14:28:10Z 2016-01-24T14:28:10Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
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info:eu-repo/semantics/publishedVersion |
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article |
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publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1371/journal.pone.0052262 Plos One. San Francisco: Public Library Science, v. 7, n. 12, 6 p., 2012. 10.1371/journal.pone.0052262 WOS000313872600012.pdf 1932-6203 http://repositorio.unifesp.br/handle/11600/35629 WOS:000313872600012 |
| url |
http://dx.doi.org/10.1371/journal.pone.0052262 http://repositorio.unifesp.br/handle/11600/35629 |
| identifier_str_mv |
Plos One. San Francisco: Public Library Science, v. 7, n. 12, 6 p., 2012. 10.1371/journal.pone.0052262 WOS000313872600012.pdf 1932-6203 WOS:000313872600012 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
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Plos One |
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info:eu-repo/semantics/openAccess |
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openAccess |
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6 application/pdf |
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Public Library Science |
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Public Library Science |
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reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
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Universidade Federal de São Paulo (UNIFESP) |
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UNIFESP |
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UNIFESP |
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Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1814268402373492736 |