PCSK9 and its clinical importance with the new therapeutic targets against dyslipidemia

• Autor(a) principal: Ferreira, Carlos Eduardo dos Santos [UNIFESP]
• Data de Publicação: 2012
• Outros Autores: Fonseca, Francisco Antonio Helfenstein [UNIFESP], Mangueira, Cristóvão Luis Pitangueiras
• Tipo de documento: Artigo
• Idioma: eng
• Título da fonte: Repositório Institucional da UNIFESP
• Texto Completo: http://repositorio.unifesp.br/handle/11600/7425
• topic: Dyslipidemias; Lipoproteins; Cholesterol, LDL; Dislipidemias; Lipoproteínas; LDL-colesterol

This is a remarkable progress; since the finding of statins, there was no new way of reducing, significantly, cholesterol and LDL fraction. It is also clear that this decrease, by statins, is related to future cardiovascular lesions, being useful in its primary and secondary prophylaxis. The authors presented studies on research to promote the falling of blood cholesterol by means of antibodies, which inhibit the pro-protein PCSK9, as well as agents that act performing the RNA interference. We had two advantages immediately: for patients with myopathy associated with statins, and the fact of being injected every 15 days, that may contribute to better treatment adherence.