Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats
Autor(a) principal: | |
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Data de Publicação: | 2018 |
Outros Autores: | , , , , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | https://repositorio.unifesp.br/handle/11600/54261 https://dx.doi.org/10.3389/fphys.2017.01042 |
Resumo: | Cardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have focused on the effects of leucine supplementation as a strategy to minimize or revert the clinical condition of induced proteolysis by several clinical onsets. However, the impact of leucine supplementation in heart failure induced by doxorubicin is unknown. Therefore, the objective of this work is to evaluate the effects of leucine supplementation on the cardiotoxicity in the heart of rats treated with doxorubicin. Rats treated with a 7.5 mg/kg cumulative dose of doxorubicin for 14 days presented a dilatation of the left ventricle (LV), and a reduction of the ejection fraction (FE). The 5% supplementation of leucine in the rats' food prevented the malfunctioning of the LV when administered with doxorubicin. Some alterations in the extracellular matrix remodeling were confirmed by the increase of collagen fibers in the doxorubicin group, which did not increase when the treatment was associated with leucine supplementation. Leucine attenuates heart failure in this experimental model with doxorubicin. Such protection is followed by the maintenance of interstitial collagen fibers. |
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Fidale, Thiago MontesAntunes, Hanna Karen Moreira [UNIFESP]Santos, Luciano Alex dosSouza, Fernanda Rodrigues deDeconte, Simone RamosMoura, Francyelle Borges Rosa deMantovani, Matheus MatioliAlves, Poliana RodriguesRoever, LeonardoResende, Elmiro SantosUniversidade Federal de São Paulo (UNIFESP)2020-07-08T13:09:52Z2020-07-08T13:09:52Z2018Frontiers In Physiology. Lausanne, v. 8, p. -, 2018.1664-042Xhttps://repositorio.unifesp.br/handle/11600/54261https://dx.doi.org/10.3389/fphys.2017.01042WOS000422692600001.pdf10.3389/fphys.2017.01042WOS:000422692600001Cardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have focused on the effects of leucine supplementation as a strategy to minimize or revert the clinical condition of induced proteolysis by several clinical onsets. However, the impact of leucine supplementation in heart failure induced by doxorubicin is unknown. Therefore, the objective of this work is to evaluate the effects of leucine supplementation on the cardiotoxicity in the heart of rats treated with doxorubicin. Rats treated with a 7.5 mg/kg cumulative dose of doxorubicin for 14 days presented a dilatation of the left ventricle (LV), and a reduction of the ejection fraction (FE). The 5% supplementation of leucine in the rats' food prevented the malfunctioning of the LV when administered with doxorubicin. Some alterations in the extracellular matrix remodeling were confirmed by the increase of collagen fibers in the doxorubicin group, which did not increase when the treatment was associated with leucine supplementation. Leucine attenuates heart failure in this experimental model with doxorubicin. Such protection is followed by the maintenance of interstitial collagen fibers.Univ Fed Uberlandia, Lab Expt Med, Uberlandia, MG, BrazilUniv Fed Sao Paulo, Dept Biosci, Sao Paulo, BrazilUniv Fed Uberlandia, Inst Biomed Sci, Uberlandia, MG, BrazilUniv Fed Uberlandia, Veterinarian Hosp, Uberlandia, MG, BrazilUniv Fed Sao Paulo, Dept Biosci, Sao Paulo, BrazilWeb of Science-engFrontiers Media SaFrontiers In PhysiologyDoxorubicinCardiotoxicityLeucineBCAAHeart failureIncreased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Ratsinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLausanne8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000422692600001.pdfapplication/pdf1704195${dspace.ui.url}/bitstream/11600/54261/1/WOS000422692600001.pdf849526b823b58bb0b9632c3eaca9dc5aMD51open accessTEXTWOS000422692600001.pdf.txtWOS000422692600001.pdf.txtExtracted texttext/plain29681${dspace.ui.url}/bitstream/11600/54261/5/WOS000422692600001.pdf.txt8244cb749f3c37506549e1ebddb287d0MD55open accessTHUMBNAILWOS000422692600001.pdf.jpgWOS000422692600001.pdf.jpgIM Thumbnailimage/jpeg7094${dspace.ui.url}/bitstream/11600/54261/7/WOS000422692600001.pdf.jpge60fa0dfc9d4d79cc430a4676af17b05MD57open access11600/542612023-06-05 19:17:30.629open accessoai:repositorio.unifesp.br:11600/54261Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:17:30Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
title |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
spellingShingle |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats Fidale, Thiago Montes Doxorubicin Cardiotoxicity Leucine BCAA Heart failure |
title_short |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
title_full |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
title_fullStr |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
title_full_unstemmed |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
title_sort |
Increased Dietary Leucine Reduces Doxorubicin-Associated Cardiac Dysfunction in Rats |
author |
Fidale, Thiago Montes |
author_facet |
Fidale, Thiago Montes Antunes, Hanna Karen Moreira [UNIFESP] Santos, Luciano Alex dos Souza, Fernanda Rodrigues de Deconte, Simone Ramos Moura, Francyelle Borges Rosa de Mantovani, Matheus Matioli Alves, Poliana Rodrigues Roever, Leonardo Resende, Elmiro Santos |
author_role |
author |
author2 |
Antunes, Hanna Karen Moreira [UNIFESP] Santos, Luciano Alex dos Souza, Fernanda Rodrigues de Deconte, Simone Ramos Moura, Francyelle Borges Rosa de Mantovani, Matheus Matioli Alves, Poliana Rodrigues Roever, Leonardo Resende, Elmiro Santos |
author2_role |
author author author author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Fidale, Thiago Montes Antunes, Hanna Karen Moreira [UNIFESP] Santos, Luciano Alex dos Souza, Fernanda Rodrigues de Deconte, Simone Ramos Moura, Francyelle Borges Rosa de Mantovani, Matheus Matioli Alves, Poliana Rodrigues Roever, Leonardo Resende, Elmiro Santos |
dc.subject.eng.fl_str_mv |
Doxorubicin Cardiotoxicity Leucine BCAA Heart failure |
topic |
Doxorubicin Cardiotoxicity Leucine BCAA Heart failure |
description |
Cardiotoxicity is one of the most significant adverse effects of the oncologic treatment with doxorubicin, which is responsible for a substantial morbid and mortality. The occurrence of heart failure with ventricular dysfunction may lead to severe cardiomyopathy and ultimately to death. Studies have focused on the effects of leucine supplementation as a strategy to minimize or revert the clinical condition of induced proteolysis by several clinical onsets. However, the impact of leucine supplementation in heart failure induced by doxorubicin is unknown. Therefore, the objective of this work is to evaluate the effects of leucine supplementation on the cardiotoxicity in the heart of rats treated with doxorubicin. Rats treated with a 7.5 mg/kg cumulative dose of doxorubicin for 14 days presented a dilatation of the left ventricle (LV), and a reduction of the ejection fraction (FE). The 5% supplementation of leucine in the rats' food prevented the malfunctioning of the LV when administered with doxorubicin. Some alterations in the extracellular matrix remodeling were confirmed by the increase of collagen fibers in the doxorubicin group, which did not increase when the treatment was associated with leucine supplementation. Leucine attenuates heart failure in this experimental model with doxorubicin. Such protection is followed by the maintenance of interstitial collagen fibers. |
publishDate |
2018 |
dc.date.issued.fl_str_mv |
2018 |
dc.date.accessioned.fl_str_mv |
2020-07-08T13:09:52Z |
dc.date.available.fl_str_mv |
2020-07-08T13:09:52Z |
dc.type.status.fl_str_mv |
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article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Frontiers In Physiology. Lausanne, v. 8, p. -, 2018. |
dc.identifier.uri.fl_str_mv |
https://repositorio.unifesp.br/handle/11600/54261 https://dx.doi.org/10.3389/fphys.2017.01042 |
dc.identifier.issn.none.fl_str_mv |
1664-042X |
dc.identifier.file.none.fl_str_mv |
WOS000422692600001.pdf |
dc.identifier.doi.none.fl_str_mv |
10.3389/fphys.2017.01042 |
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WOS:000422692600001 |
identifier_str_mv |
Frontiers In Physiology. Lausanne, v. 8, p. -, 2018. 1664-042X WOS000422692600001.pdf 10.3389/fphys.2017.01042 WOS:000422692600001 |
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https://repositorio.unifesp.br/handle/11600/54261 https://dx.doi.org/10.3389/fphys.2017.01042 |
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Frontiers Media Sa |
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