Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos

Detalhes bibliográficos
Autor(a) principal: Santos, Paulo César [UNIFESP]
Data de Publicação: 2002
Outros Autores: Gerola, Luís Roberto [UNIFESP], Pessa, Clodualdo J.N. [UNIFESP], Branco, João Nelson Rodrigues [UNIFESP], Casagrande, Ivan Sergio Joviano, Buffolo, Enio [UNIFESP]
Tipo de documento: Artigo
Idioma: por
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1590/S0102-76382002000100013
http://repositorio.unifesp.br/handle/11600/1379
Resumo: INTRODUCTION: Often, studies on aortic prosthetic valves analyze their performance not at the primitive position, but using tricuspid and mitral ones or inserting it in the descending aortic area. Taking that into account, it would be relevant to observe results in those studies in which the conclusions are based on their original implantation. MATERIAL AND METHODS: Thirty young sheep, 28 males and 2 females, were operated on. Ages ranged 4.4 to 6.3 months and weights 25 to 37 Kg. Extra corporeal circulation (ECC) was applied to all the animals, always guided by the conventional criteria, that is to say, the arterial cannula was inserted in the thoracic aorta just past the arterious ducts and the venous cannulae, a single one, was placed in the right atrium. The operation was performed according to the principle of moderately low body temperature- 29ºC- and cold cristalloid cardioplegia, in the aortic root, to induce; but otherwise was utilized blood to the maintenance. Following with the technique proposed, the aortic valve of the animal heart was completely excised and finally implanted the valved tube stentless, not forgetting the refixation of the coronary main. The sheep were kept in clinical and laboratorial observation during thirty days in what was included a echocardiogram in the end. RESULTS: The results demonstrated 8 intraoperatory deaths (26.6%), and 6 during the following (27.7%). The mean time of ECC was 98 minutes. The dimension of the majority prothetics valves were 21 and 23. Only two valves evoluted with mild insufficiency, none denoted evidences of the endocarditis neither of leaflets perfuration, the mean fraction of ejection was 74%, the left ventricle had its wall preserved in all cases. CONCLUSION: This experimental model can certainly reproduce nearly the reality, confirming good parameters of prothetics stentless evaluation in the aortic position. And the sheep declared itself to be pleasant, which helps us its control during the whole study.
id UFSP_696ae0d16716d81765169bdabd7cb94c
oai_identifier_str oai:repositorio.unifesp.br/:11600/1379
network_acronym_str UFSP
network_name_str Repositório Institucional da UNIFESP
repository_id_str 3465
spelling Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinosA juvenile sheep model for the stentless bioprostheses implanted as aortic root replacementsAortic valveBlood vessel prosthesis, implantationBioprosthesisValva aórticaImplante de prótese vascularBioprótesesINTRODUCTION: Often, studies on aortic prosthetic valves analyze their performance not at the primitive position, but using tricuspid and mitral ones or inserting it in the descending aortic area. Taking that into account, it would be relevant to observe results in those studies in which the conclusions are based on their original implantation. MATERIAL AND METHODS: Thirty young sheep, 28 males and 2 females, were operated on. Ages ranged 4.4 to 6.3 months and weights 25 to 37 Kg. Extra corporeal circulation (ECC) was applied to all the animals, always guided by the conventional criteria, that is to say, the arterial cannula was inserted in the thoracic aorta just past the arterious ducts and the venous cannulae, a single one, was placed in the right atrium. The operation was performed according to the principle of moderately low body temperature- 29ºC- and cold cristalloid cardioplegia, in the aortic root, to induce; but otherwise was utilized blood to the maintenance. Following with the technique proposed, the aortic valve of the animal heart was completely excised and finally implanted the valved tube stentless, not forgetting the refixation of the coronary main. The sheep were kept in clinical and laboratorial observation during thirty days in what was included a echocardiogram in the end. RESULTS: The results demonstrated 8 intraoperatory deaths (26.6%), and 6 during the following (27.7%). The mean time of ECC was 98 minutes. The dimension of the majority prothetics valves were 21 and 23. Only two valves evoluted with mild insufficiency, none denoted evidences of the endocarditis neither of leaflets perfuration, the mean fraction of ejection was 74%, the left ventricle had its wall preserved in all cases. CONCLUSION: This experimental model can certainly reproduce nearly the reality, confirming good parameters of prothetics stentless evaluation in the aortic position. And the sheep declared itself to be pleasant, which helps us its control during the whole study.INTRODUÇÃO: O tratamento das lesões valvares representa um grande desafio dentro da cirurgia cardiovascular, pois, até os dias atuais, não temos um substituto ideal para as valvas do coração. As próteses atualmente disponíveis apresentam vantagens e desvantagens; as mecânicas exigem anticoagulação definitiva e as biológicas apresentam baixa durabilidade. Para se chegar a um substituto ideal, são necessárias várias fases, desde a escolha e o preparo do material até o implante em animal de grande porte. Esta última é muito importante, pois a escolha do animal deve ser criteriosa. Ovinos juvenís são animais dóceis de fácil manipulação e suas características anatômicas e biológicas se assemelham muito ao que ocorre com o ser humano e as próteses stentless são substitutos mais próximos dos homoenxertos. MATERIAL E MÉTODO: Foram operados 30 ovinos juvenís com idade variando de 4,4 a 6,3 meses, peso de 25 a 37 kg, sendo 28 machos. Todos os animais foram submetidos a circulação extracorpórea para implante de bioprótese stentless montada em tubo de aorta porcina, com reimplante de artérias coronárias. A operação foi realizada com hipotermia moderada e cardioplegia gelada. O período de seguimento foi de 30 dias e, ao final, realizado ecocardiograma. RESULTADOS: Houve 8 (26,6%) óbitos no intra-operatório e 6 (27,7%) óbitos no seguimento. O tempo médio de CEC foi de 98 min. Foi realizado ecocardiograma em 16 animais e em nenhum caso foram vistos sinais de endocardite ou outras alterações; a fração média de ejeção foi de 74%. CONCLUSÃO: Este modelo experimental utilizando ovinos para o estudo de biopróteses stentless em posição aórtica mostrou-se bem reprodutível e a performance do enxerto bastante factível de ser avaliada, pois ovinos são animais dóceis e de fácil manipulação no seguimento tardio.Universidade de Federal de São Paulo Escola Paulista de Medicina Disciplina de Cirurgia CardiovascularLabcor Centro de PesquisaUniversidade de Federal de São Paulo Escola Paulista de Medicina Disciplina de Cirurgia CardiovascularSciELOSociedade Brasileira de Cirurgia CardiovascularUniversidade Federal de São Paulo (UNIFESP)Labcor Centro de PesquisaSantos, Paulo César [UNIFESP]Gerola, Luís Roberto [UNIFESP]Pessa, Clodualdo J.N. [UNIFESP]Branco, João Nelson Rodrigues [UNIFESP]Casagrande, Ivan Sergio JovianoBuffolo, Enio [UNIFESP]2015-06-14T13:29:38Z2015-06-14T13:29:38Z2002-03-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion90-98application/pdfhttp://dx.doi.org/10.1590/S0102-76382002000100013Revista Brasileira de Cirurgia Cardiovascular. Sociedade Brasileira de Cirurgia Cardiovascular, v. 17, n. 1, p. 90-98, 2002.10.1590/S0102-76382002000100013S0102-76382002000100013.pdf0102-7638S0102-76382002000100013http://repositorio.unifesp.br/handle/11600/1379porRevista Brasileira de Cirurgia Cardiovascularinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T20:00:53Zoai:repositorio.unifesp.br/:11600/1379Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-07-29T20:00:53Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
A juvenile sheep model for the stentless bioprostheses implanted as aortic root replacements
title Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
spellingShingle Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
Santos, Paulo César [UNIFESP]
Aortic valve
Blood vessel prosthesis, implantation
Bioprosthesis
Valva aórtica
Implante de prótese vascular
Biopróteses
title_short Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
title_full Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
title_fullStr Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
title_full_unstemmed Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
title_sort Implante de tubo valvulado bioprótese stentless em posição aórtica: estudo experimental em ovinos
author Santos, Paulo César [UNIFESP]
author_facet Santos, Paulo César [UNIFESP]
Gerola, Luís Roberto [UNIFESP]
Pessa, Clodualdo J.N. [UNIFESP]
Branco, João Nelson Rodrigues [UNIFESP]
Casagrande, Ivan Sergio Joviano
Buffolo, Enio [UNIFESP]
author_role author
author2 Gerola, Luís Roberto [UNIFESP]
Pessa, Clodualdo J.N. [UNIFESP]
Branco, João Nelson Rodrigues [UNIFESP]
Casagrande, Ivan Sergio Joviano
Buffolo, Enio [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
Labcor Centro de Pesquisa
dc.contributor.author.fl_str_mv Santos, Paulo César [UNIFESP]
Gerola, Luís Roberto [UNIFESP]
Pessa, Clodualdo J.N. [UNIFESP]
Branco, João Nelson Rodrigues [UNIFESP]
Casagrande, Ivan Sergio Joviano
Buffolo, Enio [UNIFESP]
dc.subject.por.fl_str_mv Aortic valve
Blood vessel prosthesis, implantation
Bioprosthesis
Valva aórtica
Implante de prótese vascular
Biopróteses
topic Aortic valve
Blood vessel prosthesis, implantation
Bioprosthesis
Valva aórtica
Implante de prótese vascular
Biopróteses
description INTRODUCTION: Often, studies on aortic prosthetic valves analyze their performance not at the primitive position, but using tricuspid and mitral ones or inserting it in the descending aortic area. Taking that into account, it would be relevant to observe results in those studies in which the conclusions are based on their original implantation. MATERIAL AND METHODS: Thirty young sheep, 28 males and 2 females, were operated on. Ages ranged 4.4 to 6.3 months and weights 25 to 37 Kg. Extra corporeal circulation (ECC) was applied to all the animals, always guided by the conventional criteria, that is to say, the arterial cannula was inserted in the thoracic aorta just past the arterious ducts and the venous cannulae, a single one, was placed in the right atrium. The operation was performed according to the principle of moderately low body temperature- 29ºC- and cold cristalloid cardioplegia, in the aortic root, to induce; but otherwise was utilized blood to the maintenance. Following with the technique proposed, the aortic valve of the animal heart was completely excised and finally implanted the valved tube stentless, not forgetting the refixation of the coronary main. The sheep were kept in clinical and laboratorial observation during thirty days in what was included a echocardiogram in the end. RESULTS: The results demonstrated 8 intraoperatory deaths (26.6%), and 6 during the following (27.7%). The mean time of ECC was 98 minutes. The dimension of the majority prothetics valves were 21 and 23. Only two valves evoluted with mild insufficiency, none denoted evidences of the endocarditis neither of leaflets perfuration, the mean fraction of ejection was 74%, the left ventricle had its wall preserved in all cases. CONCLUSION: This experimental model can certainly reproduce nearly the reality, confirming good parameters of prothetics stentless evaluation in the aortic position. And the sheep declared itself to be pleasant, which helps us its control during the whole study.
publishDate 2002
dc.date.none.fl_str_mv 2002-03-01
2015-06-14T13:29:38Z
2015-06-14T13:29:38Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0102-76382002000100013
Revista Brasileira de Cirurgia Cardiovascular. Sociedade Brasileira de Cirurgia Cardiovascular, v. 17, n. 1, p. 90-98, 2002.
10.1590/S0102-76382002000100013
S0102-76382002000100013.pdf
0102-7638
S0102-76382002000100013
http://repositorio.unifesp.br/handle/11600/1379
url http://dx.doi.org/10.1590/S0102-76382002000100013
http://repositorio.unifesp.br/handle/11600/1379
identifier_str_mv Revista Brasileira de Cirurgia Cardiovascular. Sociedade Brasileira de Cirurgia Cardiovascular, v. 17, n. 1, p. 90-98, 2002.
10.1590/S0102-76382002000100013
S0102-76382002000100013.pdf
0102-7638
S0102-76382002000100013
dc.language.iso.fl_str_mv por
language por
dc.relation.none.fl_str_mv Revista Brasileira de Cirurgia Cardiovascular
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 90-98
application/pdf
dc.publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
publisher.none.fl_str_mv Sociedade Brasileira de Cirurgia Cardiovascular
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268356807622656