Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)

Detalhes bibliográficos
Autor(a) principal: Freitas, Karine Moura de
Data de Publicação: 2012
Outros Autores: Monteiro, Juliana Castro, Gomes, Marcos de Lucca Moreira, Taboga, Sebastião Roberto [UNESP], Dolder, Heidi
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNESP
Texto Completo: http://www.academicjournals.org/journal/JMPR/article-abstract/30BB2E022671
http://hdl.handle.net/11449/122567
Resumo: Heteropterys tomentosa is a Brazilian plant traditionally used as an aphrodisiac and stimulant. Previous studies suggested possible androgenic and antioxidant effects after long term administration of H. tomentosa infusion. The aim of the present study was to evaluate the effects of this plant infusion on the rat ventral prostate: an androgen responsive organ. Wistar rats were treated, by gavage, with H. tomentosa roots infusion (treated group, n=6) or water (control group, n=6) for 56 days. Morphological, morphometrical and stereological analyses were employed to study the ventral prostate tissue, as well as androgen receptor and apoptotic cell staining. The ultrastructure of the prostatic epithelium was also analyzed. No alteration was observed in the stereological and morphometrical analyses. The pattern of androgen receptor expression and the apoptotic index were identical in the control and treated group. Ultrastructural analysis showed no alterations caused by H. tomentosa. These results suggested that treatment with H. tomentosa infusion, although considered a strong aphrodisiac, did not cause any major damage nor benefit to the prostate tissue.
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spelling Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)AphrodisiacHeteropterys aphrodisiacamedicinal plantsphytotherapyreproductionHeteropterys tomentosa is a Brazilian plant traditionally used as an aphrodisiac and stimulant. Previous studies suggested possible androgenic and antioxidant effects after long term administration of H. tomentosa infusion. The aim of the present study was to evaluate the effects of this plant infusion on the rat ventral prostate: an androgen responsive organ. Wistar rats were treated, by gavage, with H. tomentosa roots infusion (treated group, n=6) or water (control group, n=6) for 56 days. Morphological, morphometrical and stereological analyses were employed to study the ventral prostate tissue, as well as androgen receptor and apoptotic cell staining. The ultrastructure of the prostatic epithelium was also analyzed. No alteration was observed in the stereological and morphometrical analyses. The pattern of androgen receptor expression and the apoptotic index were identical in the control and treated group. Ultrastructural analysis showed no alterations caused by H. tomentosa. These results suggested that treatment with H. tomentosa infusion, although considered a strong aphrodisiac, did not cause any major damage nor benefit to the prostate tissue.Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio Preto, Sao Jose do Rio Preto, Rua Cristovão Colombo 2265, Jardim Nazareth, CEP 15054-000, SP, BrasilUniversidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Biologia, Instituto de Biociências Letras e Ciências Exatas de São José do Rio PretoUniversidade Estadual de Campinas (UNICAMP)Universidade Federal do Espírito Santo (UFES)Universidade Estadual Paulista (Unesp)Freitas, Karine Moura deMonteiro, Juliana CastroGomes, Marcos de Lucca MoreiraTaboga, Sebastião Roberto [UNESP]Dolder, Heidi2015-04-27T11:55:52Z2015-04-27T11:55:52Z2012info:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/article5640-5646application/pdfhttp://www.academicjournals.org/journal/JMPR/article-abstract/30BB2E022671Journal of Medicinal Plant Research, v. 6, n. 44, p. 5640-5646, 2012.1996-0875http://hdl.handle.net/11449/12256710.5897/JMPR12.421ISSN1996-0875-2012-06-44-5640-5646.pdf144525946852618824396072956940310000-0002-0970-4288Currículo Lattesreponame:Repositório Institucional da UNESPinstname:Universidade Estadual Paulista (UNESP)instacron:UNESPengJournal of Medicinal Plant Researchinfo:eu-repo/semantics/openAccess2023-10-22T06:08:03Zoai:repositorio.unesp.br:11449/122567Repositório InstitucionalPUBhttp://repositorio.unesp.br/oai/requestopendoar:29462024-08-05T15:37:31.125656Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)false
dc.title.none.fl_str_mv Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
title Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
spellingShingle Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
Freitas, Karine Moura de
Aphrodisiac
Heteropterys aphrodisiaca
medicinal plants
phytotherapy
reproduction
title_short Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
title_full Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
title_fullStr Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
title_full_unstemmed Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
title_sort Study of the ventral prostate of Wistar rats treated with Heteropterys tomentosa (A. Juss.)
author Freitas, Karine Moura de
author_facet Freitas, Karine Moura de
Monteiro, Juliana Castro
Gomes, Marcos de Lucca Moreira
Taboga, Sebastião Roberto [UNESP]
Dolder, Heidi
author_role author
author2 Monteiro, Juliana Castro
Gomes, Marcos de Lucca Moreira
Taboga, Sebastião Roberto [UNESP]
Dolder, Heidi
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Estadual de Campinas (UNICAMP)
Universidade Federal do Espírito Santo (UFES)
Universidade Estadual Paulista (Unesp)
dc.contributor.author.fl_str_mv Freitas, Karine Moura de
Monteiro, Juliana Castro
Gomes, Marcos de Lucca Moreira
Taboga, Sebastião Roberto [UNESP]
Dolder, Heidi
dc.subject.por.fl_str_mv Aphrodisiac
Heteropterys aphrodisiaca
medicinal plants
phytotherapy
reproduction
topic Aphrodisiac
Heteropterys aphrodisiaca
medicinal plants
phytotherapy
reproduction
description Heteropterys tomentosa is a Brazilian plant traditionally used as an aphrodisiac and stimulant. Previous studies suggested possible androgenic and antioxidant effects after long term administration of H. tomentosa infusion. The aim of the present study was to evaluate the effects of this plant infusion on the rat ventral prostate: an androgen responsive organ. Wistar rats were treated, by gavage, with H. tomentosa roots infusion (treated group, n=6) or water (control group, n=6) for 56 days. Morphological, morphometrical and stereological analyses were employed to study the ventral prostate tissue, as well as androgen receptor and apoptotic cell staining. The ultrastructure of the prostatic epithelium was also analyzed. No alteration was observed in the stereological and morphometrical analyses. The pattern of androgen receptor expression and the apoptotic index were identical in the control and treated group. Ultrastructural analysis showed no alterations caused by H. tomentosa. These results suggested that treatment with H. tomentosa infusion, although considered a strong aphrodisiac, did not cause any major damage nor benefit to the prostate tissue.
publishDate 2012
dc.date.none.fl_str_mv 2012
2015-04-27T11:55:52Z
2015-04-27T11:55:52Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://www.academicjournals.org/journal/JMPR/article-abstract/30BB2E022671
Journal of Medicinal Plant Research, v. 6, n. 44, p. 5640-5646, 2012.
1996-0875
http://hdl.handle.net/11449/122567
10.5897/JMPR12.421
ISSN1996-0875-2012-06-44-5640-5646.pdf
1445259468526188
2439607295694031
0000-0002-0970-4288
url http://www.academicjournals.org/journal/JMPR/article-abstract/30BB2E022671
http://hdl.handle.net/11449/122567
identifier_str_mv Journal of Medicinal Plant Research, v. 6, n. 44, p. 5640-5646, 2012.
1996-0875
10.5897/JMPR12.421
ISSN1996-0875-2012-06-44-5640-5646.pdf
1445259468526188
2439607295694031
0000-0002-0970-4288
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Journal of Medicinal Plant Research
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 5640-5646
application/pdf
dc.source.none.fl_str_mv Currículo Lattes
reponame:Repositório Institucional da UNESP
instname:Universidade Estadual Paulista (UNESP)
instacron:UNESP
instname_str Universidade Estadual Paulista (UNESP)
instacron_str UNESP
institution UNESP
reponame_str Repositório Institucional da UNESP
collection Repositório Institucional da UNESP
repository.name.fl_str_mv Repositório Institucional da UNESP - Universidade Estadual Paulista (UNESP)
repository.mail.fl_str_mv
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