Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil
Autor(a) principal: | |
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Data de Publicação: | 2006 |
Outros Autores: | , , , , , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/3045 http://dx.doi.org/10.1590/S0100-879X2006000400012 |
Resumo: | Epidemiological data regarding tetanus and diphtheria immunity in elderly people in Brazil are scarce. During the First National Immunization Campaign for the Elderly in Brazil in April 1999, 98 individuals (median age: 84 years) received one tetanus-dyphtheria (Td) vaccine dose (Butantan Institute, lot number 9808079/G). Inclusion criteria were elderly individuals without a history of severe immunosuppressive disease, acute infectious disease or use of immunomodulators. Blood samples were collected immediately before the vaccine and 30 days later. Serum was separated and stored at -20ºC until analysis. Tetanus and diphtheria antibodies were measured by the double-antigen ELISA test. Tetanus and diphtheria antibody concentrations lower than 0.01 IU/mL were considered to indicate the absence of protection, between 0.01 and 0.09 IU/mL were considered to indicate basic immunity, and values of 0.1 IU/mL or higher were considered to indicate full protection. Before vaccination, 18% of the individuals were susceptible to diphtheria and 94% were susceptible to tetanus. After one Td dose, 78% became fully immune to diphtheria, 13% attained basic immunity, and 9% were still susceptible to the disease. In contrast, 79% remained susceptible to tetanus, 4% had basic immunity and 17% were fully immune. Although one Td dose increases immunity to diphtheria in many elderly people who live in Brazil, a complete vaccination series appears to be necessary for the prevention of tetanus. |
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Weckx, Lily Yin [UNIFESP]Divino-Goes, K. [UNIFESP]Lihama, D.m. [UNIFESP]Carraro, Emerson [UNIFESP]Bellei, Nancy Cristina Junqueira [UNIFESP]Granato, Celso Francisco Hernandes [UNIFESP]De Moraes-Pinto, Maria Isabel [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:32:05Z2015-06-14T13:32:05Z2006-04-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 519-523, 2006.0100-879Xhttp://repositorio.unifesp.br/handle/11600/3045http://dx.doi.org/10.1590/S0100-879X2006000400012S0100-879X2006000400012.pdfS0100-879X200600040001210.1590/S0100-879X2006000400012WOS:000237049700012Epidemiological data regarding tetanus and diphtheria immunity in elderly people in Brazil are scarce. During the First National Immunization Campaign for the Elderly in Brazil in April 1999, 98 individuals (median age: 84 years) received one tetanus-dyphtheria (Td) vaccine dose (Butantan Institute, lot number 9808079/G). Inclusion criteria were elderly individuals without a history of severe immunosuppressive disease, acute infectious disease or use of immunomodulators. Blood samples were collected immediately before the vaccine and 30 days later. Serum was separated and stored at -20ºC until analysis. Tetanus and diphtheria antibodies were measured by the double-antigen ELISA test. Tetanus and diphtheria antibody concentrations lower than 0.01 IU/mL were considered to indicate the absence of protection, between 0.01 and 0.09 IU/mL were considered to indicate basic immunity, and values of 0.1 IU/mL or higher were considered to indicate full protection. Before vaccination, 18% of the individuals were susceptible to diphtheria and 94% were susceptible to tetanus. After one Td dose, 78% became fully immune to diphtheria, 13% attained basic immunity, and 9% were still susceptible to the disease. In contrast, 79% remained susceptible to tetanus, 4% had basic immunity and 17% were fully immune. Although one Td dose increases immunity to diphtheria in many elderly people who live in Brazil, a complete vaccination series appears to be necessary for the prevention of tetanus.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de Infectologia PediátricaUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Disciplina de InfectologiaUNIFESP, EPM, Disciplina de Infectologia PediátricaUNIFESP, EPM, Disciplina de InfectologiaSciELO519-523engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchElderlyTetanusDiphtheriaImmunizationEffect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2006000400012.pdfapplication/pdf453863${dspace.ui.url}/bitstream/11600/3045/1/S0100-879X2006000400012.pdfecf5fdc457e1f67fb81349c02c25c314MD51open accessTEXTS0100-879X2006000400012.pdf.txtS0100-879X2006000400012.pdf.txtExtracted texttext/plain17243${dspace.ui.url}/bitstream/11600/3045/21/S0100-879X2006000400012.pdf.txtc9650bbe57eec15d3b455a00f091332fMD521open accessTHUMBNAILS0100-879X2006000400012.pdf.jpgS0100-879X2006000400012.pdf.jpgIM Thumbnailimage/jpeg5086${dspace.ui.url}/bitstream/11600/3045/23/S0100-879X2006000400012.pdf.jpg3f62096d6ea3f5526424e8d595f37100MD523open access11600/30452023-06-05 19:21:05.293open accessoai:repositorio.unifesp.br:11600/3045Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:21:05Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
title |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
spellingShingle |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil Weckx, Lily Yin [UNIFESP] Elderly Tetanus Diphtheria Immunization |
title_short |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
title_full |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
title_fullStr |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
title_full_unstemmed |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
title_sort |
Effect of a single tetanus-diphtheria vaccine dose on the immunity of elderly people in São Paulo, Brazil |
author |
Weckx, Lily Yin [UNIFESP] |
author_facet |
Weckx, Lily Yin [UNIFESP] Divino-Goes, K. [UNIFESP] Lihama, D.m. [UNIFESP] Carraro, Emerson [UNIFESP] Bellei, Nancy Cristina Junqueira [UNIFESP] Granato, Celso Francisco Hernandes [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
author_role |
author |
author2 |
Divino-Goes, K. [UNIFESP] Lihama, D.m. [UNIFESP] Carraro, Emerson [UNIFESP] Bellei, Nancy Cristina Junqueira [UNIFESP] Granato, Celso Francisco Hernandes [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
author2_role |
author author author author author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Weckx, Lily Yin [UNIFESP] Divino-Goes, K. [UNIFESP] Lihama, D.m. [UNIFESP] Carraro, Emerson [UNIFESP] Bellei, Nancy Cristina Junqueira [UNIFESP] Granato, Celso Francisco Hernandes [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
dc.subject.eng.fl_str_mv |
Elderly Tetanus Diphtheria Immunization |
topic |
Elderly Tetanus Diphtheria Immunization |
description |
Epidemiological data regarding tetanus and diphtheria immunity in elderly people in Brazil are scarce. During the First National Immunization Campaign for the Elderly in Brazil in April 1999, 98 individuals (median age: 84 years) received one tetanus-dyphtheria (Td) vaccine dose (Butantan Institute, lot number 9808079/G). Inclusion criteria were elderly individuals without a history of severe immunosuppressive disease, acute infectious disease or use of immunomodulators. Blood samples were collected immediately before the vaccine and 30 days later. Serum was separated and stored at -20ºC until analysis. Tetanus and diphtheria antibodies were measured by the double-antigen ELISA test. Tetanus and diphtheria antibody concentrations lower than 0.01 IU/mL were considered to indicate the absence of protection, between 0.01 and 0.09 IU/mL were considered to indicate basic immunity, and values of 0.1 IU/mL or higher were considered to indicate full protection. Before vaccination, 18% of the individuals were susceptible to diphtheria and 94% were susceptible to tetanus. After one Td dose, 78% became fully immune to diphtheria, 13% attained basic immunity, and 9% were still susceptible to the disease. In contrast, 79% remained susceptible to tetanus, 4% had basic immunity and 17% were fully immune. Although one Td dose increases immunity to diphtheria in many elderly people who live in Brazil, a complete vaccination series appears to be necessary for the prevention of tetanus. |
publishDate |
2006 |
dc.date.issued.fl_str_mv |
2006-04-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:32:05Z |
dc.date.available.fl_str_mv |
2015-06-14T13:32:05Z |
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info:eu-repo/semantics/publishedVersion |
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info:eu-repo/semantics/article |
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article |
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dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 519-523, 2006. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3045 http://dx.doi.org/10.1590/S0100-879X2006000400012 |
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0100-879X |
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S0100-879X2006000400012.pdf |
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S0100-879X2006000400012 |
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10.1590/S0100-879X2006000400012 |
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WOS:000237049700012 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 39, n. 4, p. 519-523, 2006. 0100-879X S0100-879X2006000400012.pdf S0100-879X2006000400012 10.1590/S0100-879X2006000400012 WOS:000237049700012 |
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http://repositorio.unifesp.br/handle/11600/3045 http://dx.doi.org/10.1590/S0100-879X2006000400012 |
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