Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
Autor(a) principal: | |
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Data de Publicação: | 2011 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/S1984-82502011000400020 http://repositorio.unifesp.br/handle/11600/6726 |
Resumo: | Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism. |
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Memory retrieval improvement by Heteropterys aphrodisiaca in aging ratsHeteropterys aphrodisiaca O. MachMalpighiaceaeAntioxidantsFlavonoidsPlant extractHeteropterys aphrodisiaca O. MachMalpighiaceaeAntioxidantesFlavonóidesExtrato vegetalFew data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism.Existem poucos dados disponíveis sobre as propriedades farmacológicas da Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), nativa da região do pantanal brasileiro. O presente estudo investigou o efeito do tratamento oral com um extrato de H. aphrodisiaca (BST0298) sobre a memória e aprendizagem de ratos jovens (3-6 meses) e idosos (21-23 meses) e comparou a atividade antioxidante in vitro de três lotes, coletados em diferentes anos. Melhora quanto ao número de sessões necessárias para aprender a tarefa foi observada no teste de discriminação direita/esquerda em ratos idosos tratados por 45 dias com doses de 25 mg/kg (7,0 ± 0,5; p=0,005) e 50 mg/kg (7,6 ± 0,6; p=0,012) comparados com ratos idosos controle (11,0 ± 1,6). Por outro lado, o pré-tratamento com o extrato não melhorou o desempenho de camundongos tratados com escopolamina no teste da esquiva passiva. Em relação à avaliação da atividade antioxidante in vitro pelo teste do malonodialdeído, os três lotes analisados apresentaram atividade antioxidante semelhante. Os flavonóides astilbina, isoastilbina e neoastilbina foram isolados do extrato e podem contribuir para a atividade biológica. Estes resultados sugerem que a administração repetida de H. aphrodisiaca melhora a memória e aprendizagem provavelmente por um mecanismo não muscarínico.Universidade Estadual do Piauí Center for Health SciencesUniversidade Federal do ABC Center of Natural Sciences and HumanitiesUniversidade Federal de São Paulo (UNIFESP) Department of PsychobiologyUniversidade Estadual de Maringá Department of PharmacyUniversidade Comunitária Regional de Chapecó Laboratory of PharmacognosyUNIFESP, Department of PsychobiologySciELOUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasUniversidade Estadual do Piauí Center for Health SciencesUniversidade Federal do ABC Center of Natural Sciences and HumanitiesUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual de Maringá Department of PharmacyUniversidade Comunitária Regional de Chapecó Laboratory of PharmacognosyGalvao, Suzana Maria Pereira [UNIFESP]Mendes, Fúlvio Rieli [UNIFESP]Oliveira, Maria Gabriela Menezes de [UNIFESP]Mattei, Rita [UNIFESP]Mello, João Carlos Palazzo deRoman Júnior, Walter AntonioCarlini, Elisaldo Araujo [UNIFESP]2015-06-14T13:43:23Z2015-06-14T13:43:23Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion825-832application/pdfhttp://dx.doi.org/10.1590/S1984-82502011000400020Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011.10.1590/S1984-82502011000400020S1984-82502011000400020.pdf1984-8250S1984-82502011000400020http://repositorio.unifesp.br/handle/11600/6726WOS:000302521000020engBrazilian Journal of Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T12:22:41Zoai:repositorio.unifesp.br/:11600/6726Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T12:22:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
title |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
spellingShingle |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats Galvao, Suzana Maria Pereira [UNIFESP] Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidants Flavonoids Plant extract Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidantes Flavonóides Extrato vegetal |
title_short |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
title_full |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
title_fullStr |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
title_full_unstemmed |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
title_sort |
Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats |
author |
Galvao, Suzana Maria Pereira [UNIFESP] |
author_facet |
Galvao, Suzana Maria Pereira [UNIFESP] Mendes, Fúlvio Rieli [UNIFESP] Oliveira, Maria Gabriela Menezes de [UNIFESP] Mattei, Rita [UNIFESP] Mello, João Carlos Palazzo de Roman Júnior, Walter Antonio Carlini, Elisaldo Araujo [UNIFESP] |
author_role |
author |
author2 |
Mendes, Fúlvio Rieli [UNIFESP] Oliveira, Maria Gabriela Menezes de [UNIFESP] Mattei, Rita [UNIFESP] Mello, João Carlos Palazzo de Roman Júnior, Walter Antonio Carlini, Elisaldo Araujo [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.none.fl_str_mv |
Universidade Estadual do Piauí Center for Health Sciences Universidade Federal do ABC Center of Natural Sciences and Humanities Universidade Federal de São Paulo (UNIFESP) Universidade Estadual de Maringá Department of Pharmacy Universidade Comunitária Regional de Chapecó Laboratory of Pharmacognosy |
dc.contributor.author.fl_str_mv |
Galvao, Suzana Maria Pereira [UNIFESP] Mendes, Fúlvio Rieli [UNIFESP] Oliveira, Maria Gabriela Menezes de [UNIFESP] Mattei, Rita [UNIFESP] Mello, João Carlos Palazzo de Roman Júnior, Walter Antonio Carlini, Elisaldo Araujo [UNIFESP] |
dc.subject.por.fl_str_mv |
Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidants Flavonoids Plant extract Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidantes Flavonóides Extrato vegetal |
topic |
Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidants Flavonoids Plant extract Heteropterys aphrodisiaca O. Mach Malpighiaceae Antioxidantes Flavonóides Extrato vegetal |
description |
Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism. |
publishDate |
2011 |
dc.date.none.fl_str_mv |
2011-12-01 2015-06-14T13:43:23Z 2015-06-14T13:43:23Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1984-82502011000400020 Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011. 10.1590/S1984-82502011000400020 S1984-82502011000400020.pdf 1984-8250 S1984-82502011000400020 http://repositorio.unifesp.br/handle/11600/6726 WOS:000302521000020 |
url |
http://dx.doi.org/10.1590/S1984-82502011000400020 http://repositorio.unifesp.br/handle/11600/6726 |
identifier_str_mv |
Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011. 10.1590/S1984-82502011000400020 S1984-82502011000400020.pdf 1984-8250 S1984-82502011000400020 WOS:000302521000020 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
Brazilian Journal of Pharmaceutical Sciences |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
825-832 application/pdf |
dc.publisher.none.fl_str_mv |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
publisher.none.fl_str_mv |
Universidade de São Paulo, Faculdade de Ciências Farmacêuticas |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268392728690688 |