Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs

Detalhes bibliográficos
Autor(a) principal: Angelieri, F.
Data de Publicação: 2010
Outros Autores: Carlin, Viviane [UNIFESP], Saez, D. M., Pozzi, Renan [UNIFESP], Ribeiro, Daniel Araki [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: http://dx.doi.org/10.1259/dmfr/24791952
http://repositorio.unifesp.br/handle/11600/32929
Resumo: Objectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography.Methods: Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days.Results: the results revealed no statistically significant difference (P > 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis.Conclusions: Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 437-440. doi: 10.1259/dmfr/24791952
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spelling Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographsbuccal mucosa cellsradiographic documentationmicronucleus testObjectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography.Methods: Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days.Results: the results revealed no statistically significant difference (P > 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis.Conclusions: Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 437-440. doi: 10.1259/dmfr/24791952Universidade Federal de São Paulo, Dept Biosci, UNIFESP, São Paulo, BrazilSão Paulo Methodist Univ, Dept Orthodont, UMESP, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, Paulista Med Sch, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Biosci, UNIFESP, São Paulo, BrazilUniversidade Federal de São Paulo, Dept Pathol, Paulista Med Sch, São Paulo, BrazilWeb of ScienceFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)FAPESP: 07/01228-4British Inst RadiologyUniversidade Federal de São Paulo (UNIFESP)São Paulo Methodist UnivAngelieri, F.Carlin, Viviane [UNIFESP]Saez, D. M.Pozzi, Renan [UNIFESP]Ribeiro, Daniel Araki [UNIFESP]2016-01-24T14:05:29Z2016-01-24T14:05:29Z2010-10-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersion437-440http://dx.doi.org/10.1259/dmfr/24791952Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 7, p. 437-440, 2010.10.1259/dmfr/247919520250-832Xhttp://repositorio.unifesp.br/handle/11600/32929WOS:000281761200007engDentomaxillofacial Radiologyinfo:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESP2024-10-10T13:38:34Zoai:repositorio.unifesp.br/:11600/32929Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestbiblioteca.csp@unifesp.bropendoar:34652024-10-10T13:38:34Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.none.fl_str_mv Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
title Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
spellingShingle Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
Angelieri, F.
buccal mucosa cells
radiographic documentation
micronucleus test
title_short Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
title_full Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
title_fullStr Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
title_full_unstemmed Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
title_sort Mutagenicity and cytotoxicity assessment in patients undergoing orthodontic radiographs
author Angelieri, F.
author_facet Angelieri, F.
Carlin, Viviane [UNIFESP]
Saez, D. M.
Pozzi, Renan [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
author_role author
author2 Carlin, Viviane [UNIFESP]
Saez, D. M.
Pozzi, Renan [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
author2_role author
author
author
author
dc.contributor.none.fl_str_mv Universidade Federal de São Paulo (UNIFESP)
São Paulo Methodist Univ
dc.contributor.author.fl_str_mv Angelieri, F.
Carlin, Viviane [UNIFESP]
Saez, D. M.
Pozzi, Renan [UNIFESP]
Ribeiro, Daniel Araki [UNIFESP]
dc.subject.por.fl_str_mv buccal mucosa cells
radiographic documentation
micronucleus test
topic buccal mucosa cells
radiographic documentation
micronucleus test
description Objectives: the aim of the present study was to evaluate DNA damage (micronucleus) and cellular death (pyknosis, karyolysis and karyorrhexis) in exfoliated buccal mucosa cells from individuals following radiography.Methods: Lateral and frontal cephalometric X-ray and panoramic dental X-rays were taken of a total of 18 healthy patients (6 male and 12 female) referred for orthodontic therapy. Exfoliated oral mucosa cells were collected immediately before X-ray exposure and after 10 days.Results: the results revealed no statistically significant difference (P > 0.05) in the frequency micronucleated oral mucosa cells after X-ray exposure. However, X-ray was able to increase other nuclear alterations closely related to cytotoxicity, such as karyorrhexis, pyknosis and karyolysis.Conclusions: Data indicated that exposure to certain radiography may not be a factor in inducing chromosomal damage, but it does promote cytotoxicity. Dentomaxillofacial Radiology (2010) 39, 437-440. doi: 10.1259/dmfr/24791952
publishDate 2010
dc.date.none.fl_str_mv 2010-10-01
2016-01-24T14:05:29Z
2016-01-24T14:05:29Z
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
format article
status_str publishedVersion
dc.identifier.uri.fl_str_mv http://dx.doi.org/10.1259/dmfr/24791952
Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 7, p. 437-440, 2010.
10.1259/dmfr/24791952
0250-832X
http://repositorio.unifesp.br/handle/11600/32929
WOS:000281761200007
url http://dx.doi.org/10.1259/dmfr/24791952
http://repositorio.unifesp.br/handle/11600/32929
identifier_str_mv Dentomaxillofacial Radiology. London: British Inst Radiology, v. 39, n. 7, p. 437-440, 2010.
10.1259/dmfr/24791952
0250-832X
WOS:000281761200007
dc.language.iso.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv Dentomaxillofacial Radiology
dc.rights.driver.fl_str_mv info:eu-repo/semantics/openAccess
eu_rights_str_mv openAccess
dc.format.none.fl_str_mv 437-440
dc.publisher.none.fl_str_mv British Inst Radiology
publisher.none.fl_str_mv British Inst Radiology
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
instacron_str UNIFESP
institution UNIFESP
reponame_str Repositório Institucional da UNIFESP
collection Repositório Institucional da UNIFESP
repository.name.fl_str_mv Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)
repository.mail.fl_str_mv biblioteca.csp@unifesp.br
_version_ 1814268450590162944

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