Intrastromal injection of bevacizumab in patients with corneal neovascularization

Detalhes bibliográficos
Autor(a) principal: Vieira, Ana Carolina Cabreira [UNIFESP]
Data de Publicação: 2012
Outros Autores: Hofling-Lima, Ana Luisa [UNIFESP], Gomes, José Álvaro Pereira [UNIFESP], Freitas, Denise de [UNIFESP], Farah, Michel Eid [UNIFESP], Belfort, Rubens Junior [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
dARK ID: ark:/48912/001300001b4gh
DOI: 10.1590/S0004-27492012000400012
Texto Completo: http://dx.doi.org/10.1590/S0004-27492012000400012
http://repositorio.unifesp.br/handle/11600/7252
Resumo: Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. Anti-VEGF agents have been shown to be effective in slowing the growth of corneal neovessels. Bevacizumab, an anti-VEGF agent, has been successfully used in the treatment of corneal neovascularization. In this paper, we report a series of patients who underwent intracorneal bevacizumab injections to treat corneal vascularization.
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spelling Intrastromal injection of bevacizumab in patients with corneal neovascularizationInjeção intraestromal de bevacizumabe em pacientes com neovascularização corneanaCorneal stromaCorneal neovascularizationInjections, intraocularAntibodies, monoclonalSubstância própriaNeovascularização da córneaInjeções intraocularesAnticorpos monoclonaisCorneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. Anti-VEGF agents have been shown to be effective in slowing the growth of corneal neovessels. Bevacizumab, an anti-VEGF agent, has been successfully used in the treatment of corneal neovascularization. In this paper, we report a series of patients who underwent intracorneal bevacizumab injections to treat corneal vascularization.Além de causar redução da acuidade visual, a neovascularização corneana leva à perda do privilégio imunológico da córnea, contribuindo para um pior prognóstico em casos de ceratoplastia penetrante. Diversos mediadores participam da angiogênese corneana. O papel do fator de crescimento endothelial vascular (VEGF) já foi amplamente descrito. Agentes inibidores do VEGF são eficazes na redução do crescimento de neovasos corneanos. Bevacizumabe, um agente anti-VEGF, tem sido utilizado com sucesso no tratamento de neovascularização corneana. Neste artigo, relatamos uma série de pacientes que foram submetidos à injeção intraestromal de bevacizumabe para o tratamento de vascularização corneana.Universidade Federal de São Paulo (UNIFESP) Vision Institute Department of OphthalmologyUNIFESP, Vision Institute Department of OphthalmologySciELOConselho Brasileiro de OftalmologiaUniversidade Federal de São Paulo (UNIFESP)Vieira, Ana Carolina Cabreira [UNIFESP]Hofling-Lima, Ana Luisa [UNIFESP]Gomes, José Álvaro Pereira [UNIFESP]Freitas, Denise de [UNIFESP]Farah, Michel Eid [UNIFESP]Belfort, Rubens Junior [UNIFESP]2015-06-14T13:44:53Z2015-06-14T13:44:53Z2012-08-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion277-279application/pdfhttp://dx.doi.org/10.1590/S0004-27492012000400012Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 75, n. 4, p. 277-279, 2012.10.1590/S0004-27492012000400012S0004-27492012000400012.pdf0004-2749S0004-27492012000400012http://repositorio.unifesp.br/handle/11600/7252WOS:000312669300012ark:/48912/001300001b4ghengArquivos Brasileiros de Oftalmologiainfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-07-29T11:01:35Zoai:repositorio.unifesp.br/:11600/7252Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-12-11T21:06:59.820966Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Intrastromal injection of bevacizumab in patients with corneal neovascularization
Injeção intraestromal de bevacizumabe em pacientes com neovascularização corneana
title Intrastromal injection of bevacizumab in patients with corneal neovascularization
spellingShingle Intrastromal injection of bevacizumab in patients with corneal neovascularization
Intrastromal injection of bevacizumab in patients with corneal neovascularization
Vieira, Ana Carolina Cabreira [UNIFESP]
Corneal stroma
Corneal neovascularization
Injections, intraocular
Antibodies, monoclonal
Substância própria
Neovascularização da córnea
Injeções intraoculares
Anticorpos monoclonais
Vieira, Ana Carolina Cabreira [UNIFESP]
Corneal stroma
Corneal neovascularization
Injections, intraocular
Antibodies, monoclonal
Substância própria
Neovascularização da córnea
Injeções intraoculares
Anticorpos monoclonais
title_short Intrastromal injection of bevacizumab in patients with corneal neovascularization
title_full Intrastromal injection of bevacizumab in patients with corneal neovascularization
title_fullStr Intrastromal injection of bevacizumab in patients with corneal neovascularization
Intrastromal injection of bevacizumab in patients with corneal neovascularization
title_full_unstemmed Intrastromal injection of bevacizumab in patients with corneal neovascularization
Intrastromal injection of bevacizumab in patients with corneal neovascularization
title_sort Intrastromal injection of bevacizumab in patients with corneal neovascularization
author Vieira, Ana Carolina Cabreira [UNIFESP]
author_facet Vieira, Ana Carolina Cabreira [UNIFESP]
Vieira, Ana Carolina Cabreira [UNIFESP]
Hofling-Lima, Ana Luisa [UNIFESP]
Gomes, José Álvaro Pereira [UNIFESP]
Freitas, Denise de [UNIFESP]
Farah, Michel Eid [UNIFESP]
Belfort, Rubens Junior [UNIFESP]
Hofling-Lima, Ana Luisa [UNIFESP]
Gomes, José Álvaro Pereira [UNIFESP]
Freitas, Denise de [UNIFESP]
Farah, Michel Eid [UNIFESP]
Belfort, Rubens Junior [UNIFESP]
author_role author
author2 Hofling-Lima, Ana Luisa [UNIFESP]
Gomes, José Álvaro Pereira [UNIFESP]
Freitas, Denise de [UNIFESP]
Farah, Michel Eid [UNIFESP]
Belfort, Rubens Junior [UNIFESP]
author2_role author
author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
dc.contributor.author.fl_str_mv Vieira, Ana Carolina Cabreira [UNIFESP]
Hofling-Lima, Ana Luisa [UNIFESP]
Gomes, José Álvaro Pereira [UNIFESP]
Freitas, Denise de [UNIFESP]
Farah, Michel Eid [UNIFESP]
Belfort, Rubens Junior [UNIFESP]
dc.subject.por.fl_str_mv Corneal stroma
Corneal neovascularization
Injections, intraocular
Antibodies, monoclonal
Substância própria
Neovascularização da córnea
Injeções intraoculares
Anticorpos monoclonais
topic Corneal stroma
Corneal neovascularization
Injections, intraocular
Antibodies, monoclonal
Substância própria
Neovascularização da córnea
Injeções intraoculares
Anticorpos monoclonais
description Corneal neovascularization (NV) not only reduces visual acuity, but it also causes loss of the cornea's immune privilege, strongly contributing to a worse prognosis in penetrating keratoplasty. Several mediators participate in corneal angiogenesis, and the role of vascular endothelial growth factor (VEGF) has been extensively proven. Anti-VEGF agents have been shown to be effective in slowing the growth of corneal neovessels. Bevacizumab, an anti-VEGF agent, has been successfully used in the treatment of corneal neovascularization. In this paper, we report a series of patients who underwent intracorneal bevacizumab injections to treat corneal vascularization.
publishDate 2012
dc.date.none.fl_str_mv 2012-08-01
2015-06-14T13:44:53Z
2015-06-14T13:44:53Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1590/S0004-27492012000400012
Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 75, n. 4, p. 277-279, 2012.
10.1590/S0004-27492012000400012
S0004-27492012000400012.pdf
0004-2749
S0004-27492012000400012
http://repositorio.unifesp.br/handle/11600/7252
WOS:000312669300012
dc.identifier.dark.fl_str_mv ark:/48912/001300001b4gh
url http://dx.doi.org/10.1590/S0004-27492012000400012
http://repositorio.unifesp.br/handle/11600/7252
identifier_str_mv Arquivos Brasileiros de Oftalmologia. Conselho Brasileiro de Oftalmologia, v. 75, n. 4, p. 277-279, 2012.
10.1590/S0004-27492012000400012
S0004-27492012000400012.pdf
0004-2749
S0004-27492012000400012
WOS:000312669300012
ark:/48912/001300001b4gh
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Arquivos Brasileiros de Oftalmologia
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 277-279
application/pdf
dc.publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
publisher.none.fl_str_mv Conselho Brasileiro de Oftalmologia
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1822219244765446145
dc.identifier.doi.none.fl_str_mv 10.1590/S0004-27492012000400012

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