Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats

Detalhes bibliográficos
Autor(a) principal: Galvao, Suzana Maria Pereira [UNIFESP]
Data de Publicação: 2011
Outros Autores: Mendes, Fúlvio Rieli [UNIFESP], Oliveira, Maria Gabriela Menezes de [UNIFESP], Mattei, Rita [UNIFESP], Mello, João Carlos Palazzo de, Roman Júnior, Walter Antonio, Carlini, Elisaldo Araujo [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S1984-82502011000400020
http://repositorio.unifesp.br/handle/11600/6726
Resumo: Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism.
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spelling Memory retrieval improvement by Heteropterys aphrodisiaca in aging ratsHeteropterys aphrodisiaca O. MachMalpighiaceaeAntioxidantsFlavonoidsPlant extractHeteropterys aphrodisiaca O. MachMalpighiaceaeAntioxidantesFlavonóidesExtrato vegetalFew data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism.Existem poucos dados disponíveis sobre as propriedades farmacológicas da Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), nativa da região do pantanal brasileiro. O presente estudo investigou o efeito do tratamento oral com um extrato de H. aphrodisiaca (BST0298) sobre a memória e aprendizagem de ratos jovens (3-6 meses) e idosos (21-23 meses) e comparou a atividade antioxidante in vitro de três lotes, coletados em diferentes anos. Melhora quanto ao número de sessões necessárias para aprender a tarefa foi observada no teste de discriminação direita/esquerda em ratos idosos tratados por 45 dias com doses de 25 mg/kg (7,0 ± 0,5; p=0,005) e 50 mg/kg (7,6 ± 0,6; p=0,012) comparados com ratos idosos controle (11,0 ± 1,6). Por outro lado, o pré-tratamento com o extrato não melhorou o desempenho de camundongos tratados com escopolamina no teste da esquiva passiva. Em relação à avaliação da atividade antioxidante in vitro pelo teste do malonodialdeído, os três lotes analisados apresentaram atividade antioxidante semelhante. Os flavonóides astilbina, isoastilbina e neoastilbina foram isolados do extrato e podem contribuir para a atividade biológica. Estes resultados sugerem que a administração repetida de H. aphrodisiaca melhora a memória e aprendizagem provavelmente por um mecanismo não muscarínico.Universidade Estadual do Piauí Center for Health SciencesUniversidade Federal do ABC Center of Natural Sciences and HumanitiesUniversidade Federal de São Paulo (UNIFESP) Department of PsychobiologyUniversidade Estadual de Maringá Department of PharmacyUniversidade Comunitária Regional de Chapecó Laboratory of PharmacognosyUNIFESP, Department of PsychobiologySciELOUniversidade de São Paulo, Faculdade de Ciências FarmacêuticasUniversidade Estadual do Piauí Center for Health SciencesUniversidade Federal do ABC Center of Natural Sciences and HumanitiesUniversidade Federal de São Paulo (UNIFESP)Universidade Estadual de Maringá Department of PharmacyUniversidade Comunitária Regional de Chapecó Laboratory of PharmacognosyGalvao, Suzana Maria Pereira [UNIFESP]Mendes, Fúlvio Rieli [UNIFESP]Oliveira, Maria Gabriela Menezes de [UNIFESP]Mattei, Rita [UNIFESP]Mello, João Carlos Palazzo deRoman Júnior, Walter AntonioCarlini, Elisaldo Araujo [UNIFESP]2015-06-14T13:43:23Z2015-06-14T13:43:23Z2011-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion825-832application/pdfhttp://dx.doi.org/10.1590/S1984-82502011000400020Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011.10.1590/S1984-82502011000400020S1984-82502011000400020.pdf1984-8250S1984-82502011000400020http://repositorio.unifesp.br/handle/11600/6726WOS:000302521000020engBrazilian Journal of Pharmaceutical Sciencesinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-30T12:22:41Zoai:repositorio.unifesp.br/:11600/6726Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-30T12:22:41Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
title Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
spellingShingle Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
Galvao, Suzana Maria Pereira [UNIFESP]
Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidants
Flavonoids
Plant extract
Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidantes
Flavonóides
Extrato vegetal
title_short Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
title_full Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
title_fullStr Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
title_full_unstemmed Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
title_sort Memory retrieval improvement by Heteropterys aphrodisiaca in aging rats
author Galvao, Suzana Maria Pereira [UNIFESP]
author_facet Galvao, Suzana Maria Pereira [UNIFESP]
Mendes, Fúlvio Rieli [UNIFESP]
Oliveira, Maria Gabriela Menezes de [UNIFESP]
Mattei, Rita [UNIFESP]
Mello, João Carlos Palazzo de
Roman Júnior, Walter Antonio
Carlini, Elisaldo Araujo [UNIFESP]
author_role author
author2 Mendes, Fúlvio Rieli [UNIFESP]
Oliveira, Maria Gabriela Menezes de [UNIFESP]
Mattei, Rita [UNIFESP]
Mello, João Carlos Palazzo de
Roman Júnior, Walter Antonio
Carlini, Elisaldo Araujo [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual do Piauí Center for Health Sciences
Universidade Federal do ABC Center of Natural Sciences and Humanities
Universidade Federal de São Paulo (UNIFESP)
Universidade Estadual de Maringá Department of Pharmacy
Universidade Comunitária Regional de Chapecó Laboratory of Pharmacognosy
dc.contributor.author.fl_str_mv Galvao, Suzana Maria Pereira [UNIFESP]
Mendes, Fúlvio Rieli [UNIFESP]
Oliveira, Maria Gabriela Menezes de [UNIFESP]
Mattei, Rita [UNIFESP]
Mello, João Carlos Palazzo de
Roman Júnior, Walter Antonio
Carlini, Elisaldo Araujo [UNIFESP]
dc.subject.por.fl_str_mv Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidants
Flavonoids
Plant extract
Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidantes
Flavonóides
Extrato vegetal
topic Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidants
Flavonoids
Plant extract
Heteropterys aphrodisiaca O. Mach
Malpighiaceae
Antioxidantes
Flavonóides
Extrato vegetal
description Few data exists about the pharmacological properties of Heteropterys aphrodisiaca O. Mach. (Malpighiaceae), which is native to the scrubland regions of Brazil. The present study investigated the effects of oral treatment with H. aphrodisiaca extract (BST0298) on the learning and memory of young (3-6 months) and aged (21-23 months) rats, and compared the in vitro antioxidant activity of three lots collected in different years. An improvement in the number of sessions to learn the task was observed in the left/right discrimination test in aged rats treated for 45 days with 25 mg/kg (7.0 ± 0.5; p=0.005) or 50 mg/kg (7.6 ± 0.6; p=0.012) compared with control old rats (11.0 ± 1.6). On the other hand, pre-treatment did not improve the performance of scopolamine-treated mice in the passive avoidance test. The in vitro malondialdehyde test showed that all three different extracts presented similar antioxidant activity. The flavonoids astilbin, isoastilbin and neoastilbin were isolated from the extract and may contribute to the biological activity. These results suggest that repeated treatment with H. aphrodisiaca improves learning and memory, probably by a non-muscarinic mechanism.
publishDate 2011
dc.date.none.fl_str_mv 2011-12-01
2015-06-14T13:43:23Z
2015-06-14T13:43:23Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S1984-82502011000400020
Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011.
10.1590/S1984-82502011000400020
S1984-82502011000400020.pdf
1984-8250
S1984-82502011000400020
http://repositorio.unifesp.br/handle/11600/6726
WOS:000302521000020
url http://dx.doi.org/10.1590/S1984-82502011000400020
http://repositorio.unifesp.br/handle/11600/6726
identifier_str_mv Brazilian Journal of Pharmaceutical Sciences. Universidade de São Paulo, Faculdade de Ciências Farmacêuticas, v. 47, n. 4, p. 825-832, 2011.
10.1590/S1984-82502011000400020
S1984-82502011000400020.pdf
1984-8250
S1984-82502011000400020
WOS:000302521000020
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Brazilian Journal of Pharmaceutical Sciences
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 825-832
application/pdf
dc.publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
publisher.none.fl_str_mv Universidade de São Paulo, Faculdade de Ciências Farmacêuticas
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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