Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil
Autor(a) principal: | |
---|---|
Data de Publicação: | 2007 |
Outros Autores: | , |
Tipo de documento: | Artigo |
Idioma: | eng |
Título da fonte: | Repositório Institucional da UNIFESP |
Texto Completo: | http://repositorio.unifesp.br/handle/11600/3509 http://dx.doi.org/10.1590/S0100-879X2006005000071 |
Resumo: | Tetanus and diphtheria vaccines are of special concern in adolescents because boosters are necessary for adequate maintenance of protection and are often omitted. We assessed serum levels of tetanus and diphtheria antibodies in adolescents and their association with vaccination status. From May to October 2001, we evaluated the vaccination records of 208 adolescents aged 10 to 20 years in São Paulo, Brazil. Antibodies to tetanus and diphtheria were detected using double-antigen ELISA and vaccination records were analyzed according to the guidelines of the Brazilian National Immunization Program. All adolescents had received complete primary vaccinations against tetanus and diphtheria, but 23.1% of them had not received a booster dose in the last 10 years. All adolescents were immune to tetanus and 88.9% were fully protected (antibodies ³0.1 IU/mL). One individual (0.5%) was non-immune to diphtheria and 86% were fully protected against the disease. Adolescents with up-to-date vaccination records had higher antibody levels than those with not up-to-date records for tetanus (0.763 vs 0.239 IU/mL, t-test: P < 0.0001) and diphtheria (0.366 vs 0.233 IU/mL, t-test: P = 0.014). Full immunity against tetanus (antibodies ³0.1 IU/mL) was higher among individuals with up-to-date vaccination (93.1%) when compared to those with not up-to-date records (75%, Fisher's exact test: P = 0.001). All adolescents had received basic immunization in childhood and were protected against tetanus and diphtheria. However, these data indicate that more emphasis should be placed on the tetanus-diphtheria booster in order to avoid a decay in antibody levels. |
id |
UFSP_d917d5d9ff5fac99394ab5ad2086a9fb |
---|---|
oai_identifier_str |
oai:repositorio.unifesp.br:11600/3509 |
network_acronym_str |
UFSP |
network_name_str |
Repositório Institucional da UNIFESP |
repository_id_str |
3465 |
spelling |
Dinelli, Maria Isabel Saraiva [UNIFESP]Fisberg, Mauro [UNIFESP]De Moraes-Pinto, Maria Isabel [UNIFESP]Universidade Federal de São Paulo (UNIFESP)2015-06-14T13:36:41Z2015-06-14T13:36:41Z2007-02-01Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 259-263, 2007.0100-879Xhttp://repositorio.unifesp.br/handle/11600/3509http://dx.doi.org/10.1590/S0100-879X2006005000071S0100-879X2007000200013.pdfS0100-879X200700020001310.1590/S0100-879X2006005000071WOS:000243977400013Tetanus and diphtheria vaccines are of special concern in adolescents because boosters are necessary for adequate maintenance of protection and are often omitted. We assessed serum levels of tetanus and diphtheria antibodies in adolescents and their association with vaccination status. From May to October 2001, we evaluated the vaccination records of 208 adolescents aged 10 to 20 years in São Paulo, Brazil. Antibodies to tetanus and diphtheria were detected using double-antigen ELISA and vaccination records were analyzed according to the guidelines of the Brazilian National Immunization Program. All adolescents had received complete primary vaccinations against tetanus and diphtheria, but 23.1% of them had not received a booster dose in the last 10 years. All adolescents were immune to tetanus and 88.9% were fully protected (antibodies ³0.1 IU/mL). One individual (0.5%) was non-immune to diphtheria and 86% were fully protected against the disease. Adolescents with up-to-date vaccination records had higher antibody levels than those with not up-to-date records for tetanus (0.763 vs 0.239 IU/mL, t-test: P < 0.0001) and diphtheria (0.366 vs 0.233 IU/mL, t-test: P = 0.014). Full immunity against tetanus (antibodies ³0.1 IU/mL) was higher among individuals with up-to-date vaccination (93.1%) when compared to those with not up-to-date records (75%, Fisher's exact test: P = 0.001). All adolescents had received basic immunization in childhood and were protected against tetanus and diphtheria. However, these data indicate that more emphasis should be placed on the tetanus-diphtheria booster in order to avoid a decay in antibody levels.Universidade Federal de São Paulo (UNIFESP) Departamento de PediatriaUniversidade Federal de São Paulo (UNIFESP) Departamento de Pediatria Centro de Atendimento e Apoio ao AdolescenteUNIFESP, Depto. de PediatriaUNIFESP, Depto. de Pediatria Centro de Atendimento e Apoio ao AdolescenteSciELO259-263engAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological ResearchVaccineTetanusDiphtheriaAdolescentsAntitoxinsImmunizationTetanus and diphtheria immunity in adolescents from São Paulo, Brazilinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALS0100-879X2007000200013.pdfapplication/pdf533747${dspace.ui.url}/bitstream/11600/3509/1/S0100-879X2007000200013.pdfa97046a7b178250c997e5e4038aeaae8MD51open accessTEXTS0100-879X2007000200013.pdf.txtS0100-879X2007000200013.pdf.txtExtracted texttext/plain18182${dspace.ui.url}/bitstream/11600/3509/21/S0100-879X2007000200013.pdf.txt3cbaac1eadd23c8f7bfcba07345b2581MD521open accessTHUMBNAILS0100-879X2007000200013.pdf.jpgS0100-879X2007000200013.pdf.jpgIM Thumbnailimage/jpeg5591${dspace.ui.url}/bitstream/11600/3509/23/S0100-879X2007000200013.pdf.jpg36fbbbdfef22337ede5d7db826b8e59bMD523open access11600/35092023-06-05 19:31:58.606open accessoai:repositorio.unifesp.br:11600/3509Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652023-06-05T22:31:58Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false |
dc.title.en.fl_str_mv |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
title |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
spellingShingle |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil Dinelli, Maria Isabel Saraiva [UNIFESP] Vaccine Tetanus Diphtheria Adolescents Antitoxins Immunization |
title_short |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
title_full |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
title_fullStr |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
title_full_unstemmed |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
title_sort |
Tetanus and diphtheria immunity in adolescents from São Paulo, Brazil |
author |
Dinelli, Maria Isabel Saraiva [UNIFESP] |
author_facet |
Dinelli, Maria Isabel Saraiva [UNIFESP] Fisberg, Mauro [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
author_role |
author |
author2 |
Fisberg, Mauro [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
author2_role |
author author |
dc.contributor.institution.none.fl_str_mv |
Universidade Federal de São Paulo (UNIFESP) |
dc.contributor.author.fl_str_mv |
Dinelli, Maria Isabel Saraiva [UNIFESP] Fisberg, Mauro [UNIFESP] De Moraes-Pinto, Maria Isabel [UNIFESP] |
dc.subject.eng.fl_str_mv |
Vaccine Tetanus Diphtheria Adolescents Antitoxins Immunization |
topic |
Vaccine Tetanus Diphtheria Adolescents Antitoxins Immunization |
description |
Tetanus and diphtheria vaccines are of special concern in adolescents because boosters are necessary for adequate maintenance of protection and are often omitted. We assessed serum levels of tetanus and diphtheria antibodies in adolescents and their association with vaccination status. From May to October 2001, we evaluated the vaccination records of 208 adolescents aged 10 to 20 years in São Paulo, Brazil. Antibodies to tetanus and diphtheria were detected using double-antigen ELISA and vaccination records were analyzed according to the guidelines of the Brazilian National Immunization Program. All adolescents had received complete primary vaccinations against tetanus and diphtheria, but 23.1% of them had not received a booster dose in the last 10 years. All adolescents were immune to tetanus and 88.9% were fully protected (antibodies ³0.1 IU/mL). One individual (0.5%) was non-immune to diphtheria and 86% were fully protected against the disease. Adolescents with up-to-date vaccination records had higher antibody levels than those with not up-to-date records for tetanus (0.763 vs 0.239 IU/mL, t-test: P < 0.0001) and diphtheria (0.366 vs 0.233 IU/mL, t-test: P = 0.014). Full immunity against tetanus (antibodies ³0.1 IU/mL) was higher among individuals with up-to-date vaccination (93.1%) when compared to those with not up-to-date records (75%, Fisher's exact test: P = 0.001). All adolescents had received basic immunization in childhood and were protected against tetanus and diphtheria. However, these data indicate that more emphasis should be placed on the tetanus-diphtheria booster in order to avoid a decay in antibody levels. |
publishDate |
2007 |
dc.date.issued.fl_str_mv |
2007-02-01 |
dc.date.accessioned.fl_str_mv |
2015-06-14T13:36:41Z |
dc.date.available.fl_str_mv |
2015-06-14T13:36:41Z |
dc.type.status.fl_str_mv |
info:eu-repo/semantics/publishedVersion |
dc.type.driver.fl_str_mv |
info:eu-repo/semantics/article |
format |
article |
status_str |
publishedVersion |
dc.identifier.citation.fl_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 259-263, 2007. |
dc.identifier.uri.fl_str_mv |
http://repositorio.unifesp.br/handle/11600/3509 http://dx.doi.org/10.1590/S0100-879X2006005000071 |
dc.identifier.issn.none.fl_str_mv |
0100-879X |
dc.identifier.file.none.fl_str_mv |
S0100-879X2007000200013.pdf |
dc.identifier.scielo.none.fl_str_mv |
S0100-879X2007000200013 |
dc.identifier.doi.none.fl_str_mv |
10.1590/S0100-879X2006005000071 |
dc.identifier.wos.none.fl_str_mv |
WOS:000243977400013 |
identifier_str_mv |
Brazilian Journal of Medical and Biological Research. Associação Brasileira de Divulgação Científica, v. 40, n. 2, p. 259-263, 2007. 0100-879X S0100-879X2007000200013.pdf S0100-879X2007000200013 10.1590/S0100-879X2006005000071 WOS:000243977400013 |
url |
http://repositorio.unifesp.br/handle/11600/3509 http://dx.doi.org/10.1590/S0100-879X2006005000071 |
dc.language.iso.fl_str_mv |
eng |
language |
eng |
dc.relation.ispartof.none.fl_str_mv |
Brazilian Journal of Medical and Biological Research |
dc.rights.driver.fl_str_mv |
info:eu-repo/semantics/openAccess |
eu_rights_str_mv |
openAccess |
dc.format.none.fl_str_mv |
259-263 |
dc.publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
publisher.none.fl_str_mv |
Associação Brasileira de Divulgação Científica |
dc.source.none.fl_str_mv |
reponame:Repositório Institucional da UNIFESP instname:Universidade Federal de São Paulo (UNIFESP) instacron:UNIFESP |
instname_str |
Universidade Federal de São Paulo (UNIFESP) |
instacron_str |
UNIFESP |
institution |
UNIFESP |
reponame_str |
Repositório Institucional da UNIFESP |
collection |
Repositório Institucional da UNIFESP |
bitstream.url.fl_str_mv |
${dspace.ui.url}/bitstream/11600/3509/1/S0100-879X2007000200013.pdf ${dspace.ui.url}/bitstream/11600/3509/21/S0100-879X2007000200013.pdf.txt ${dspace.ui.url}/bitstream/11600/3509/23/S0100-879X2007000200013.pdf.jpg |
bitstream.checksum.fl_str_mv |
a97046a7b178250c997e5e4038aeaae8 3cbaac1eadd23c8f7bfcba07345b2581 36fbbbdfef22337ede5d7db826b8e59b |
bitstream.checksumAlgorithm.fl_str_mv |
MD5 MD5 MD5 |
repository.name.fl_str_mv |
Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP) |
repository.mail.fl_str_mv |
|
_version_ |
1783460298847420416 |