Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics
Autor(a) principal: | |
---|---|
Data de Publicação: | 2017 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://dx.doi.org/10.1590/abd1806-4841.2017279 http://repositorio.unifesp.br/handle/11600/51239 |
Resumo: | In the late 90' s there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S. brasiliensis, compared to the environmental isolates. Likewise, different species of Sporothrix have been associated with different geographic regions. The serological and molecular techniques are used as an auxiliary tool for the diagnosis and/or for species identification, although the isolation and the identification of Sporothrix spp. in clinical specimen is still the gold standard. Currently sporotrichosis epidemics requires the knowledge of the epidemiological-molecular profile to control the disease and the specific treatment. Itraconazole, potassium iodide, terfinafine, and amphotericin B are the available drugs in Brazil to treat sporotrichosis. The drug of choice, its posology, and treatment duration vary according to the clinical presentation, the Sporothrix species, and host immune status. New treatment choices, including a vaccine, are being developed |
id |
UFSP_2d31467043c99bdfaa2b3ce8d0717c3a |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br/:11600/51239 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeuticsDiagnosisEpidemiologyMolecular biologySerologySporothrixTherapeuticsIn the late 90' s there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S. brasiliensis, compared to the environmental isolates. Likewise, different species of Sporothrix have been associated with different geographic regions. The serological and molecular techniques are used as an auxiliary tool for the diagnosis and/or for species identification, although the isolation and the identification of Sporothrix spp. in clinical specimen is still the gold standard. Currently sporotrichosis epidemics requires the knowledge of the epidemiological-molecular profile to control the disease and the specific treatment. Itraconazole, potassium iodide, terfinafine, and amphotericin B are the available drugs in Brazil to treat sporotrichosis. The drug of choice, its posology, and treatment duration vary according to the clinical presentation, the Sporothrix species, and host immune status. New treatment choices, including a vaccine, are being developednevertheless, more clinical trials are required to confirm its efficacy.Univ Estado Rio De Janeiro, FCM, Dermatol Dept, Rio De Janeiro, RJ, BrazilFundação Oswaldo Cruz INI Fiocruz, Infect Dermatol Clin Res Lab, Inst Nacl Infectol Evandro Chagas, Rio De Janeiro, RJ, BrazilUniv Fed São Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Lab Emerging Fungal Pathogen, São Paulo, SP, BrazilHosp Univ Pedro Ernesto, Med Mycol Lab, Dermatol Dept, Rio De Janeiro, RJ, BrazilUniv Fed São Paulo UNIFESP, Dept Microbiol Immunol & Parasitol, Lab Emerging Fungal Pathogen, São Paulo, SP, BrazilWeb of ScienceSoc Brasileira Dermatologia2019-08-19T11:48:22Z2019-08-19T11:48:22Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion606-618application/pdfhttp://dx.doi.org/10.1590/abd1806-4841.2017279Anais Brasileiros De Dermatologia. Rio De Janeiro Rj, v. 92, n. 5, p. 606-618, 2017.10.1590/abd1806-4841.2017279WOS000416001300001.pdf0365-0596S0365-05962017000500606http://repositorio.unifesp.br/handle/11600/51239WOS:000416001300001enginfo:eu-repo/semantics/openAccessOrofino-Costa, Rosanede Macedo, Priscila MarquesRodrigues, Anderson Messias [UNIFESP]Bernardes-Engemann, Andrea Reisreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-02T23:37:25Zoai:repositorio.unifesp.br/:11600/51239Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-08-02T23:37:25Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.none.fl_str_mv |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
title |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
spellingShingle |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics Orofino-Costa, Rosane Diagnosis Epidemiology Molecular biology Serology Sporothrix Therapeutics |
title_short |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
title_full |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
title_fullStr |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
title_full_unstemmed |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
title_sort |
Sporotrichosis: an update on epidemiology, etiopathogenesis, laboratory and clinical therapeutics |
author |
Orofino-Costa, Rosane |
author_facet |
Orofino-Costa, Rosane de Macedo, Priscila Marques Rodrigues, Anderson Messias [UNIFESP] Bernardes-Engemann, Andrea Reis |
author_role |
author |
author2 |
de Macedo, Priscila Marques Rodrigues, Anderson Messias [UNIFESP] Bernardes-Engemann, Andrea Reis |
author2_role |
author author author |
dc.contributor.author.fl_str_mv |
Orofino-Costa, Rosane de Macedo, Priscila Marques Rodrigues, Anderson Messias [UNIFESP] Bernardes-Engemann, Andrea Reis |
dc.subject.por.fl_str_mv |
Diagnosis Epidemiology Molecular biology Serology Sporothrix Therapeutics |
topic |
Diagnosis Epidemiology Molecular biology Serology Sporothrix Therapeutics |
description |
In the late 90' s there was a change in both the route of transmission and the people at risk for sporotrichosis. This zoonotic cat-man alternative transmission route elicited changes in strategies to control the epidemic. There was a progressive increase in the number of cases involving especially children and the elderly. In addition to becoming hyperendemic, uncommon clinical pictures like immunoreactive clinical presentations or severe systemic cases have emerged. New species were identified and classified through molecular tools using more virulent clinical isolates, like S. brasiliensis, compared to the environmental isolates. Likewise, different species of Sporothrix have been associated with different geographic regions. The serological and molecular techniques are used as an auxiliary tool for the diagnosis and/or for species identification, although the isolation and the identification of Sporothrix spp. in clinical specimen is still the gold standard. Currently sporotrichosis epidemics requires the knowledge of the epidemiological-molecular profile to control the disease and the specific treatment. Itraconazole, potassium iodide, terfinafine, and amphotericin B are the available drugs in Brazil to treat sporotrichosis. The drug of choice, its posology, and treatment duration vary according to the clinical presentation, the Sporothrix species, and host immune status. New treatment choices, including a vaccine, are being developed |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017 2019-08-19T11:48:22Z 2019-08-19T11:48:22Z |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
format |
article |
status_str |
publishedVersion |
dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/abd1806-4841.2017279 Anais Brasileiros De Dermatologia. Rio De Janeiro Rj, v. 92, n. 5, p. 606-618, 2017. 10.1590/abd1806-4841.2017279 WOS000416001300001.pdf 0365-0596 S0365-05962017000500606 http://repositorio.unifesp.br/handle/11600/51239 WOS:000416001300001 |
url |
http://dx.doi.org/10.1590/abd1806-4841.2017279 http://repositorio.unifesp.br/handle/11600/51239 |
identifier_str_mv |
Anais Brasileiros De Dermatologia. Rio De Janeiro Rj, v. 92, n. 5, p. 606-618, 2017. 10.1590/abd1806-4841.2017279 WOS000416001300001.pdf 0365-0596 S0365-05962017000500606 WOS:000416001300001 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
606-618 application/pdf |
dc.publisher.none.fl_str_mv |
Soc Brasileira Dermatologia |
publisher.none.fl_str_mv |
Soc Brasileira Dermatologia |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
biblioteca.csp@unifesp.br |
_version_ |
1814268403375931392 |