Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia

Detalhes bibliográficos
Autor(a) principal: Lopes, Larissa Barbosa [UNIFESP]
Data de Publicação: 2018
Outros Autores: Abbas, Samira Ali [UNIFESP], Moritz, Elyse [UNIFESP], Martins, Juliana Oliveira [UNIFESP], Chiba, Akemi Kuroda [UNIFESP], Langhi Júnior, Dante Mário [UNIFESP], Bordin, Jose Orlando [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/55582
http://dx.doi.org/10.1111/trf.14524
Resumo: BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a
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repository_id_str 3465
spelling Lopes, Larissa Barbosa [UNIFESP]Abbas, Samira Ali [UNIFESP]Moritz, Elyse [UNIFESP]Martins, Juliana Oliveira [UNIFESP]Chiba, Akemi Kuroda [UNIFESP]Langhi Júnior, Dante Mário [UNIFESP]Bordin, Jose Orlando [UNIFESP]2020-07-20T16:30:54Z2020-07-20T16:30:54Z2018Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018.0041-1132https://repositorio.unifesp.br/handle/11600/55582http://dx.doi.org/10.1111/trf.1452410.1111/trf.14524WOS:000430691300025BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5ahowever, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODSBlood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1.5 x 10(9)/L) from 83 mothers (three pairs of twins and one triplet). HNA-3 genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism to identify the cases of maternal-fetal HNA-3 incompatibility. Serologic studies for detecting maternal HNA-3 alloantibodies were performed with the granulocyte agglutination test, the white blood cell immunofluorescence test, and a LABScreen Multi-HNA Kit. RESULTSGenotyping studies identified 13 of 88 (14.8%) instances of maternal-fetal HNA-3 incompatibility, with all mothers typed as HNA-3a/a and neonates typed as HNA-3a/b. Serologic studies revealed that five of 13 (38.5%) mothers carried anti-HNA-3b plus human leukocyte antigen antibodies and that three of 13 (23.1%) mothers had anti-HNA-3b without human leukocyte antigen antibodies. CONCLUSIONHere, we report the first three cases of neonatal alloimmune neutropenia associated with HNA-3b antibodies resulting in a neonatal alloimmune neutropenia incidence of one in 3333 live births.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) "Doctoral Fellowship"Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) "Edital Universal"Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)-"Programa Institucional de Doutorado Sanduiche no Exterior"/PDSECoordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)-"Postdoctoral Fellowship"/PNPDUniv Fed Sao Paulo, UNIFESP, Disciplina Hematol & Hemoterapia, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Disciplina Hematol & Hemoterapia, Sao Paulo, BrazilCNPq: 142825/2009-3CNPq: 475806/2010-7CAPES: 7352/12-3Web of Science1264-1270engWileyTransfusionAntibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropeniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHobokenv. 585info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/555822021-10-04 21:26:15.334metadata only accessoai:repositorio.unifesp.br:11600/55582Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-05T00:26:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
title Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
spellingShingle Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
Lopes, Larissa Barbosa [UNIFESP]
title_short Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
title_full Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
title_fullStr Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
title_full_unstemmed Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
title_sort Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
author Lopes, Larissa Barbosa [UNIFESP]
author_facet Lopes, Larissa Barbosa [UNIFESP]
Abbas, Samira Ali [UNIFESP]
Moritz, Elyse [UNIFESP]
Martins, Juliana Oliveira [UNIFESP]
Chiba, Akemi Kuroda [UNIFESP]
Langhi Júnior, Dante Mário [UNIFESP]
Bordin, Jose Orlando [UNIFESP]
author_role author
author2 Abbas, Samira Ali [UNIFESP]
Moritz, Elyse [UNIFESP]
Martins, Juliana Oliveira [UNIFESP]
Chiba, Akemi Kuroda [UNIFESP]
Langhi Júnior, Dante Mário [UNIFESP]
Bordin, Jose Orlando [UNIFESP]
author2_role author
author
author
author
author
author
dc.contributor.author.fl_str_mv Lopes, Larissa Barbosa [UNIFESP]
Abbas, Samira Ali [UNIFESP]
Moritz, Elyse [UNIFESP]
Martins, Juliana Oliveira [UNIFESP]
Chiba, Akemi Kuroda [UNIFESP]
Langhi Júnior, Dante Mário [UNIFESP]
Bordin, Jose Orlando [UNIFESP]
description BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a
publishDate 2018
dc.date.issued.fl_str_mv 2018
dc.date.accessioned.fl_str_mv 2020-07-20T16:30:54Z
dc.date.available.fl_str_mv 2020-07-20T16:30:54Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
format article
status_str publishedVersion
dc.identifier.citation.fl_str_mv Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/55582
http://dx.doi.org/10.1111/trf.14524
dc.identifier.issn.none.fl_str_mv 0041-1132
dc.identifier.doi.none.fl_str_mv 10.1111/trf.14524
dc.identifier.wos.none.fl_str_mv WOS:000430691300025
identifier_str_mv Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018.
0041-1132
10.1111/trf.14524
WOS:000430691300025
url https://repositorio.unifesp.br/handle/11600/55582
http://dx.doi.org/10.1111/trf.14524
dc.language.iso.fl_str_mv eng
language eng
dc.relation.ispartof.none.fl_str_mv Transfusion
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 1264-1270
dc.coverage.none.fl_str_mv Hoboken
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv
_version_ 1802764128106840064

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