Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice
Autor(a) principal: | |
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Data de Publicação: | 2014 |
Outros Autores: | , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/45103 http://www.biomed.cas.cz/physiolres/pdf/63/63_605.pdf |
Resumo: | Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R-2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice. |
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Rosa, Eloi Francisco [UNIFESP]Alves, Gabriel Andrade [UNIFESP]Luz, Jacqueline [UNIFESP]Silva, Sylvia Maria Affonso da [UNIFESP]Suchecki, Deborah [UNIFESP]Pesquero, João Bosco [UNIFESP]Aboulafia, Jeannine [UNIFESP]Nouailhetas, Nouailhetas, Viviane Louise Andree [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Univ Santo Amaro2018-06-18T11:27:05Z2018-06-18T11:27:05Z2014-01-01Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 63, n. 5, p. 605-613, 2014.0862-8408http://repositorio.unifesp.br/11600/45103http://www.biomed.cas.cz/physiolres/pdf/63/63_605.pdfWOS:000345590100011Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R-2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Univ Fed Sao Paulo, Dept Biophys, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilUniv Santo Amaro, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Biophys, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Physiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Psychobiol, Sao Paulo, BrazilWeb of Science605-613engAcad Sciences Czech Republic, Inst PhysiologyPhysiological ResearchIntense exerciseHPA axisBody composition adrenal glandsThymusGastrocnemius muscleActivation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Miceinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/451032021-09-29 11:28:07.551metadata only accessoai:repositorio.unifesp.br:11600/45103Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-09-29T14:28:07Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
title |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
spellingShingle |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice Rosa, Eloi Francisco [UNIFESP] Intense exercise HPA axis Body composition adrenal glands Thymus Gastrocnemius muscle |
title_short |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
title_full |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
title_fullStr |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
title_full_unstemmed |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
title_sort |
Activation of HPA Axis and Remodeling of Body Chemical Composition in Response to an Intense and Exhaustive Exercise in C57BL/6 Mice |
author |
Rosa, Eloi Francisco [UNIFESP] |
author_facet |
Rosa, Eloi Francisco [UNIFESP] Alves, Gabriel Andrade [UNIFESP] Luz, Jacqueline [UNIFESP] Silva, Sylvia Maria Affonso da [UNIFESP] Suchecki, Deborah [UNIFESP] Pesquero, João Bosco [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Nouailhetas, Viviane Louise Andree [UNIFESP] |
author_role |
author |
author2 |
Alves, Gabriel Andrade [UNIFESP] Luz, Jacqueline [UNIFESP] Silva, Sylvia Maria Affonso da [UNIFESP] Suchecki, Deborah [UNIFESP] Pesquero, João Bosco [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Nouailhetas, Viviane Louise Andree [UNIFESP] |
author2_role |
author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Univ Santo Amaro |
dc.contributor.author.fl_str_mv |
Rosa, Eloi Francisco [UNIFESP] Alves, Gabriel Andrade [UNIFESP] Luz, Jacqueline [UNIFESP] Silva, Sylvia Maria Affonso da [UNIFESP] Suchecki, Deborah [UNIFESP] Pesquero, João Bosco [UNIFESP] Aboulafia, Jeannine [UNIFESP] Nouailhetas, Nouailhetas, Viviane Louise Andree [UNIFESP] |
dc.subject.eng.fl_str_mv |
Intense exercise HPA axis Body composition adrenal glands Thymus Gastrocnemius muscle |
topic |
Intense exercise HPA axis Body composition adrenal glands Thymus Gastrocnemius muscle |
description |
Several deleterious effects may occur when intense and exhaustive exercise (IE) is not well-planned. This study aimed to investigate the effects of a short duration IE on body chemical composition and hypothalamic-pituitary-adrenal (HPA) axis. C57Bl/6 mice were distributed into four groups (10 mice per group): control (C-4D and C-10D), 4 days (E-4D), and 10 days of IE (E-10D). IE program consisted of a daily running session at 85 % of maximum speed until the animal reached exhaustion. Body weight as well as total body water, fat and protein content were determined from animal carcasses. HPA activation was assessed by plasma corticosterone levels measured by radioimmunoassay and the weight of both the adrenal glands and thymus were measured. Plasma corticosterone levels increased by 64 % in both the E-4D and E-10D groups. The weight of the adrenal glands augmented by 74 % and 45 %, at 4 and 10 days of IE, respectively, whereas thymus weight diminished by 15 % only in the E-10D group. The total carcass fat content decreased by 20 % only at 4 days IE, whereas protein content decreased by 20 % in both E-4D and E-10D groups. A relationship between corticosterone plasma levels and loss of body protein content in both E-4D and E-10D groups was observed (R-2=0.999). We concluded that IE may be related to HPA axis activation associated with remodeling of body chemical composition in C57BL/6 mice. |
publishDate |
2014 |
dc.date.issued.fl_str_mv |
2014-01-01 |
dc.date.accessioned.fl_str_mv |
2018-06-18T11:27:05Z |
dc.date.available.fl_str_mv |
2018-06-18T11:27:05Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 63, n. 5, p. 605-613, 2014. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/45103 http://www.biomed.cas.cz/physiolres/pdf/63/63_605.pdf |
dc.identifier.issn.none.fl_str_mv |
0862-8408 |
dc.identifier.wos.none.fl_str_mv |
WOS:000345590100011 |
identifier_str_mv |
Physiological Research. Prague 4: Acad Sciences Czech Republic, Inst Physiology, v. 63, n. 5, p. 605-613, 2014. 0862-8408 WOS:000345590100011 |
url |
http://repositorio.unifesp.br/11600/45103 http://www.biomed.cas.cz/physiolres/pdf/63/63_605.pdf |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Physiological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
605-613 |
dc.publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
publisher.none.fl_str_mv |
Acad Sciences Czech Republic, Inst Physiology |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764143344746496 |