Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis

Detalhes bibliográficos
Autor(a) principal: Lopes, Celso [UNIFESP]
Data de Publicação: 2016
Outros Autores: Trevisani, Virginia Fernandes Moca [UNIFESP], Melnik, Tamara [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://doi.org/10.1007/s40257-015-0164-2
https://repositorio.unifesp.br/handle/11600/58635
Resumo: Background Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment.
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spelling Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-AnalysisBackground Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment.Fed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, BrazilSanto Amaro Univ UNISA, Discipline Rheumatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, BrazilBrazilian Cochrane Ctr, Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, BrazilFed Univ Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Div Emergency Med & Evidence Based Med, Sao Paulo, BrazilFed Univ Sao Paulo UNIFESP, Internal Med & Evidence Based Med, Sao Paulo, BrazilUniv Fed Sao Paulo, Disciplina Med Baseada Evidencia, Rua Botucatu,740-3 Andar Vila Clementino, BR-04023900 Sao Paulo, SP, BrazilWeb of ScienceAdis Int Ltd2020-11-03T14:40:36Z2020-11-03T14:40:36Z2016info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion23-32https://doi.org/10.1007/s40257-015-0164-2American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016.10.1007/s40257-015-0164-21175-0561https://repositorio.unifesp.br/handle/11600/58635WOS:000368988100003engAmerican Journal Of Clinical DermatologyNorthcoteinfo:eu-repo/semantics/openAccessLopes, Celso [UNIFESP]Trevisani, Virginia Fernandes Moca [UNIFESP]Melnik, Tamara [UNIFESP]reponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2021-09-30T14:22:54Zoai:repositorio.unifesp.br/:11600/58635Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652021-09-30T14:22:54Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
title Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
spellingShingle Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
Lopes, Celso [UNIFESP]
title_short Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
title_full Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
title_fullStr Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
title_full_unstemmed Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
title_sort Efficacy and Safety of 308-nm Monochromatic Excimer Lamp Versus Other Phototherapy Devices for Vitiligo: A Systematic Review with Meta-Analysis
author Lopes, Celso [UNIFESP]
author_facet Lopes, Celso [UNIFESP]
Trevisani, Virginia Fernandes Moca [UNIFESP]
Melnik, Tamara [UNIFESP]
author_role author
author2 Trevisani, Virginia Fernandes Moca [UNIFESP]
Melnik, Tamara [UNIFESP]
author2_role author
author
dc.contributor.author.fl_str_mv Lopes, Celso [UNIFESP]
Trevisani, Virginia Fernandes Moca [UNIFESP]
Melnik, Tamara [UNIFESP]
description Background Various phototherapy methods are used to treat vitiligo; however, the recent emergence of new devices has heightened debate concerning the best treatment method. Objective We aimed to systematically review and meta-analyze published data comparing the efficacy and adverse effects of monochromatic excimer lamps versus excimer laser and narrowband ultraviolet B (NB-UVB) in treating vitiligo. Methods A systematic search of PubMed, EMBASE, LILACS, Cochrane Central Register of Controlled Trials (CENTRAL), and clinical trials registries identified randomized controlled trials that included vitiligo patients, regardless of age, sex, or study language. We evaluated studies comparing excimer lamps with excimer laser or NB-UVB phototherapy. Results The review included six studies (411 patients, 764 lesions). No study found significantly different efficacy between excimer lamps and excimer laser using the outcomes of >= 50 % repigmentation [risk ratio (RR) = 0.97, 95 % confidence interval (CI) 0.84-1.11] and >= 75 % repigmentation (RR = 0.96, 95 % CI 0.71-1.30). Likewise, no study found significant differences between excimer lamps and NB-UVB (RR = 1.14, 95 % CI 0.88-1.48 for >= 50 % repigmentation; RR = 1.81, 95 % CI 0.11-29.52 for >= 75 % repigmentation). Adverse effects were mild, including pruritus, burning sensation, and dryness, none of which interrupted treatment. Conclusions To our knowledge, this is the first systematic review of the efficacy and safety of excimer lamp treatment for vitiligo. Excimer lamps, excimer laser, and NB-UVB are all safe and effective in repigmentation of vitiligo lesions. Safety, effectiveness, and cost are considerations when choosing treatment.
publishDate 2016
dc.date.none.fl_str_mv 2016
2020-11-03T14:40:36Z
2020-11-03T14:40:36Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv https://doi.org/10.1007/s40257-015-0164-2
American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016.
10.1007/s40257-015-0164-2
1175-0561
https://repositorio.unifesp.br/handle/11600/58635
WOS:000368988100003
url https://doi.org/10.1007/s40257-015-0164-2
https://repositorio.unifesp.br/handle/11600/58635
identifier_str_mv American Journal Of Clinical Dermatology. Northcote, v. 17, n. 1, p. 23-32, 2016.
10.1007/s40257-015-0164-2
1175-0561
WOS:000368988100003
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv American Journal Of Clinical Dermatology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 23-32
dc.coverage.none.fl_str_mv Northcote
dc.publisher.none.fl_str_mv Adis Int Ltd
publisher.none.fl_str_mv Adis Int Ltd
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
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