Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model
Autor(a) principal: | |
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Data de Publicação: | 2010 |
Outros Autores: | , , , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/32028 http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x |
Resumo: | P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy. |
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Calcagnotto, Maria E. [UNIFESP]Ruiz, Lorena P. [UNIFESP]Blanco, Miriam M. [UNIFESP]Santos-Junior, Jair G. [UNIFESP]Valente, Maria F. [UNIFESP]Patti, Camila [UNIFESP]Frussa-Filho, Roberto [UNIFESP]Santiago, Marcelo F.Zipancic, IvanAlvarez-Dolado, ManuelMello, Luiz E. [UNIFESP]Longo, Beatriz M. [UNIFESP]Universidade Federal de São Paulo (UNIFESP)Ctr Andaluz Biol Mol & Med Regenerat CABIMERFac Ciencias Med Santa CasaUniversidade Federal do Rio de Janeiro (UFRJ)2016-01-24T13:59:01Z2016-01-24T13:59:01Z2010-01-01Epilepsia. Malden: Wiley-Blackwell, v. 51, p. 71-75, 2010.0013-9580http://repositorio.unifesp.br/handle/11600/32028http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x10.1111/j.1528-1167.2010.02614.xWOS:000279442400014P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy.Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro (FAPERJ)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)Universidade Federal de São Paulo, Dept Fisiol, São Paulo, BrazilCtr Andaluz Biol Mol & Med Regenerat CABIMER, Dept Terapia Celular & Med Regenerat, Seville, SpainFac Ciencias Med Santa Casa, Dept Ciencias Fisiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, BrazilUniv Fed Rio de Janeiro, Inst Biofis Carlos Chagas Filho, BR-21941 Rio de Janeiro, BrazilUniversidade Federal de São Paulo, Dept Fisiol, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Farmacol, São Paulo, BrazilWeb of Science71-75engWiley-BlackwellEpilepsiahttp://olabout.wiley.com/WileyCDA/Section/id-406071.htmlinfo:eu-repo/semantics/openAccessMaximum electroconvulsive shockNeural stem cellsGABAergic cellsTonic seizuresTransplantationEffect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure modelinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articlereponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/320282022-11-04 15:08:28.423metadata only accessoai:repositorio.unifesp.br:11600/32028Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-11-04T18:08:28Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
title |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
spellingShingle |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model Calcagnotto, Maria E. [UNIFESP] Maximum electroconvulsive shock Neural stem cells GABAergic cells Tonic seizures Transplantation |
title_short |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
title_full |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
title_fullStr |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
title_full_unstemmed |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
title_sort |
Effect of neuronal precursor cells derived from medial ganglionic eminence in an acute epileptic seizure model |
author |
Calcagnotto, Maria E. [UNIFESP] |
author_facet |
Calcagnotto, Maria E. [UNIFESP] Ruiz, Lorena P. [UNIFESP] Blanco, Miriam M. [UNIFESP] Santos-Junior, Jair G. [UNIFESP] Valente, Maria F. [UNIFESP] Patti, Camila [UNIFESP] Frussa-Filho, Roberto [UNIFESP] Santiago, Marcelo F. Zipancic, Ivan Alvarez-Dolado, Manuel Mello, Luiz E. [UNIFESP] Longo, Beatriz M. [UNIFESP] |
author_role |
author |
author2 |
Ruiz, Lorena P. [UNIFESP] Blanco, Miriam M. [UNIFESP] Santos-Junior, Jair G. [UNIFESP] Valente, Maria F. [UNIFESP] Patti, Camila [UNIFESP] Frussa-Filho, Roberto [UNIFESP] Santiago, Marcelo F. Zipancic, Ivan Alvarez-Dolado, Manuel Mello, Luiz E. [UNIFESP] Longo, Beatriz M. [UNIFESP] |
author2_role |
author author author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) Ctr Andaluz Biol Mol & Med Regenerat CABIMER Fac Ciencias Med Santa Casa Universidade Federal do Rio de Janeiro (UFRJ) |
dc.contributor.author.fl_str_mv |
Calcagnotto, Maria E. [UNIFESP] Ruiz, Lorena P. [UNIFESP] Blanco, Miriam M. [UNIFESP] Santos-Junior, Jair G. [UNIFESP] Valente, Maria F. [UNIFESP] Patti, Camila [UNIFESP] Frussa-Filho, Roberto [UNIFESP] Santiago, Marcelo F. Zipancic, Ivan Alvarez-Dolado, Manuel Mello, Luiz E. [UNIFESP] Longo, Beatriz M. [UNIFESP] |
dc.subject.eng.fl_str_mv |
Maximum electroconvulsive shock Neural stem cells GABAergic cells Tonic seizures Transplantation |
topic |
Maximum electroconvulsive shock Neural stem cells GABAergic cells Tonic seizures Transplantation |
description |
P>Most of the gamma-aminobutyric acid (GABA)ergic interneurons in the cerebral cortex originate from restricted regions of the ventral telencephalon known as the caudal and medial ganglionic eminence (MGE) and from the preoptic area. It is well established that dysfunction of GABAergic interneurons can lead to epilepsy. During the last decade new approaches to prevent, reduce, or reverse the epileptic condition have been studied, including cell-based therapy from different sources. Recent studies have shown that transplanted neuronal precursor cells derived from MGE have the ability to migrate, differentiate into inhibitory GABAergic interneurons, and integrate into cortical and hippocampal networks, modifying the inhibitory tone in the host brain. Therefore, transplantation of neuronal precursors derived from MGE into the postnatal central nervous system (CNS) could modify the neuronal circuitry in neurologic diseases in which inhibitory synaptic function is altered, such as in epilepsy. Here, we evaluated the seizure susceptibility of mice transplanted with MGE-derived cells in the maximum electroconvulsive shock (MES) model and we review some data from different studies using GABAergic precursor or GABA-releasing cell grafts in animal models of seizure and epilepsy. |
publishDate |
2010 |
dc.date.issued.fl_str_mv |
2010-01-01 |
dc.date.accessioned.fl_str_mv |
2016-01-24T13:59:01Z |
dc.date.available.fl_str_mv |
2016-01-24T13:59:01Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Epilepsia. Malden: Wiley-Blackwell, v. 51, p. 71-75, 2010. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/32028 http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x |
dc.identifier.issn.none.fl_str_mv |
0013-9580 |
dc.identifier.doi.none.fl_str_mv |
10.1111/j.1528-1167.2010.02614.x |
dc.identifier.wos.none.fl_str_mv |
WOS:000279442400014 |
identifier_str_mv |
Epilepsia. Malden: Wiley-Blackwell, v. 51, p. 71-75, 2010. 0013-9580 10.1111/j.1528-1167.2010.02614.x WOS:000279442400014 |
url |
http://repositorio.unifesp.br/handle/11600/32028 http://dx.doi.org/10.1111/j.1528-1167.2010.02614.x |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Epilepsia |
dc.rights.driver.fl_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html info:eu-repo/semantics/openAccess |
rights_invalid_str_mv |
http://olabout.wiley.com/WileyCDA/Section/id-406071.html |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
71-75 |
dc.publisher.none.fl_str_mv |
Wiley-Blackwell |
publisher.none.fl_str_mv |
Wiley-Blackwell |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764184243404800 |