Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/55582 http://dx.doi.org/10.1111/trf.14524 |
Resumo: | BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a |
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Repositório Institucional da UNIFESP |
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3465 |
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Lopes, Larissa Barbosa [UNIFESP]Abbas, Samira Ali [UNIFESP]Moritz, Elyse [UNIFESP]Martins, Juliana Oliveira [UNIFESP]Chiba, Akemi Kuroda [UNIFESP]Langhi Júnior, Dante Mário [UNIFESP]Bordin, Jose Orlando [UNIFESP]2020-07-20T16:30:54Z2020-07-20T16:30:54Z2018Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018.0041-1132https://repositorio.unifesp.br/handle/11600/55582http://dx.doi.org/10.1111/trf.1452410.1111/trf.14524WOS:000430691300025BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5ahowever, to date, antibodies specific to HNA-3b have not been reported. STUDY DESIGN AND METHODSBlood samples from 10,000 unselected neonates were analyzed, resulting in the selection of 88 neutropenic newborns (neutrophil count <1.5 x 10(9)/L) from 83 mothers (three pairs of twins and one triplet). HNA-3 genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism to identify the cases of maternal-fetal HNA-3 incompatibility. Serologic studies for detecting maternal HNA-3 alloantibodies were performed with the granulocyte agglutination test, the white blood cell immunofluorescence test, and a LABScreen Multi-HNA Kit. RESULTSGenotyping studies identified 13 of 88 (14.8%) instances of maternal-fetal HNA-3 incompatibility, with all mothers typed as HNA-3a/a and neonates typed as HNA-3a/b. Serologic studies revealed that five of 13 (38.5%) mothers carried anti-HNA-3b plus human leukocyte antigen antibodies and that three of 13 (23.1%) mothers had anti-HNA-3b without human leukocyte antigen antibodies. CONCLUSIONHere, we report the first three cases of neonatal alloimmune neutropenia associated with HNA-3b antibodies resulting in a neonatal alloimmune neutropenia incidence of one in 3333 live births.Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) "Doctoral Fellowship"Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) "Edital Universal"Coordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)-"Programa Institucional de Doutorado Sanduiche no Exterior"/PDSECoordenacao de Aperfeicoamento Pessoal de Nivel Superior (CAPES)-"Postdoctoral Fellowship"/PNPDUniv Fed Sao Paulo, UNIFESP, Disciplina Hematol & Hemoterapia, Sao Paulo, BrazilUniv Fed Sao Paulo, UNIFESP, Disciplina Hematol & Hemoterapia, Sao Paulo, BrazilCNPq: 142825/2009-3CNPq: 475806/2010-7CAPES: 7352/12-3Web of Science1264-1270engWileyTransfusionAntibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropeniainfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleHobokenv. 585info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP11600/555822021-10-04 21:26:15.334metadata only accessoai:repositorio.unifesp.br:11600/55582Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652021-10-05T00:26:15Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
title |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
spellingShingle |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia Lopes, Larissa Barbosa [UNIFESP] |
title_short |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
title_full |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
title_fullStr |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
title_full_unstemmed |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
title_sort |
Antibodies to human neutrophil antigen HNA-3b implicated in cases of neonatal alloimmune neutropenia |
author |
Lopes, Larissa Barbosa [UNIFESP] |
author_facet |
Lopes, Larissa Barbosa [UNIFESP] Abbas, Samira Ali [UNIFESP] Moritz, Elyse [UNIFESP] Martins, Juliana Oliveira [UNIFESP] Chiba, Akemi Kuroda [UNIFESP] Langhi Júnior, Dante Mário [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
author_role |
author |
author2 |
Abbas, Samira Ali [UNIFESP] Moritz, Elyse [UNIFESP] Martins, Juliana Oliveira [UNIFESP] Chiba, Akemi Kuroda [UNIFESP] Langhi Júnior, Dante Mário [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.author.fl_str_mv |
Lopes, Larissa Barbosa [UNIFESP] Abbas, Samira Ali [UNIFESP] Moritz, Elyse [UNIFESP] Martins, Juliana Oliveira [UNIFESP] Chiba, Akemi Kuroda [UNIFESP] Langhi Júnior, Dante Mário [UNIFESP] Bordin, Jose Orlando [UNIFESP] |
description |
BACKGROUNDNeonatal alloimmune neutropenia results from maternal alloimmunization to human neutrophil antigens. The alloantibodies involved in neonatal alloimmune neutropenia are against human neutrophil antigens HNA-1a, HNA-1b, HNA-1c, HNA-1d, HNA-2, HNA-3a, HNA-4a, HNA-4b, and HNA-5a |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-20T16:30:54Z |
dc.date.available.fl_str_mv |
2020-07-20T16:30:54Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/55582 http://dx.doi.org/10.1111/trf.14524 |
dc.identifier.issn.none.fl_str_mv |
0041-1132 |
dc.identifier.doi.none.fl_str_mv |
10.1111/trf.14524 |
dc.identifier.wos.none.fl_str_mv |
WOS:000430691300025 |
identifier_str_mv |
Transfusion. Hoboken, v. 58, n. 5, p. 1264-1270, 2018. 0041-1132 10.1111/trf.14524 WOS:000430691300025 |
url |
https://repositorio.unifesp.br/handle/11600/55582 http://dx.doi.org/10.1111/trf.14524 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Transfusion |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
1264-1270 |
dc.coverage.none.fl_str_mv |
Hoboken |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1802764128106840064 |