Intestinal metaplasia in gallbladders: prevalence study

• Autor(a) principal: Fernandes, Jose Eduardo Vasconcelos
• Data de Publicação: 2008
• Outros Autores: Franco, Maria Isete Fares, Suzuki, Reinaldo Kenji, Tavares, Nelson Mattos, Bromberg, Sansom Henrique [UNIFESP]
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://dx.doi.org/10.1590/S1516-31802008000400004; http://repositorio.unifesp.br/handle/11600/45542
• topic: Lithiasis; Cholecystitis; Gallbladder; Metaplasia; Cholecystectomy

CONTEXT AND OBJECTIVE: Gallbladder cancer is usually diagnosed at a late stage and generally results in death. Discovery of predisposing factors for this neoplasia could prevent this outcome. In this study, we assess the presence of one of these factors: intestinal metaplasia in gallbladders with stones and inflammatory processes.DESIGN AND SETTING: Cross-sectional study in Hospital do Servidor Publico Estadual de Sao Paulo.METHOD: The first 80 gallbladders from patients who underwent elective cholecystectomy between April and August 2002, presenting stones and chronic inflammation, were studied. The patients were divided into groups according to their age: CC 1, from 15 to 40 years; CC2, from A I to 60 years; and CC3, from 61 to 85 years.RESULTS: Twenty-one patients (26%) were male, while 59 (74%) were female. In the group CC 1, intestinal metaplasia was present in 85.71% of the 21 patients studied; in CC2, in 79.41% of 34 patients; and in CC3, in 56.00% of 25 patients. These differences presented statistical significance (p = 0.04542).CONCLUSION: Intestinal metaplasia is extremely frequent in gallbladders with inflammation and lithiasis, especially in younger patients.