Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia
Autor(a) principal: | |
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Data de Publicação: | 1996 |
Outros Autores: | , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/11600/42807 http://dx.doi.org/10.1080/15216549600201202 |
Resumo: | Aspects of the lipid metabolism of Walker 256 carcinosarcoma-bearing cachectic rats (TB) were investigated during a 14 day interval of tumour growth. Food intake and body weight of the TB rats were reduced by 18 % and 13 %, respectively, on day 14, as compared with non-tumour-bearing animals. The tumour burden then, corresponded to 19 % of total body weight. The total fat content was not different in the liver, heart, carcass, epididymal (EAT) and retroperitoneal (RPAT) adipose tissues of the two groups. The brown adipose tissue (BAT) and skeletal muscle (gastrocnemius-SM) of the TB rats had increased levels of fat (23 % and 200 %, respectively). Enteral absorption of C-14-triolein was decreased in the TB rats, but the liver, heart, and SM of these animals incorporated more radiolabelled lipid than the control animals, while the adipose tissues exhibited a decreased incorporation of radioactivity in relation to controls. More lipid was incorporated into the VLDL fraction secreted by the liver of TB rats, which exhibited a different distribution of the incorporated C-14-oleate in the various lipid subfractions. Ultrastructural studies showed that the hepatocytes of the TB rats had a greater incidence of lipid droplets in the cytoplasm. |
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Seelaender, Marilia [UNIFESP]Nascimento, Claudia Maria da Penha Oller do [UNIFESP]Curi, R.Williams, J. F.Universidade de São Paulo (USP)Universidade Federal de São Paulo (UNIFESP)AUSTRALIAN NATL UNIV2018-06-15T14:04:23Z2018-06-15T14:04:23Z1996-08-01Biochemistry And Molecular Biology International. Marrickville: Academic Press Aust, v. 39, n. 5, p. 1037-1047, 1996.1039-9712http://repositorio.unifesp.br/11600/42807http://dx.doi.org/10.1080/1521654960020120210.1080/15216549600201202WOS:A1996VD34200021Aspects of the lipid metabolism of Walker 256 carcinosarcoma-bearing cachectic rats (TB) were investigated during a 14 day interval of tumour growth. Food intake and body weight of the TB rats were reduced by 18 % and 13 %, respectively, on day 14, as compared with non-tumour-bearing animals. The tumour burden then, corresponded to 19 % of total body weight. The total fat content was not different in the liver, heart, carcass, epididymal (EAT) and retroperitoneal (RPAT) adipose tissues of the two groups. The brown adipose tissue (BAT) and skeletal muscle (gastrocnemius-SM) of the TB rats had increased levels of fat (23 % and 200 %, respectively). Enteral absorption of C-14-triolein was decreased in the TB rats, but the liver, heart, and SM of these animals incorporated more radiolabelled lipid than the control animals, while the adipose tissues exhibited a decreased incorporation of radioactivity in relation to controls. More lipid was incorporated into the VLDL fraction secreted by the liver of TB rats, which exhibited a different distribution of the incorporated C-14-oleate in the various lipid subfractions. Ultrastructural studies showed that the hepatocytes of the TB rats had a greater incidence of lipid droplets in the cytoplasm.UNIV SAO PAULO,INST BIOMED SCI,DEPT PHYSIOL & BIOPHYS,BR-05508900 SAO PAULO,BRAZILESCOLA PAULISTA MED,DEPT NEUROENDOCRINE PHYSIOL,SAO PAULO,BRAZILAUSTRALIAN NATL UNIV,RES SCH CHEM,CANBERRA,ACT 2601,AUSTRALIAESCOLA PAULISTA MED,DEPT NEUROENDOCRINE PHYSIOL,SAO PAULO,BRAZILWeb of Science1037-1047engAcademic Press AustBiochemistry And Molecular Biology InternationalStudies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexiainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/428072021-09-30 17:26:57.041metadata only accessoai:repositorio.unifesp.br:11600/42807Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-05-25T12:20:53.514064Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
title |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
spellingShingle |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia Seelaender, Marilia [UNIFESP] |
title_short |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
title_full |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
title_fullStr |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
title_full_unstemmed |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
title_sort |
Studies on the lipid metabolism of Walker 256 tumour-bearing rats during the development of cancer cachexia |
author |
Seelaender, Marilia [UNIFESP] |
author_facet |
Seelaender, Marilia [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Curi, R. Williams, J. F. |
author_role |
author |
author2 |
Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Curi, R. Williams, J. F. |
author2_role |
author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade de São Paulo (USP) Universidade Federal de São Paulo (UNIFESP) AUSTRALIAN NATL UNIV |
dc.contributor.author.fl_str_mv |
Seelaender, Marilia [UNIFESP] Nascimento, Claudia Maria da Penha Oller do [UNIFESP] Curi, R. Williams, J. F. |
description |
Aspects of the lipid metabolism of Walker 256 carcinosarcoma-bearing cachectic rats (TB) were investigated during a 14 day interval of tumour growth. Food intake and body weight of the TB rats were reduced by 18 % and 13 %, respectively, on day 14, as compared with non-tumour-bearing animals. The tumour burden then, corresponded to 19 % of total body weight. The total fat content was not different in the liver, heart, carcass, epididymal (EAT) and retroperitoneal (RPAT) adipose tissues of the two groups. The brown adipose tissue (BAT) and skeletal muscle (gastrocnemius-SM) of the TB rats had increased levels of fat (23 % and 200 %, respectively). Enteral absorption of C-14-triolein was decreased in the TB rats, but the liver, heart, and SM of these animals incorporated more radiolabelled lipid than the control animals, while the adipose tissues exhibited a decreased incorporation of radioactivity in relation to controls. More lipid was incorporated into the VLDL fraction secreted by the liver of TB rats, which exhibited a different distribution of the incorporated C-14-oleate in the various lipid subfractions. Ultrastructural studies showed that the hepatocytes of the TB rats had a greater incidence of lipid droplets in the cytoplasm. |
publishDate |
1996 |
dc.date.issued.fl_str_mv |
1996-08-01 |
dc.date.accessioned.fl_str_mv |
2018-06-15T14:04:23Z |
dc.date.available.fl_str_mv |
2018-06-15T14:04:23Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Biochemistry And Molecular Biology International. Marrickville: Academic Press Aust, v. 39, n. 5, p. 1037-1047, 1996. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/11600/42807 http://dx.doi.org/10.1080/15216549600201202 |
dc.identifier.issn.none.fl_str_mv |
1039-9712 |
dc.identifier.doi.none.fl_str_mv |
10.1080/15216549600201202 |
dc.identifier.wos.none.fl_str_mv |
WOS:A1996VD34200021 |
identifier_str_mv |
Biochemistry And Molecular Biology International. Marrickville: Academic Press Aust, v. 39, n. 5, p. 1037-1047, 1996. 1039-9712 10.1080/15216549600201202 WOS:A1996VD34200021 |
url |
http://repositorio.unifesp.br/11600/42807 http://dx.doi.org/10.1080/15216549600201202 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Biochemistry And Molecular Biology International |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1037-1047 |
dc.publisher.none.fl_str_mv |
Academic Press Aust |
publisher.none.fl_str_mv |
Academic Press Aust |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460279158308864 |