Immune development in HIV-exposed uninfected children born to HIV-infected women
| Autor(a) principal: | |
|---|---|
| Data de Publicação: | 2017 |
| Outros Autores: | , , , , |
| Tipo de documento: | Artigo |
| Idioma: | eng |
| Título da fonte: | Repositório Institucional da UNIFESP |
| dARK ID: | ark:/48912/0013000000cz8 |
| DOI: | 10.1590/S1678-9946201759030 |
| Texto Completo: | http://dx.doi.org/10.1590/S1678-9946201759030 https://repositorio.unifesp.br/handle/11600/56276 |
Resumo: | Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years |
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Immune development in HIV-exposed uninfected children born to HIV-infected womenHIV-exposed uninfectedLymphocyte activationCytokinesLipopolysaccharideCD14 antigenImmunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 yearsfor plasma sCD14, IL-2, IL-6, IL-7, IL-10, IL-12p70, IL-13, IL-17, IFN-gamma, TNF-alpha, G-CSF, GM-CSF and MCP-1, which increased from birth to 12 months and then decreased at 6-12 yearsand for TREC/10(6) PBMC at birth in HEU and controls. By contrast, plasma MIP-1 beta levels were lower in HEU than in controls (p=0.009) at 12 months, and IL-4 levels were higher in HEU than controls (p=0.04) at 6-12 years. Immune activation was higher in HEU at 12 months and at 6-12 years than controls based on frequencies of CD38+HLA-DR+CD8+T cells (p=0.05) and of CD38+HLA-DR+CD4+T cells (p=0.006). Resting memory and activated mature B cells increased from birth to 6-12 years in both groups. The development of the immune system in vertically HEU individuals is comparable to the general population in most parameters, but subtle or transient differences exist. Their role in influencing clinical incidences in HEU is unknown.Univ Fed Sao Paulo, Dept Pediat, Sao Paulo, SP, BrazilUniv Miami, Dept Med, Miami, FL USAUniversidade Federal de São Paulo, Departamento de Pediatria, Divisão de Infectologia Pediátrica, Rua Pedro de Toledo, 781, 9º andar, CEP 04039-032, Vila Clementino, São Paulo, SP, Brazil.Web of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)FAPESP: 10/09701-3FAPESP: 10/09738-4Inst Medicina Tropical Sao Paulo2020-07-31T12:46:33Z2020-07-31T12:46:33Z2017info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion-application/pdfhttp://dx.doi.org/10.1590/S1678-9946201759030Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017.10.1590/S1678-9946201759030S0036-46652017005000217.pdf0036-4665S0036-46652017005000217https://repositorio.unifesp.br/handle/11600/56276WOS:000403274300006ark:/48912/0013000000cz8engRevista Do Instituto De Medicina Tropical De Sao PauloSao Pauloinfo:eu-repo/semantics/openAccessMiyamoto, Maristela [UNIFESP]Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP]Ono, Erika [UNIFESP]Succi, Regina Célia de Menezes [UNIFESP]Pahwa, SavitaMoraes-Pinto, Maria Isabel de [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-08-02T12:38:30Zoai:repositorio.unifesp.br/:11600/56276Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T19:48:23.260182Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
| dc.title.none.fl_str_mv |
Immune development in HIV-exposed uninfected children born to HIV-infected women |
| title |
Immune development in HIV-exposed uninfected children born to HIV-infected women |
| spellingShingle |
Immune development in HIV-exposed uninfected children born to HIV-infected women Immune development in HIV-exposed uninfected children born to HIV-infected women Miyamoto, Maristela [UNIFESP] HIV-exposed uninfected Lymphocyte activation Cytokines Lipopolysaccharide CD14 antigen Miyamoto, Maristela [UNIFESP] HIV-exposed uninfected Lymphocyte activation Cytokines Lipopolysaccharide CD14 antigen |
| title_short |
Immune development in HIV-exposed uninfected children born to HIV-infected women |
| title_full |
Immune development in HIV-exposed uninfected children born to HIV-infected women |
| title_fullStr |
Immune development in HIV-exposed uninfected children born to HIV-infected women Immune development in HIV-exposed uninfected children born to HIV-infected women |
| title_full_unstemmed |
Immune development in HIV-exposed uninfected children born to HIV-infected women Immune development in HIV-exposed uninfected children born to HIV-infected women |
| title_sort |
Immune development in HIV-exposed uninfected children born to HIV-infected women |
| author |
Miyamoto, Maristela [UNIFESP] |
| author_facet |
Miyamoto, Maristela [UNIFESP] Miyamoto, Maristela [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Ono, Erika [UNIFESP] Succi, Regina Célia de Menezes [UNIFESP] Pahwa, Savita Moraes-Pinto, Maria Isabel de [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Ono, Erika [UNIFESP] Succi, Regina Célia de Menezes [UNIFESP] Pahwa, Savita Moraes-Pinto, Maria Isabel de [UNIFESP] |
| author_role |
author |
| author2 |
Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Ono, Erika [UNIFESP] Succi, Regina Célia de Menezes [UNIFESP] Pahwa, Savita Moraes-Pinto, Maria Isabel de [UNIFESP] |
| author2_role |
author author author author author |
| dc.contributor.author.fl_str_mv |
Miyamoto, Maristela [UNIFESP] Gouvêa, Aida de Fátima Thomé Barbosa [UNIFESP] Ono, Erika [UNIFESP] Succi, Regina Célia de Menezes [UNIFESP] Pahwa, Savita Moraes-Pinto, Maria Isabel de [UNIFESP] |
| dc.subject.por.fl_str_mv |
HIV-exposed uninfected Lymphocyte activation Cytokines Lipopolysaccharide CD14 antigen |
| topic |
HIV-exposed uninfected Lymphocyte activation Cytokines Lipopolysaccharide CD14 antigen |
| description |
Immunological and clinical findings suggestive of some immune dysfunction have been reported among HIV-exposed uninfected(HEU) children and adolescents. Whether these defects are persistent or transitory is still unknown. HEU pediatric population at birth, 12 months, 6-12 years were evaluated in comparison to healthy age-matched HIV-unexposed controls. Plasma levels of LPS, sCD14, cytokines, lymphocyte immunophenotyping and T-cell receptor excision circles (TREC) were assessed. HEU and controls had similar LPS levels, which remained low from birth to 6-12 years |
| publishDate |
2017 |
| dc.date.none.fl_str_mv |
2017 2020-07-31T12:46:33Z 2020-07-31T12:46:33Z |
| dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
| dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
| format |
article |
| status_str |
publishedVersion |
| dc.identifier.uri.fl_str_mv |
http://dx.doi.org/10.1590/S1678-9946201759030 Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. 10.1590/S1678-9946201759030 S0036-46652017005000217.pdf 0036-4665 S0036-46652017005000217 https://repositorio.unifesp.br/handle/11600/56276 WOS:000403274300006 |
| dc.identifier.dark.fl_str_mv |
ark:/48912/0013000000cz8 |
| url |
http://dx.doi.org/10.1590/S1678-9946201759030 https://repositorio.unifesp.br/handle/11600/56276 |
| identifier_str_mv |
Revista Do Instituto De Medicina Tropical De Sao Paulo. Sao Paulo, v. 59, p. -, 2017. 10.1590/S1678-9946201759030 S0036-46652017005000217.pdf 0036-4665 S0036-46652017005000217 WOS:000403274300006 ark:/48912/0013000000cz8 |
| dc.language.iso.fl_str_mv |
eng |
| language |
eng |
| dc.relation.none.fl_str_mv |
Revista Do Instituto De Medicina Tropical De Sao Paulo |
| dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
| eu_rights_str_mv |
openAccess |
| dc.format.none.fl_str_mv |
- application/pdf |
| dc.coverage.none.fl_str_mv |
Sao Paulo |
| dc.publisher.none.fl_str_mv |
Inst Medicina Tropical Sao Paulo |
| publisher.none.fl_str_mv |
Inst Medicina Tropical Sao Paulo |
| dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
| instname_str |
Universidade Federal de São Paulo (UNIFESP) |
| instacron_str |
UNIFESP |
| institution |
UNIFESP |
| reponame_str |
Repositório Institucional da UNIFESP |
| collection |
Repositório Institucional da UNIFESP |
| repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
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biblioteca.csp@unifesp.br |
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1822219252947484672 |
| dc.identifier.doi.none.fl_str_mv |
10.1590/S1678-9946201759030 |