Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates

Detalhes bibliográficos
Autor(a) principal: Travassos, Luiz R. [UNIFESP]
Data de Publicação: 2017
Outros Autores: Taborda, Carlos P. [UNIFESP]
Tipo de documento: Artigo
Idioma: eng
Título da fonte: Repositório Institucional da UNIFESP
Texto Completo: https://repositorio.unifesp.br/handle/11600/54931
http://dx.doi.org/10.3389/fimmu.2017.00224
Resumo: Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America
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spelling Travassos, Luiz R. [UNIFESP]Taborda, Carlos P. [UNIFESP]2020-07-17T14:02:39Z2020-07-17T14:02:39Z2017Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.1664-3224https://repositorio.unifesp.br/handle/11600/54931http://dx.doi.org/10.3389/fimmu.2017.00224WOS000395863200001.pdf10.3389/fimmu.2017.00224WOS:000395863200001Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South AmericaHistoplasma capsulatum, Coccidioides posadasii, and Coccidioides immitis, and the Sporothrix spp. complex are other important pathogens. Associated with dimorphic fungi other important infections are caused by yeast such as Candida spp. and Cryptococcus spp. or mold such as Aspergillus spp., which are also fungal agents of deadly infections. Nowadays, the actual tendency of therapy is the development of a pan-fungal vaccine. This is, however, not easy because of the complexity of eukaryotic cells and the particularities of different species and isolates. Albeit there are several experimental vaccines being studied, we will focus mainly on peptide vaccines or epitopes of T-cell receptors inducing protective fungal responses. These peptides can be carried by antibody inducing beta-( 1,3)-glucan oligo or polysaccharides, or be mixed with them for administration. The present review discusses the efficacy of linear peptide epitopes in the context of antifungal immunization and vaccine proposition.FAPESPCAPESUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilUniv Fed Sao Paulo, Dept Microbiol Immunol & Parasitol, Sao Paulo, BrazilUniv Fed Sao Paulo, Inst Biomed Sci, Dept Microbiol, Sao Paulo, BrazilUniv Fed Sao Paulo, Lab Med Mycol IMTSP HCFMUSP LIM53, Sao Paulo, BrazilFAPESP: 2016/08730-6FAPESP: 2010/51423-0Web of Science-engFrontiers Media SaFrontiers In ImmunologypeptidevaccineantibodyfungiParacoccidioidesLinear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidatesinfo:eu-repo/semantics/publishedVersioninfo:eu-repo/semantics/articleLausanne8info:eu-repo/semantics/openAccessreponame:Repositório Institucional da UNIFESPinstname:Universidade Federal de São Paulo (UNIFESP)instacron:UNIFESPORIGINALWOS000395863200001.pdfapplication/pdf724433${dspace.ui.url}/bitstream/11600/54931/1/WOS000395863200001.pdffdc8dd891e55eb6552b956f0f2becfe0MD51open accessTEXTWOS000395863200001.pdf.txtWOS000395863200001.pdf.txtExtracted texttext/plain66725${dspace.ui.url}/bitstream/11600/54931/2/WOS000395863200001.pdf.txt10e7ea76cae74d941899d4a83f4a97edMD52open accessTHUMBNAILWOS000395863200001.pdf.jpgWOS000395863200001.pdf.jpgIM Thumbnailimage/jpeg6690${dspace.ui.url}/bitstream/11600/54931/4/WOS000395863200001.pdf.jpga9a598be306075c7b44fc6f4bcad007aMD54open access11600/549312022-08-01 05:24:04.813open accessoai:repositorio.unifesp.br:11600/54931Repositório InstitucionalPUBhttp://www.repositorio.unifesp.br/oai/requestopendoar:34652022-08-01T08:24:04Repositório Institucional da UNIFESP - Universidade Federal de São Paulo (UNIFESP)false
dc.title.en.fl_str_mv Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
spellingShingle Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
Travassos, Luiz R. [UNIFESP]
peptide
vaccine
antibody
fungi
Paracoccidioides
title_short Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_full Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_fullStr Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_full_unstemmed Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
title_sort Linear epitopes of Paracoccidioides brasiliensis and Other Fungal Agents of Human Systemic Mycoses As vaccine Candidates
author Travassos, Luiz R. [UNIFESP]
author_facet Travassos, Luiz R. [UNIFESP]
Taborda, Carlos P. [UNIFESP]
author_role author
author2 Taborda, Carlos P. [UNIFESP]
author2_role author
dc.contributor.author.fl_str_mv Travassos, Luiz R. [UNIFESP]
Taborda, Carlos P. [UNIFESP]
dc.subject.eng.fl_str_mv peptide
vaccine
antibody
fungi
Paracoccidioides
topic peptide
vaccine
antibody
fungi
Paracoccidioides
description Dimorphic fungi are agents of systemic mycoses associated with significant morbidity and frequent lethality in the Americas. Among the pathogenic species are Paracoccidioides brasiliensis and Paracoccidioides lutzii, which predominate in South America
publishDate 2017
dc.date.issued.fl_str_mv 2017
dc.date.accessioned.fl_str_mv 2020-07-17T14:02:39Z
dc.date.available.fl_str_mv 2020-07-17T14:02:39Z
dc.type.status.fl_str_mv info:eu-repo/semantics/publishedVersion
dc.type.driver.fl_str_mv info:eu-repo/semantics/article
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dc.identifier.citation.fl_str_mv Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.
dc.identifier.uri.fl_str_mv https://repositorio.unifesp.br/handle/11600/54931
http://dx.doi.org/10.3389/fimmu.2017.00224
dc.identifier.issn.none.fl_str_mv 1664-3224
dc.identifier.file.none.fl_str_mv WOS000395863200001.pdf
dc.identifier.doi.none.fl_str_mv 10.3389/fimmu.2017.00224
dc.identifier.wos.none.fl_str_mv WOS:000395863200001
identifier_str_mv Frontiers In Immunology. Lausanne, v. 8, p. -, 2017.
1664-3224
WOS000395863200001.pdf
10.3389/fimmu.2017.00224
WOS:000395863200001
url https://repositorio.unifesp.br/handle/11600/54931
http://dx.doi.org/10.3389/fimmu.2017.00224
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dc.publisher.none.fl_str_mv Frontiers Media Sa
publisher.none.fl_str_mv Frontiers Media Sa
dc.source.none.fl_str_mv reponame:Repositório Institucional da UNIFESP
instname:Universidade Federal de São Paulo (UNIFESP)
instacron:UNIFESP
instname_str Universidade Federal de São Paulo (UNIFESP)
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reponame_str Repositório Institucional da UNIFESP
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